DOCK1 and WASF2

Number of citations of the paper that reports this interaction (PMID 11773052)
6

Data Source:
HPRD (in vivo, in vitro)

		DOCK1	WASF2
Gene Name		dedicator of cytokinesis 1	WAS protein family, member 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane	Ruffle Intracellular Early Endosome Cytosol Cell-cell Junction Actin Cytoskeleton Lamellipodium SCAR Complex Extracellular Vesicular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding SH3 Domain Binding	Actin Binding Protein Binding Protein Complex Binding
	Biological Process	Hematopoietic Progenitor Cell Differentiation Phagocytosis, Engulfment Apoptotic Process Signal Transduction Integrin-mediated Signaling Pathway Small GTPase Mediated Signal Transduction Axon Guidance Blood Coagulation Cell Migration Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of GTPase Activity Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway	Angiogenesis Ameboidal-type Cell Migration Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Lamellipodium Assembly Actin Cytoskeleton Organization Actin Filament-based Movement Megakaryocyte Development Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Stress Fiber Assembly Lamellipodium Morphogenesis
Pathways		Axon guidance Signaling by VEGF DCC mediated attractive signaling Fcgamma receptor (FCGR) dependent phagocytosis Factors involved in megakaryocyte development and platelet production Netrin-1 signaling VEGFA-VEGFR2 Pathway Regulation of actin dynamics for phagocytic cup formation Innate Immune System	Signaling by VEGF Fcgamma receptor (FCGR) dependent phagocytosis VEGFA-VEGFR2 Pathway Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS		Apolipoprotein Levels ( 23031429)
Protein-Protein Interactions		8 interactors: BCAR1 CRK ELMO1 ELMO2 NCK2 RAC1 RHOG WASF2	23 interactors: ABI1 ABI2 ABI3 ABL1 ACTB ACTR2 ACTR3 APBB1 ARPC3 BAIAP2 BTK CDC42 CYFIP2 DOCK1 FYN GAS7 GRB2 ITSN2 NCKAP1 PACSIN1 PRPF40A PSTPIP1 TCERG1
Entrez ID		1793	10163
HPRD ID		03240	05796
Ensembl ID		ENSG00000150760	ENSG00000158195
Uniprot IDs		Q14185	Q9Y6W5
PDB IDs		3L4C	2A40
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Actin Cytoskeleton Organization Phagocytosis Fc Receptor Signaling Pathway Positive Regulation Of Immune Response Actin Filament-based Process Regulation Of Immune System Process Rac Protein Signal Transduction Movement Of Cell Or Subcellular Component Cell Migration Regulation Of Immune Response Cell Motility Cell Chemotaxis Platelet Activation Cytoskeleton Organization Lamellipodium Assembly Immune System Process Lamellipodium Organization Chemotaxis Locomotion Endocytosis Cell Activation Innate Immune Response Regulation Of Actin Cytoskeleton Organization Ephrin Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Actin Filament-based Process Signal Transduction Blood Coagulation Regulation Of Cell Projection Assembly Hemostasis Regulation Of Cellular Component Organization Phagocytosis, Engulfment Response To Stress Positive Regulation Of Lamellipodium Assembly Signaling Cell Communication Regulation Of Cytoskeleton Organization Membrane Invagination Positive Regulation Of Lamellipodium Organization Regulation Of Body Fluid Levels	Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Endocytosis Phagocytosis Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Innate Immune Response Positive Regulation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Projection Organization Vesicle-mediated Transport Neuron Projection Development Cell Projection Morphogenesis Neuron Projection Morphogenesis Cell Part Morphogenesis Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Neuron Development Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Actin Filament Organization Cell Morphogenesis Defense Response Neuron Differentiation Cell Development Movement Of Cell Or Subcellular Component Axonogenesis Regulation Of Immune System Process Axon Guidance Axon Development Cell Morphogenesis Involved In Neuron Differentiation Actin Cytoskeleton Organization Actin Filament-based Process Generation Of Neurons Locomotion Cell Morphogenesis Involved In Differentiation Neurogenesis Immune System Process Cytoskeleton Organization Chemotaxis Nervous System Development Regulation Of Cellular Component Organization Anatomical Structure Morphogenesis Regulation Of Cytoskeleton Organization Ephrin Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization
Tagcloud ?		adhesion adhesions cadherin canine completion contacts coordinate coordination darby dynamic elmo elmo2 exchange gtpase guanine integrin interference localize madin rac recruits reorganization requiring rho screen spreading subsequently unexpected
Tagcloud (Difference) ?		adhesion adhesions cadherin canine completion contacts coordinate coordination darby dynamic elmo elmo2 exchange gtpase guanine integrin interference localize madin rac recruits reorganization requiring rho screen spreading subsequently unexpected
Tagcloud (Intersection) ?