BACH1 and ATF2

Number of citations of the paper that reports this interaction (PMID 23661758)
2

Data Source:
BioGRID (fluorescent resonance energy transfer)

		BACH1	ATF2
Gene Name		BTB and CNC homology 1, basic leucine zipper transcription factor 1	activating transcription factor 2
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Mitochondrial Outer Membrane Site Of Double-strand Break
	Molecular Function	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Heme Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Activating Transcription Factor Binding Enhancer Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding CAMP Response Element Binding Protein Binding Protein Kinase Binding CAMP Response Element Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Outflow Tract Morphogenesis Chromatin Organization Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Response To Osmotic Stress Cellular Response To DNA Damage Stimulus Histone Acetylation Intra-S DNA Damage Checkpoint Positive Regulation Of Transforming Growth Factor Beta2 Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Innate Immune Response Fat Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Stress-activated MAPK Cascade Adipose Tissue Development Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Pathways			Organelle biogenesis and maintenance Toll Like Receptor 7/8 (TLR7/8) Cascade HATs acetylate histones Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade Activation of the AP-1 family of transcription factors MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Innate Immune System Chromatin organization TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade MyD88-independent cascade Mitochondrial biogenesis Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Chromatin modifying enzymes Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade MAPK targets/ Nuclear events mediated by MAP kinases Transcriptional activation of mitochondrial biogenesis
Drugs
Diseases
GWAS		Pancreatic cancer ( 22158540) Visceral fat ( 22589738)
Protein-Protein Interactions		11 interactors: ANAPC5 ATF2 DDIT3 HMMR MAFB MAFF MAFG MAFK PATZ1 RBCK1 TP53	55 interactors: APP AR ATF3 ATF4 ATF7 BACH1 BATF BATF3 CCDC6 CCND1 CEBPA CEBPB CEBPG CREB5 CSNK2A1 CSNK2A2 DDIT3 EDF1 ETS1 EXOSC8 FOS FOSL1 GTF2F2 H2AFY HIST2H2BE HMGA1 IRF2BP1 JDP2 JUN KIFC3 MAPK1 MAPK10 MAPK11 MAPK13 MAPK14 MAPK8 MAPK9 MAPKAPK5 MLH1 NBN NCOA6 PML PRKCE RB1 RPS6KA5 RUVBL2 SMAD3 SMAD4 SRA1 SUMO1 THRB UBE2I UTF1 XPO1 YY1
Entrez ID		571	1386
HPRD ID		04127	00443
Ensembl ID		ENSG00000156273	ENSG00000115966
Uniprot IDs		O14867 Q6ICU0	A4D7V5 P15336
PDB IDs		2IHC	1BHI 1T2K 4H36
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process ER Overload Response Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Gene Expression Regulation Of Gene Expression Positive Regulation Of Mitochondrial Membrane Permeability Regulation Of Nitrogen Compound Metabolic Process Blood Coagulation Cellular Macromolecule Biosynthetic Process Hemostasis Macromolecule Biosynthetic Process Negative Regulation Of Cell Cycle Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process T Cell Differentiation Mitotic Cell Cycle Checkpoint Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Mitochondrial Membrane Permeability Regulation Of Body Fluid Levels Regulation Of Membrane Permeability Wound Healing Negative Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Lymphocyte Differentiation Regulation Of Epidermal Cell Differentiation Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Response To Wounding Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process T Cell Aggregation T Cell Activation Lymphocyte Aggregation Biosynthetic Process Leukocyte Aggregation Anatomical Structure Development Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Mitochondrial Membrane Organization Leukocyte Cell-cell Adhesion Positive Regulation Of Gene Expression	Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Regulation Of Gene Expression RNA Biosynthetic Process RNA Metabolic Process Gene Expression Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Biosynthetic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Biosynthetic Process Positive Regulation Of Protein Metabolic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Cellular Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Response To External Stimulus Negative Regulation Of Gene Expression Toll-like Receptor 3 Signaling Pathway
Tagcloud ?		architectural architecture bach2 bear btb bzip constitutes erythroleukemic globin heterodimer heterodimers holocomplex implicate lcr maf mafk mare mares mel multimeric multivalent nrf1 nucleoprotein obligate opening poz properly zipper	assayed atp compete competes diphosphorylated enzyme equal equally gly gst homogeneously ic50 inactive km monophosphorylated p38 preparations pyridinylimidazole pyridinylimidazoles s2 sb202190 sb203580 thr threonine transducing tritiated tyr ubiquitous unphosphorylated
Tagcloud (Difference) ?		architectural architecture bach2 bear btb bzip constitutes erythroleukemic globin heterodimer heterodimers holocomplex implicate lcr maf mafk mare mares mel multimeric multivalent nrf1 nucleoprotein obligate opening poz properly zipper	assayed atp compete competes diphosphorylated enzyme equal equally gly gst homogeneously ic50 inactive km monophosphorylated p38 preparations pyridinylimidazole pyridinylimidazoles s2 sb202190 sb203580 thr threonine transducing tritiated tyr ubiquitous unphosphorylated
Tagcloud (Intersection) ?