DPYD

Gene Name		dihydropyrimidine dehydrogenase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol
	Molecular Function	Dihydroorotate Dehydrogenase Activity Dihydropyrimidine Dehydrogenase (NADP+) Activity Protein Homodimerization Activity Metal Ion Binding Flavin Adenine Dinucleotide Binding NADP Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Purine Nucleobase Catabolic Process Pyrimidine Nucleobase Metabolic Process Pyrimidine Nucleobase Catabolic Process Thymine Catabolic Process Uracil Catabolic Process Thymidine Catabolic Process UMP Biosynthetic Process Beta-alanine Biosynthetic Process Small Molecule Metabolic Process Pyrimidine Nucleoside Catabolic Process Nucleobase-containing Small Molecule Metabolic Process Oxidation-reduction Process
Pathways		Pyrimidine catabolism Pyrimidine metabolism Metabolism of nucleotides
Drugs		(5s)-5-Iododihydro-2,4(1h,3h)-Pyrimidinedione Nadph Dihydro-Nicotinamide-Adenine-Dinucleotidephosphate 6-Carboxymethyluracil Flavin-Adenine Dinucleotide Riboflavin Monophosphate Uracil 5-Iodouracil
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Platelet counts ( 21507922) Schizophrenia ( 22688191)
Protein-protein Interactions		2 interactors: GOPC LXN
Entrez ID		1806
HPRD ID		02036
Ensembl ID		ENSG00000188641
Uniprot IDs		Q12882
PDB IDs
Enriched GO Terms of Interacting Partners?		Cytoplasmic Sequestering Of CFTR Protein Negative Regulation Of Golgi To Plasma Membrane Protein Transport Regulation Of Golgi To Plasma Membrane Protein Transport Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Apical Protein Localization Negative Regulation Of Protein Localization To Plasma Membrane Cytoplasmic Sequestering Of Protein Asymmetric Protein Localization Detection Of Temperature Stimulus Spermatid Nucleus Differentiation Sensory Perception Of Temperature Stimulus Golgi To Plasma Membrane Transport Regulation Of Establishment Of Protein Localization To Plasma Membrane Regulation Of Protein Localization To Plasma Membrane Post-Golgi Vesicle-mediated Transport Negative Regulation Of Intracellular Protein Transport Sensory Perception Of Pain ER To Golgi Vesicle-mediated Transport Negative Regulation Of Intracellular Transport Nucleus Organization Regulation Of Catalytic Activity Spermatid Development Maintenance Of Protein Location In Cell Spermatid Differentiation Maintenance Of Protein Location Maintenance Of Location In Cell
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