TNFSF12 and TNFRSF25

Number of citations of the paper that reports this interaction (PMID 11094155)
13

Data Source:
HPRD (in vivo)

		TNFSF12	TNFRSF25
Gene Name		tumor necrosis factor (ligand) superfamily, member 12	tumor necrosis factor receptor superfamily, member 25
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Integral Component Of Plasma Membrane Perinuclear Region Of Cytoplasm	Extracellular Region Cytosol Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding	Receptor Activity Tumor Necrosis Factor-activated Receptor Activity
	Biological Process	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Apoptotic Process Immune Response Signal Transduction Cell Differentiation Endothelial Cell Migration Positive Regulation Of Protein Catabolic Process Positive Regulation Of Angiogenesis Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Apoptotic Process Signal Transduction Cell Surface Receptor Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: AGGF1 DDIT3 TNFRSF12A TNFRSF25	8 interactors: BAG4 DAP3 MAPK1 TNFRSF1A TNFSF12 TNFSF15 TRADD TRAF2
Entrez ID		8742	8718
HPRD ID		04074	04532
Ensembl ID		ENSG00000239697	ENSG00000215788
Uniprot IDs		O43508 Q4ACW9	Q93038
PDB IDs		4HT1
Enriched GO Terms of Interacting Partners?		Apoptotic Signaling Pathway Blood Vessel Development Vasculature Development Negative Regulation Of Determination Of Dorsal Identity Cardiovascular System Development Apoptotic Process Programmed Cell Death Regulation Of Transcription Involved In Anterior/posterior Axis Specification Cell Death Death Substrate-dependent Cell Migration, Cell Attachment To Substrate Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Regulation Of Apoptotic Process Regulation Of Cell Death Angiogenesis ER Overload Response Blood Vessel Morphogenesis MRNA Transcription From RNA Polymerase II Promoter Blood Vessel Maturation MRNA Transcription Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Myoblast Differentiation Positive Regulation Of Cell Death Positive Regulation Of Interleukin-8 Production Release Of Sequestered Calcium Ion Into Cytosol Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Substrate-dependent Cell Migration Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Sequestering Of Calcium Ion Positive Regulation Of Axon Extension Regulation Of Myoblast Differentiation Negative Regulation Of Muscle Cell Differentiation Calcium Ion Transport Into Cytosol Cytosolic Calcium Ion Transport Cell Surface Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Nuclease Activity Regulation Of DNA-templated Transcription In Response To Stress	Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Cellular Response To Tumor Necrosis Factor Positive Regulation Of Intracellular Signal Transduction Response To Tumor Necrosis Factor Protein Heterooligomerization Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Response To Cytokine Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Response To Cytokine Positive Regulation Of Protein Phosphorylation Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Signal Transduction Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Phosphorylation Activation Of Cysteine-type Endopeptidase Activity Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Modification Process Regulation Of Signaling Zymogen Activation Signal Transduction Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Oligomerization Positive Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Metabolic Process Positive Regulation Of Endopeptidase Activity Signaling Cell Communication Positive Regulation Of Peptidase Activity Regulation Of Phosphorylation Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of NF-kappaB-inducing Kinase Activity Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Response To Epidermal Growth Factor Regulation Of Phosphorus Metabolic Process
Tagcloud ?		2alpha 2beta abcb1b additive biexponential clearance designated dimeric erb3 fn14 fused gelonin hsgz humanized id immunotoxin inducer kills luc mcf7 mdr mdr1 pharmacokinetic synergistic t1 toxin translated tweak	asp bel7404 carboxy cip1 cited2 clonogenicity glu granzyme hccs hep3b ink4b kip1 lo2 maspin metallopeptidase nontumor oligonucleotide ontology p15 peroxisome ppargamma proapoptotic proinvasion proliferator rosiglitazone suppressive transactivator wat1
Tagcloud (Difference) ?		2alpha 2beta abcb1b additive biexponential clearance designated dimeric erb3 fn14 fused gelonin hsgz humanized id immunotoxin inducer kills luc mcf7 mdr mdr1 pharmacokinetic synergistic t1 toxin translated tweak	asp bel7404 carboxy cip1 cited2 clonogenicity glu granzyme hccs hep3b ink4b kip1 lo2 maspin metallopeptidase nontumor oligonucleotide ontology p15 peroxisome ppargamma proapoptotic proinvasion proliferator rosiglitazone suppressive transactivator wat1
Tagcloud (Intersection) ?