TNFSF12

Gene Name		tumor necrosis factor (ligand) superfamily, member 12
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Gene Ontology Annotations	Cellular Component	Extracellular Space Integral Component Of Plasma Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding
	Biological Process	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Apoptotic Process Immune Response Signal Transduction Cell Differentiation Endothelial Cell Migration Positive Regulation Of Protein Catabolic Process Positive Regulation Of Angiogenesis Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Protein-protein Interactions		4 interactors: AGGF1 DDIT3 TNFRSF12A TNFRSF25
Entrez ID		8742
HPRD ID		04074
Ensembl ID		ENSG00000239697
Uniprot IDs		O43508 Q4ACW9
PDB IDs		4HT1
Enriched GO Terms of Interacting Partners?		Apoptotic Signaling Pathway Blood Vessel Development Vasculature Development Negative Regulation Of Determination Of Dorsal Identity Cardiovascular System Development Apoptotic Process Programmed Cell Death Regulation Of Transcription Involved In Anterior/posterior Axis Specification Cell Death Death Substrate-dependent Cell Migration, Cell Attachment To Substrate Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Regulation Of Apoptotic Process Regulation Of Cell Death Angiogenesis ER Overload Response Blood Vessel Morphogenesis MRNA Transcription From RNA Polymerase II Promoter Blood Vessel Maturation MRNA Transcription Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Myoblast Differentiation Positive Regulation Of Cell Death Positive Regulation Of Interleukin-8 Production Release Of Sequestered Calcium Ion Into Cytosol Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Substrate-dependent Cell Migration Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Sequestering Of Calcium Ion Positive Regulation Of Axon Extension Regulation Of Myoblast Differentiation Negative Regulation Of Muscle Cell Differentiation Calcium Ion Transport Into Cytosol Cytosolic Calcium Ion Transport Cell Surface Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Nuclease Activity Regulation Of DNA-templated Transcription In Response To Stress
Tagcloud ?		2alpha 2beta abcb1b additive biexponential clearance designated dimeric erb3 fn14 fused gelonin hsgz humanized id immunotoxin inducer kills luc mcf7 mdr mdr1 pharmacokinetic synergistic t1 toxin translated tweak