DOCK1 and RHOG

Number of citations of the paper that reports this interaction (PMID 12879077)
76

Data Source:
HPRD (in vitro, in vivo)

		DOCK1	RHOG
Gene Name		dedicator of cytokinesis 1	ras homolog family member G
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane	Cytosol Plasma Membrane Focal Adhesion Extracellular Vesicular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding SH3 Domain Binding	GTPase Activity Protein Binding GTP Binding
	Biological Process	Hematopoietic Progenitor Cell Differentiation Phagocytosis, Engulfment Apoptotic Process Signal Transduction Integrin-mediated Signaling Pathway Small GTPase Mediated Signal Transduction Axon Guidance Blood Coagulation Cell Migration Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of GTPase Activity Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway	Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Axon Guidance Blood Coagulation Metabolic Process Positive Regulation Of Cell Proliferation Rac Protein Signal Transduction Actin Cytoskeleton Organization Platelet Activation Activation Of Rac GTPase Activity Positive Regulation Of Transcription, DNA-templated Regulation Of Small GTPase Mediated Signal Transduction Cell Chemotaxis Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Regulation Of Ruffle Assembly
Pathways		Axon guidance Signaling by VEGF DCC mediated attractive signaling Fcgamma receptor (FCGR) dependent phagocytosis Factors involved in megakaryocyte development and platelet production Netrin-1 signaling VEGFA-VEGFR2 Pathway Regulation of actin dynamics for phagocytic cup formation Innate Immune System	Signaling by GPCR Axon guidance Semaphorin interactions Rho GTPase cycle GPCR downstream signaling Signaling by Rho GTPases GPVI-mediated activation cascade G alpha (12/13) signalling events Sema4D in semaphorin signaling Platelet activation, signaling and aggregation Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS		Apolipoprotein Levels ( 23031429)
Protein-Protein Interactions		8 interactors: BCAR1 CRK ELMO1 ELMO2 NCK2 RAC1 RHOG WASF2	19 interactors: ARHGDIA ARHGDIG DOCK1 ECT2 ELMO1 ELMO2 ELMOD2 IQGAP2 KTN1 MAP3K11 MCF2 MCF2L PLD1 SMAD1 SMAD4 TGFBR1 VAV1 VAV2 VAV3
Entrez ID		1793	391
HPRD ID		03240	01537
Ensembl ID		ENSG00000150760	ENSG00000177105
Uniprot IDs		Q14185	P84095 Q6ICQ8
PDB IDs		3L4C
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Actin Cytoskeleton Organization Phagocytosis Fc Receptor Signaling Pathway Positive Regulation Of Immune Response Actin Filament-based Process Regulation Of Immune System Process Rac Protein Signal Transduction Movement Of Cell Or Subcellular Component Cell Migration Regulation Of Immune Response Cell Motility Cell Chemotaxis Platelet Activation Cytoskeleton Organization Lamellipodium Assembly Immune System Process Lamellipodium Organization Chemotaxis Locomotion Endocytosis Cell Activation Innate Immune Response Regulation Of Actin Cytoskeleton Organization Ephrin Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Actin Filament-based Process Signal Transduction Blood Coagulation Regulation Of Cell Projection Assembly Hemostasis Regulation Of Cellular Component Organization Phagocytosis, Engulfment Response To Stress Positive Regulation Of Lamellipodium Assembly Signaling Cell Communication Regulation Of Cytoskeleton Organization Membrane Invagination Positive Regulation Of Lamellipodium Organization Regulation Of Body Fluid Levels	Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Cellular Response To Growth Factor Stimulus Positive Regulation Of Catalytic Activity Response To Growth Factor Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Hydrolase Activity Cell Death Death Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Metabolic Process Phagocytosis Signal Transduction Apoptotic Process Programmed Cell Death Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Signaling Cell Surface Receptor Signaling Pathway Cell Communication Regulation Of Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Intracellular Signal Transduction Positive Regulation Of Ras GTPase Activity Positive Regulation Of Rho GTPase Activity Cellular Response To Stimulus Regulation Of Apoptotic Process Movement Of Cell Or Subcellular Component Fc Receptor Signaling Pathway Regulation Of Rho GTPase Activity Response To Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Ras GTPase Activity Regulation Of Signal Transduction Response To Stress Regulation Of Rho Protein Signal Transduction Apoptotic Signaling Pathway Chemotaxis Defense Response Immune Response-regulating Cell Surface Receptor Signaling Pathway
Tagcloud ?		adhesion adhesions cadherin canine completion contacts coordinate coordination darby dynamic elmo elmo2 exchange gtpase guanine integrin interference localize madin rac recruits reorganization requiring rho screen spreading subsequently unexpected	adam19 adamts16 adamts9 aggf1 altitude altitudes ccbe1 creld1 dahe dhp dwells f2rl1 fgf10 fgf5 foxm gdap1 gna14 involvements jmjd1c nrbf2 parp8 pla2g4a rtel1 sweeps vegfc vps13a wuzhishan wzsp zfpm2
Tagcloud (Difference) ?		adhesion adhesions cadherin canine completion contacts coordinate coordination darby dynamic elmo elmo2 exchange gtpase guanine integrin interference localize madin rac recruits reorganization requiring rho screen spreading subsequently unexpected	adam19 adamts16 adamts9 aggf1 altitude altitudes ccbe1 creld1 dahe dhp dwells f2rl1 fgf10 fgf5 foxm gdap1 gna14 involvements jmjd1c nrbf2 parp8 pla2g4a rtel1 sweeps vegfc vps13a wuzhishan wzsp zfpm2
Tagcloud (Intersection) ?