DOCK1 and ELMO2

Number of citations of the paper that reports this interaction (PubMedID 11703939)
0

Data Source:
HPRD (two hybrid, in vitro)

		DOCK1	ELMO2
Description		dedicator of cytokinesis 1	engulfment and cell motility 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Guanyl-nucleotide Exchange Factor Complex Postsynapse Glutamatergic Synapse	Cytoplasm Cytosol Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding SH3 Domain Binding Small GTPase Binding	Protein Binding SH3 Domain Binding Receptor Tyrosine Kinase Binding
	Biological Process	Phagocytosis Phagocytosis, Engulfment Apoptotic Process Signal Transduction Integrin-mediated Signaling Pathway Small GTPase-mediated Signal Transduction Myoblast Fusion Positive Regulation Of Epithelial Cell Migration Cell Migration Regulation Of Postsynapse Assembly Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Phagocytosis Apoptotic Process Actin Filament Organization Cell Motility Cell Chemotaxis
Pathways		Regulation of actin dynamics for phagocytic cup formation DCC mediated attractive signaling DCC mediated attractive signaling VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle FCGR3A-mediated phagocytosis Factors involved in megakaryocyte development and platelet production	Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases RHOG GTPase cycle FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Airway wall thickness ( 25517131) Apolipoprotein Levels ( 23031429) Body mass index ( 25673413) Body mass index (change over time) in gastrointestinal cancer ( 28044437) Body mass index (change over time) in gastrointestinal cancer or chronic obstructive pulmonary disease ( 28044437) BRCA1/2-negative high-risk breast cancer ( 30323354) Chronotype ( 30696823) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Homeostasis model assessment of insulin resistance in less-fat diet ( 30327367) Response to cytidine analogues (gemcitabine) ( 24483146) Response to TNF inhibitor in rheumatoid arthritis (change in disease activity score) ( 30166627) Response to TNF inhibitor in rheumatoid arthritis (change in tender 28-joint count) ( 30166627) Social communication problems ( 24564958) Weight ( 28552196)
Interacting Genes		11 interacting genes: BCAR1 CRK CYTH2 ELMO1 ELMO2 NCK2 PRKACA RAC1 RHOG TAMALIN WASF2	3 interacting genes: DOCK1 DOCK4 RHOG
Entrez ID		1793	63916
HPRD ID		03240	12103
Ensembl ID		ENSG00000150760	ENSG00000062598
Uniprot IDs		A0A096LNH6 A0A2X0U2H5 B2RUU3 Q14185	Q96JJ3
PDB IDs		3L4C	6IDX 6IE1
Enriched GO Terms of Interacting Partners?		SH3 Domain Binding Rac Protein Signal Transduction Actin Filament Organization Actin Cytoskeleton Organization Cell Chemotaxis Actin Filament-based Process Cell Motility Regulation Of Cellular Component Organization Supramolecular Fiber Organization Lamellipodium Assembly Regulation Of Postsynapse Assembly Lamellipodium Organization Chemotaxis Cell Migration Regulation Of Actin Cytoskeleton Organization Locomotion Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Hepatocyte Growth Factor Receptor Signaling Pathway Regulation Of Actin Filament-based Process Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Receptor Tyrosine Kinase Binding Positive Regulation Of Receptor Clustering Endocytosis Postsynapse Positive Regulation Of Protein Localization To Membrane Response To Hepatocyte Growth Factor Regulation Of Cell Junction Assembly Small GTPase-mediated Signal Transduction Regulation Of Receptor Clustering Regulation Of Cytoskeleton Organization Actin Cytoskeleton Glutamatergic Synapse Regulation Of Bicellular Tight Junction Assembly Protein Kinase A Regulatory Subunit Binding Cytoskeleton Organization Positive Regulation Of Lamellipodium Assembly Import Into Cell Regulation Of Cell Shape Regulation Of Postsynapse Organization Regulation Of Ruffle Assembly Cytosol Neuron Migration Phagocytosis, Engulfment Signaling Receptor Complex Adaptor Activity Positive Regulation Of Lamellipodium Organization Establishment Or Maintenance Of Cell Polarity Regulation Of Synapse Assembly Regulation Of Protein Localization To Membrane Regulation Of Lamellipodium Assembly Positive Regulation Of Supramolecular Fiber Organization	Regulation Of Postsynapse Assembly Regulation Of Postsynapse Organization Regulation Of Synapse Assembly Postsynapse Regulation Of Cell Junction Assembly Small GTPase-mediated Signal Transduction Regulation Of Synapse Organization Glutamatergic Synapse Intracellular Signaling Cassette SH3 Domain Binding Cell Migration Cell Motility Cell Chemotaxis Guanyl-nucleotide Exchange Factor Activity Negative Regulation Of Vascular Associated Smooth Muscle Contraction GTPase Activator Activity Small GTPase Binding Intracellular Signal Transduction Chemotaxis Locomotion Guanyl-nucleotide Exchange Factor Complex Stereocilium Bundle Regulation Of Vascular Associated Smooth Muscle Contraction Negative Regulation Of Smooth Muscle Contraction Negative Regulation Of Vasoconstriction Regulation Of Cellular Component Organization Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Negative Regulation Of Muscle Contraction Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Activation Of GTPase Activity Rac Protein Signal Transduction Myoblast Fusion Regulation Of Ruffle Assembly Phagocytosis, Engulfment Cell-cell Fusion Syncytium Formation By Plasma Membrane Fusion Organelle Syncytium Formation Positive Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Stereocilium Cortical Cytoskeleton Organization Membrane Invagination Positive Regulation Of Epithelial Cell Migration Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Smooth Muscle Contraction
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