DPYD and LXN

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		DPYD	LXN
Gene Name		dihydropyrimidine dehydrogenase	latexin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol	Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Dihydroorotate Dehydrogenase Activity Dihydropyrimidine Dehydrogenase (NADP+) Activity Protein Homodimerization Activity Metal Ion Binding Flavin Adenine Dinucleotide Binding NADP Binding 4 Iron, 4 Sulfur Cluster Binding	Metalloendopeptidase Inhibitor Activity Heparin Binding
	Biological Process	Purine Nucleobase Catabolic Process Pyrimidine Nucleobase Metabolic Process Pyrimidine Nucleobase Catabolic Process Thymine Catabolic Process Uracil Catabolic Process Thymidine Catabolic Process UMP Biosynthetic Process Beta-alanine Biosynthetic Process Small Molecule Metabolic Process Pyrimidine Nucleoside Catabolic Process Nucleobase-containing Small Molecule Metabolic Process Oxidation-reduction Process	Inflammatory Response Negative Regulation Of Endopeptidase Activity Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain
Pathways		Pyrimidine catabolism Pyrimidine metabolism Metabolism of nucleotides
Drugs		(5s)-5-Iododihydro-2,4(1h,3h)-Pyrimidinedione Nadph Dihydro-Nicotinamide-Adenine-Dinucleotidephosphate 6-Carboxymethyluracil Flavin-Adenine Dinucleotide Riboflavin Monophosphate Uracil 5-Iodouracil
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Platelet counts ( 21507922) Schizophrenia ( 22688191)
Protein-Protein Interactions		2 interactors: GOPC LXN	6 interactors: DPYD GSG1L MAGEA8 TMEM14A TRIM39 ZKSCAN4
Entrez ID		1806	56925
HPRD ID		02036	14327
Ensembl ID		ENSG00000188641	ENSG00000079257
Uniprot IDs		Q12882	Q9BS40
PDB IDs			2BO9
Enriched GO Terms of Interacting Partners?		Cytoplasmic Sequestering Of CFTR Protein Negative Regulation Of Golgi To Plasma Membrane Protein Transport Regulation Of Golgi To Plasma Membrane Protein Transport Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Apical Protein Localization Negative Regulation Of Protein Localization To Plasma Membrane Cytoplasmic Sequestering Of Protein Asymmetric Protein Localization Detection Of Temperature Stimulus Spermatid Nucleus Differentiation Sensory Perception Of Temperature Stimulus Golgi To Plasma Membrane Transport Regulation Of Establishment Of Protein Localization To Plasma Membrane Regulation Of Protein Localization To Plasma Membrane Post-Golgi Vesicle-mediated Transport Negative Regulation Of Intracellular Protein Transport Sensory Perception Of Pain ER To Golgi Vesicle-mediated Transport Negative Regulation Of Intracellular Transport Nucleus Organization Regulation Of Catalytic Activity Spermatid Development Maintenance Of Protein Location In Cell Spermatid Differentiation Maintenance Of Protein Location Maintenance Of Location In Cell	Thymidine Catabolic Process Beta-alanine Biosynthetic Process Uracil Catabolic Process Deoxyribonucleoside Catabolic Process Beta-alanine Metabolic Process Uracil Metabolic Process Thymine Metabolic Process Thymine Catabolic Process Thymidine Metabolic Process Purine Nucleobase Catabolic Process Pyrimidine Nucleobase Catabolic Process Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process UMP Biosynthetic Process Pyrimidine Nucleoside Catabolic Process Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Pyrimidine Nucleobase Metabolic Process Purine Nucleobase Metabolic Process Pyrimidine Ribonucleotide Biosynthetic Process
Tagcloud ?		advance cdc25a cohorts dach1 demonstrating doi endocrine exerting former functionally fyn gbp1 itpr1 june lyn mcf onc oncogene online overcome parental prkca prlr publication restored s0 subcellular tamoxifen tamr
Tagcloud (Difference) ?		advance cdc25a cohorts dach1 demonstrating doi endocrine exerting former functionally fyn gbp1 itpr1 june lyn mcf onc oncogene online overcome parental prkca prlr publication restored s0 subcellular tamoxifen tamr
Tagcloud (Intersection) ?