DOCK1 and ELMO2

Number of citations of the paper that reports this interaction (PMID 11703939)
43

Data Source:
HPRD (two hybrid, in vitro)

		DOCK1	ELMO2
Gene Name		dedicator of cytokinesis 1	engulfment and cell motility 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane	Cytoplasm Cytosol Cytoskeleton Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding SH3 Domain Binding	Protein Binding SH3 Domain Binding Receptor Tyrosine Kinase Binding
	Biological Process	Hematopoietic Progenitor Cell Differentiation Phagocytosis, Engulfment Apoptotic Process Signal Transduction Integrin-mediated Signaling Pathway Small GTPase Mediated Signal Transduction Axon Guidance Blood Coagulation Cell Migration Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of GTPase Activity Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway	Apoptotic Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Chemotaxis
Pathways		Axon guidance Signaling by VEGF DCC mediated attractive signaling Fcgamma receptor (FCGR) dependent phagocytosis Factors involved in megakaryocyte development and platelet production Netrin-1 signaling VEGFA-VEGFR2 Pathway Regulation of actin dynamics for phagocytic cup formation Innate Immune System	Signaling by VEGF Fcgamma receptor (FCGR) dependent phagocytosis VEGFA-VEGFR2 Pathway Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS		Apolipoprotein Levels ( 23031429)
Protein-Protein Interactions		8 interactors: BCAR1 CRK ELMO1 ELMO2 NCK2 RAC1 RHOG WASF2	2 interactors: DOCK1 RHOG
Entrez ID		1793	63916
HPRD ID		03240	12103
Ensembl ID		ENSG00000150760	ENSG00000062598
Uniprot IDs		Q14185	B4DRL5 B4DZ20 F5GZP8 Q7Z5G9 Q96JJ3
PDB IDs		3L4C
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Actin Cytoskeleton Organization Phagocytosis Fc Receptor Signaling Pathway Positive Regulation Of Immune Response Actin Filament-based Process Regulation Of Immune System Process Rac Protein Signal Transduction Movement Of Cell Or Subcellular Component Cell Migration Regulation Of Immune Response Cell Motility Cell Chemotaxis Platelet Activation Cytoskeleton Organization Lamellipodium Assembly Immune System Process Lamellipodium Organization Chemotaxis Locomotion Endocytosis Cell Activation Innate Immune Response Regulation Of Actin Cytoskeleton Organization Ephrin Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Actin Filament-based Process Signal Transduction Blood Coagulation Regulation Of Cell Projection Assembly Hemostasis Regulation Of Cellular Component Organization Phagocytosis, Engulfment Response To Stress Positive Regulation Of Lamellipodium Assembly Signaling Cell Communication Regulation Of Cytoskeleton Organization Membrane Invagination Positive Regulation Of Lamellipodium Organization Regulation Of Body Fluid Levels	Axon Guidance Blood Coagulation Hemostasis Axonogenesis Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Wound Healing Chemotaxis Small GTPase Mediated Signal Transduction Neuron Projection Morphogenesis Response To Wounding Cell Morphogenesis Involved In Differentiation Positive Regulation Of GTPase Activity Activation Of Rac GTPase Activity Phagocytosis, Engulfment Regulation Of GTPase Activity Neuron Projection Development Cell Migration Cell Projection Morphogenesis Cell Part Morphogenesis Cell Motility Regulation Of Ruffle Assembly Membrane Invagination Rac Protein Signal Transduction Neuron Development Positive Regulation Of Hydrolase Activity Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Cell Morphogenesis Positive Regulation Of Protein Localization To Plasma Membrane Neuron Differentiation Cell Projection Organization Locomotion Activation Of Rho GTPase Activity Regulation Of Establishment Of Protein Localization To Plasma Membrane Movement Of Cell Or Subcellular Component Positive Regulation Of Catalytic Activity Regulation Of Protein Localization To Plasma Membrane Generation Of Neurons Activation Of Ras GTPase Activity Positive Regulation Of Rac GTPase Activity Rho Protein Signal Transduction Neurogenesis Cell Development Response To External Stimulus Intracellular Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Nervous System Development Regulation Of Cell Projection Assembly Regulation Of Catalytic Activity
Tagcloud ?		adhesion adhesions cadherin canine completion contacts coordinate coordination darby dynamic elmo elmo2 exchange gtpase guanine integrin interference localize madin rac recruits reorganization requiring rho screen spreading subsequently unexpected	adhesion adhesions cadherin canine completion contacts coordinate coordination darby dock dock1 dynamic exchange gtpase guanine integrin interference localize madin rac recruits reorganization requiring rho screen spreading subsequently unexpected
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		adhesion adhesions cadherin canine completion contacts coordinate coordination darby dock dock1 dynamic elmo elmo2 exchange gtpase guanine integrin interference localize madin rac recruits reorganization requiring rho screen spreading subsequently unexpected