DPYD and GOPC

Number of citations of the paper that reports this interaction (PMID 24722188)
1

Data Source:
BioGRID (two hybrid, two hybrid)

		DPYD	GOPC
Gene Name		dihydropyrimidine dehydrogenase	golgi-associated PDZ and coiled-coil motif containing
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol	Golgi Membrane Cytoplasm Golgi Apparatus Plasma Membrane Postsynaptic Density Membrane Cell Junction Trans-Golgi Network Transport Vesicle Dendrite Protein Complex Postsynaptic Membrane
	Molecular Function	Dihydroorotate Dehydrogenase Activity Dihydropyrimidine Dehydrogenase (NADP+) Activity Protein Homodimerization Activity Metal Ion Binding Flavin Adenine Dinucleotide Binding NADP Binding 4 Iron, 4 Sulfur Cluster Binding	Small GTPase Regulator Activity Frizzled Binding Protein Binding Protein C-terminus Binding Protein Homodimerization Activity Ion Channel Binding
	Biological Process	Purine Nucleobase Catabolic Process Pyrimidine Nucleobase Metabolic Process Pyrimidine Nucleobase Catabolic Process Thymine Catabolic Process Uracil Catabolic Process Thymidine Catabolic Process UMP Biosynthetic Process Beta-alanine Biosynthetic Process Small Molecule Metabolic Process Pyrimidine Nucleoside Catabolic Process Nucleobase-containing Small Molecule Metabolic Process Oxidation-reduction Process	ER To Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Transport Spermatid Nucleus Differentiation Protein Transport Cytoplasmic Sequestering Of CFTR Protein Apical Protein Localization Regulation Of Catalytic Activity Protein Homooligomerization
Pathways		Pyrimidine catabolism Pyrimidine metabolism Metabolism of nucleotides
Drugs		(5s)-5-Iododihydro-2,4(1h,3h)-Pyrimidinedione Nadph Dihydro-Nicotinamide-Adenine-Dinucleotidephosphate 6-Carboxymethyluracil Flavin-Adenine Dinucleotide Riboflavin Monophosphate Uracil 5-Iodouracil
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Platelet counts ( 21507922) Schizophrenia ( 22688191)	Colorectal cancer ( 23266556)
Protein-Protein Interactions		2 interactors: GOPC LXN	58 interactors: ABCA1 ADRB1 AKIRIN1 ASIC3 BATF BECN1 C17orf67 CCDC102B CD300C CDC42 CDKN2C CERCAM CFTR CLCN3 CSPG5 DPYD FAM90A1 FAM9B FOSL2 FZD5 FZD8 GOLGA3 GRID1 GRID2 HCK IGHG3 JUN KPNA1 LCLAT1 MORN4 MRPL1 MUM1 MYLK MYOCD NUP62 PARK7 PID1 RELA RHOQ RNF183 RNF220 RPL13AP17 RTKN SEMA4G SLC25A18 SPATA8 SSNA1 SSTR5 STARD3 STX6 TGFBR2 VIM VTN ZBTB49 ZNF564 ZNF581 ZNF587 ZSCAN1
Entrez ID		1806	57120
HPRD ID		02036	06024
Ensembl ID		ENSG00000188641	ENSG00000047932
Uniprot IDs		Q12882	Q9HD26
PDB IDs			2DC2 2LOB 4E34 4E35
Enriched GO Terms of Interacting Partners?		Cytoplasmic Sequestering Of CFTR Protein Negative Regulation Of Golgi To Plasma Membrane Protein Transport Regulation Of Golgi To Plasma Membrane Protein Transport Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Apical Protein Localization Negative Regulation Of Protein Localization To Plasma Membrane Cytoplasmic Sequestering Of Protein Asymmetric Protein Localization Detection Of Temperature Stimulus Spermatid Nucleus Differentiation Sensory Perception Of Temperature Stimulus Golgi To Plasma Membrane Transport Regulation Of Establishment Of Protein Localization To Plasma Membrane Regulation Of Protein Localization To Plasma Membrane Post-Golgi Vesicle-mediated Transport Negative Regulation Of Intracellular Protein Transport Sensory Perception Of Pain ER To Golgi Vesicle-mediated Transport Negative Regulation Of Intracellular Transport Nucleus Organization Regulation Of Catalytic Activity Spermatid Development Maintenance Of Protein Location In Cell Spermatid Differentiation Maintenance Of Protein Location Maintenance Of Location In Cell	Cellular Response To Stimulus Cellular Response To Organic Substance Response To External Stimulus Myeloid Leukocyte Differentiation Leukocyte Differentiation Response To Organic Substance Cell Surface Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Regulation Of Protein Phosphorylation Response To Stimulus Cellular Process Cell Communication Positive Regulation Of Cellular Biosynthetic Process Regulation Of Binding Positive Regulation Of Transport Regulation Of Cellular Process Cell Differentiation Regulation Of Membrane Potential Myeloid Dendritic Cell Differentiation Cellular Response To Hormone Stimulus Signal Transduction Blood Vessel Morphogenesis Myeloid Dendritic Cell Activation Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of DNA Binding Response To Extracellular Stimulus Negative Regulation Of Protein Phosphorylation Cell Death Death Positive Regulation Of Gene Expression T-helper 17 Cell Lineage Commitment Response To Lipid Regulation Of Phosphorylation Cellular Localization Membrane Hyperpolarization Negative Regulation Of Cell Proliferation Defense Response Regulation Of Signaling Response To Drug Positive Regulation Of DNA Binding Blood Vessel Development Response To Mechanical Stimulus Response To Stress Signaling Response To Cytokine T-helper 17 Cell Differentiation Dendritic Cell Differentiation Response To Other Organism
Tagcloud ?		advance cdc25a cohorts dach1 demonstrating doi endocrine exerting former functionally fyn gbp1 itpr1 june lyn mcf onc oncogene online overcome parental prkca prlr publication restored s0 subcellular tamoxifen tamr	admissions attained clinicaltrials clinics dbp empowering empowerment equation estimating estimation generalized gov hba1c hong inpatient kong nct01935349 outpatient pep programme registration sbp september service sopc specialist t2dm utilization visits
Tagcloud (Difference) ?		advance cdc25a cohorts dach1 demonstrating doi endocrine exerting former functionally fyn gbp1 itpr1 june lyn mcf onc oncogene online overcome parental prkca prlr publication restored s0 subcellular tamoxifen tamr	admissions attained clinicaltrials clinics dbp empowering empowerment equation estimating estimation generalized gov hba1c hong inpatient kong nct01935349 outpatient pep programme registration sbp september service sopc specialist t2dm utilization visits
Tagcloud (Intersection) ?