DOCK1 and CYTH2

Number of citations of the paper that reports this interaction (PubMedID 20016009)
56

Data Source:
BioGRID (pull down)

		DOCK1	CYTH2
Description		dedicator of cytokinesis 1	cytohesin 2
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Guanyl-nucleotide Exchange Factor Complex Postsynapse Glutamatergic Synapse	Golgi Membrane Cytoplasm Cytosol Plasma Membrane Adherens Junction Bicellular Tight Junction Membrane Growth Cone Cell Projection Anchoring Junction
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding SH3 Domain Binding Small GTPase Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Lipid Binding Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Phagocytosis Phagocytosis, Engulfment Apoptotic Process Signal Transduction Integrin-mediated Signaling Pathway Small GTPase-mediated Signal Transduction Myoblast Fusion Positive Regulation Of Epithelial Cell Migration Cell Migration Regulation Of Postsynapse Assembly Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Endocytosis Actin Cytoskeleton Organization Regulation Of ARF Protein Signal Transduction
Pathways		Regulation of actin dynamics for phagocytic cup formation DCC mediated attractive signaling DCC mediated attractive signaling VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle FCGR3A-mediated phagocytosis Factors involved in megakaryocyte development and platelet production	Intra-Golgi traffic
Drugs			Inositol 1,3,4,5-Tetrakisphosphate Formic acid 1D-myo-inositol 1,4,5-trisphosphate S,S-(2-Hydroxyethyl)Thiocysteine Brefeldin A
Diseases
GWAS		Airway wall thickness ( 25517131) Apolipoprotein Levels ( 23031429) Body mass index ( 25673413) Body mass index (change over time) in gastrointestinal cancer ( 28044437) Body mass index (change over time) in gastrointestinal cancer or chronic obstructive pulmonary disease ( 28044437) BRCA1/2-negative high-risk breast cancer ( 30323354) Chronotype ( 30696823) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Homeostasis model assessment of insulin resistance in less-fat diet ( 30327367) Response to cytidine analogues (gemcitabine) ( 24483146) Response to TNF inhibitor in rheumatoid arthritis (change in disease activity score) ( 30166627) Response to TNF inhibitor in rheumatoid arthritis (change in tender 28-joint count) ( 30166627) Social communication problems ( 24564958) Weight ( 28552196)	Abstraction and mental flexibility ( 31596458)
Interacting Genes		11 interacting genes: BCAR1 CRK CYTH2 ELMO1 ELMO2 NCK2 PRKACA RAC1 RHOG TAMALIN WASF2	30 interacting genes: ADORA2A ALDOA APC ARF1 ARF6 ARFGAP1 ARL4A ARL4D ARRB1 ARRB2 ATP6V0A1 ATP6V0A2 ATP6V0A4 CCDC120 CUX1 CYTIP DOCK1 GGA3 GNAQ IPCEF1 ITGB2 MAPK6 PIK3CA PNPLA2 PRKCA PRKCB PRKCG SNCA TCIRG1 TRIM23
Entrez ID		1793	9266
HPRD ID		03240	03925
Ensembl ID		ENSG00000150760	ENSG00000105443
Uniprot IDs		A0A096LNH6 A0A2X0U2H5 B2RUU3 Q14185	Q99418
PDB IDs		3L4C	1PBV 1R8M 1R8Q 1R8S 1S9D 4JMI 4JMO 4JWL 4JXH 4L5M 4Z21
Enriched GO Terms of Interacting Partners?		SH3 Domain Binding Rac Protein Signal Transduction Actin Filament Organization Actin Cytoskeleton Organization Cell Chemotaxis Actin Filament-based Process Cell Motility Regulation Of Cellular Component Organization Supramolecular Fiber Organization Lamellipodium Assembly Regulation Of Postsynapse Assembly Lamellipodium Organization Chemotaxis Cell Migration Regulation Of Actin Cytoskeleton Organization Locomotion Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Hepatocyte Growth Factor Receptor Signaling Pathway Regulation Of Actin Filament-based Process Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Receptor Tyrosine Kinase Binding Positive Regulation Of Receptor Clustering Endocytosis Postsynapse Positive Regulation Of Protein Localization To Membrane Response To Hepatocyte Growth Factor Regulation Of Cell Junction Assembly Small GTPase-mediated Signal Transduction Regulation Of Receptor Clustering Regulation Of Cytoskeleton Organization Actin Cytoskeleton Glutamatergic Synapse Regulation Of Bicellular Tight Junction Assembly Protein Kinase A Regulatory Subunit Binding Cytoskeleton Organization Positive Regulation Of Lamellipodium Assembly Import Into Cell Regulation Of Cell Shape Regulation Of Postsynapse Organization Regulation Of Ruffle Assembly Cytosol Neuron Migration Phagocytosis, Engulfment Signaling Receptor Complex Adaptor Activity Positive Regulation Of Lamellipodium Organization Establishment Or Maintenance Of Cell Polarity Regulation Of Synapse Assembly Regulation Of Protein Localization To Membrane Regulation Of Lamellipodium Assembly Positive Regulation Of Supramolecular Fiber Organization	Vesicle-mediated Transport Proton-transporting V-type ATPase, V0 Domain Vacuolar Proton-transporting V-type ATPase, V0 Domain Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Biological Quality Plasma Membrane Vacuolar Proton-transporting V-type ATPase Complex Proton-transporting V-type ATPase Complex Regulation Of Vesicle-mediated Transport Proton-transporting ATPase Activity, Rotational Mechanism Vacuolar Acidification Endocytosis Positive Regulation Of Protein Localization Intracellular Protein Localization Regulation Of Endocytosis Cellular Homeostasis Membrane Protein Transport Intracellular PH Reduction Angiotensin Receptor Binding Histone H3T6 Kinase Activity Regulation Of Protein Localization Diacylglycerol-dependent Serine/threonine Kinase Activity Lysosomal Membrane Intracellular Chemical Homeostasis Regulation Of Secretion By Cell Receptor Internalization Establishment Of Protein Localization Import Into Cell Endosome Membrane Regulation Of Transport Regulation Of Secretion Phagocytic Vesicle Membrane Positive Regulation Of Secretion By Cell ATPase Binding Regulation Of Intracellular PH Regulation Of Neurotransmitter Secretion Chemical Homeostasis Negative Regulation Of Dopamine Metabolic Process Protein Kinase C Signaling Regulation Of Cellular PH Monoatomic Cation Homeostasis Positive Regulation Of Secretion GTPase Activity Regulation Of Exocytosis Apoptotic Process Monoatomic Ion Homeostasis Phagocytosis Regulation Of PH Negative Regulation Of Catecholamine Metabolic Process
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