TNFSF12 and TNFRSF12A

Number of citations of the paper that reports this interaction (PubMedID 12529173)
45

Data Source:
HPRD (in vivo)

		TNFSF12	TNFRSF12A
Description		TNF superfamily member 12	TNF receptor superfamily member 12A
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Perinuclear Region Of Cytoplasm	Ruffle Plasma Membrane Cell Surface Membrane
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding	Protein Binding
	Biological Process	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Apoptotic Process Immune Response Signal Transduction Cell Differentiation Endothelial Cell Migration Positive Regulation Of Protein Catabolic Process Positive Regulation Of Angiogenesis Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Angiogenesis Apoptotic Process Substrate-dependent Cell Migration, Cell Attachment To Substrate Cell Adhesion Cell Differentiation Positive Regulation Of Apoptotic Process Regulation Of Angiogenesis Positive Regulation Of Axon Extension Regulation Of Wound Healing Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Apolipoprotein A1 levels ( 32203549) Atrial fibrillation ( 29892015 30061737) Brain morphology (MOSTest) ( 32665545) Chin dimples ( 27182965) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Emotional recognition ( 31596458) HDL cholesterol levels ( 32203549) Myopia ( 27182965) Plateletcrit ( 32888494) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		6 interacting genes: AGGF1 DDIT3 LMNA SGTA TNFRSF12A TNFRSF25	8 interacting genes: KRTAP3-3 RAC1 SLC30A2 TNFSF12 TRAF1 TRAF2 TRAF3 TRAF5
Entrez ID		8742	51330
HPRD ID		04074	05801
Ensembl ID		ENSG00000239697	ENSG00000006327
Uniprot IDs		O43508 Q4ACW9	Q9NP84
PDB IDs		4HT1	2EQP 2KMZ 2RPJ
Enriched GO Terms of Interacting Partners?		Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Negative Regulation Of Determination Of Dorsal Identity Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress CHOP-ATF4 Complex CHOP-ATF3 Complex Apoptotic Signaling Pathway Establishment Of Protein Localization To Organelle DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina TRC Complex Substrate-dependent Cell Migration, Cell Attachment To Substrate Positive Regulation Of Apoptotic Signaling Pathway Involuntary Skeletal Muscle Contraction CHOP-C/EBP Complex Diaphragm Contraction Cellular Response To Nitrosative Stress Identical Protein Binding Vascular Associated Smooth Muscle Cell Migration Regulation Of Extrinsic Apoptotic Signaling Pathway Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity BAT3 Complex Binding GDF15-GFRAL Signaling Pathway Lamin Filament Nuclear Pore Localization Cell Death ATF6-mediated Unfolded Protein Response HRI-mediated Signaling Apoptotic Process Response To Endoplasmic Reticulum Stress Blood Vessel Maturation Negative Regulation Of Interleukin-4 Production Response To Nitrosative Stress Programmed Cell Death Smooth Muscle Cell Proliferation Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of ERAD Pathway Transcription Regulator Activator Activity PERK-mediated Unfolded Protein Response ER Overload Response Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway CAMP Response Element Binding Protein Binding Response To Caloric Restriction Leucine Zipper Domain Binding Ventricular Cardiac Muscle Cell Development Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress	Thioesterase Binding Tumor Necrosis Factor Receptor Binding Tumor Necrosis Factor-mediated Signaling Pathway CD40 Receptor Complex Signaling Adaptor Activity Regulation Of DNA-binding Transcription Factor Activity Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Binding Positive Regulation Of NF-kappaB Transcription Factor Activity CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Cytoplasmic Side Of Plasma Membrane Positive Regulation Of DNA-binding Transcription Factor Activity Apoptotic Process Cell Death Programmed Cell Death Cytokine-mediated Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Involved In Regulation Of Gene Expression Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Extrinsic Apoptotic Signaling Pathway TORC2 Complex Disassembly MRNA Stabilization Ubiquitin Protein Ligase Activity Zinc Ion Import Into Zymogen Granule Zinc Ion Import Into Mitochondrion Zinc Ion Import Into Secretory Vesicle Identical Protein Binding Regulation Of Signal Transduction Regulation Of Apoptotic Signaling Pathway Negative Regulation Of MRNA Catabolic Process RNA Stabilization Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Protein Kinase Binding Cerebral Cortex GABAergic Interneuron Development Regulation Of Intracellular Signal Transduction Protein Phosphatase Binding Negative Regulation Of RNA Catabolic Process TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Negative Regulation Of MRNA Metabolic Process Ubiquitin Ligase Complex Regulation Of Cell Communication
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