PTPRK and PTPRM

Number of citations of the paper that reports this interaction (PubMedID 28675297)
33

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		PTPRK	PTPRM
Description		protein tyrosine phosphatase receptor type K	protein tyrosine phosphatase receptor type M
Image
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Adherens Junction Cell Surface Membrane Cell Junction Leading Edge Membrane Anchoring Junction	Cytoplasm Plasma Membrane Cell-cell Junction Adherens Junction Membrane Lamellipodium Perinuclear Region Of Cytoplasm
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Beta-catenin Binding Hydrolase Activity Protein Kinase Binding Gamma-catenin Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity Identical Protein Binding Cadherin Binding
	Biological Process	Protein Dephosphorylation Cell Adhesion Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Negative Regulation Of Keratinocyte Proliferation Cell Migration Negative Regulation Of Cell Migration Neuron Projection Development Protein Localization To Cell Surface Cellular Response To Reactive Oxygen Species Cellular Response To UV Negative Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Focal Adhesion Assembly	Negative Regulation Of Endothelial Cell Proliferation Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Response To Xenobiotic Stimulus Negative Regulation Of Endothelial Cell Migration Positive Regulation Of D-glucose Transmembrane Transport Negative Regulation Of D-glucose Transmembrane Transport Retina Layer Formation Negative Regulation Of Angiogenesis Negative Regulation Of Cell Migration Neuron Projection Development Retinal Ganglion Cell Axon Guidance D-glucose Transmembrane Transport
Pathways		EGFR downregulation
Drugs
Diseases
GWAS		Adiponectin levels ( 33562295) Allergic disease (asthma, hay fever or eczema) ( 29083406) Arterial stiffness (brachial-femoral pulse wave velocity) ( 32790701) Asthma ( 31959851 31619474 31361310 30929738 32296059 34103634) Asthma (childhood onset) ( 30929738) Celiac disease ( 30572963 22057235 20190752) Crohn's disease ( 28067908) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Hodgkin's lymphoma ( 29196614) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Menarche (age at onset) ( 25231870) Metabolite levels ( 23823483) Multiple sclerosis ( 21833088) Nodular sclerosis Hodgkin lymphoma ( 29196614) Reaction time ( 29844566) Uterine fibroid size (maximum volume) ( 30196971) Waist circumference ( 28552196)	Adult body size ( 32376654) Benign childhood epilepsy with centro-temporal spikes ( 32580138) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Dialysis-related mortality ( 21546767) Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer ( 28429243) Glucose homeostasis traits ( 25524916) Hippocampal volume ( 29860282) Huntington's disease progression ( 28642124) Iris heterochromicity ( 30895295) Lateral ventricle temporal horn volume ( 31530798) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828) Recurrence of mild malaria attacks ( 31667592) Response to methotrexate in rheumatoid arthritis ( 24583629) Sitting height ratio ( 25865494)
Interacting Genes		9 interacting genes: CSNK2B CTNNB1 GADD45A GADD45G JUP PSMD11 PTPRM RIPK4 TK1	12 interacting genes: BCCIP CDH1 CNKSR1 CTNNB1 CTNND1 IQGAP1 PCSK5 PPFIBP1 PTPRA PTPRK PTPRS RACK1
Entrez ID		5796	5797
HPRD ID		03968	01479
Ensembl ID		ENSG00000152894	ENSG00000173482
Uniprot IDs		B4DHC3 Q15262 Q59EZ1 Q86WJ2	P28827
PDB IDs		2C7S 8A1F	1RPM 2C9A 2V5Y 8A16 8A17
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Endothelial Cell Migration Catenin-TCF7L2 Complex Regulation Of Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Cellular Response To Indole-3-methanol Skin Development Response To Indole-3-methanol Negative Regulation Of Cell Migration Endothelial Tube Morphogenesis Regulation Of Vasculature Development Alpha-catenin Binding Regulation Of Angiogenesis Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Regulation Of Blood Vessel Endothelial Cell Migration Ficolin-1-rich Granule Lumen Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Positive Regulation Of P38MAPK Cascade Catenin Complex Adherens Junction Response To Mechanical Stimulus Cell-cell Junction Regulation Of P38MAPK Cascade Detection Of Mechanical Stimulus Protein-DNA Complex Nuclear Receptor Binding Intercalated Disc Wnt Signaling Pathway Cytoplasm Glial Cell Fate Determination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Cadherin Binding Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Gamma-catenin-TCF7L2 Complex Morphogenesis Of An Epithelium Positive Regulation Of Signal Transduction Regulation Of Anatomical Structure Morphogenesis Regulation Of Cell Migration Positive Regulation Of Cell Communication Positive Regulation Of Signaling Tissue Morphogenesis Mesenchymal Stem Cell Differentiation Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Beta-catenin-ICAT Complex Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Renal Outer Medulla Development	Cadherin Binding Cell-cell Junction Catenin Complex Cell-cell Adhesion Mediated By Cadherin Cellular Response To Indole-3-methanol Anchoring Junction Response To Indole-3-methanol Cell Cortex Adherens Junction Cell Junction Organization Regulation Of Blood Vessel Branching Lateral Plasma Membrane Cell Adhesion Flotillin Complex Synapse Organization Gamma-catenin Binding Protein Phosphatase Binding Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Negative Regulation Of Neurogenesis Phosphoprotein Phosphatase Activity Negative Regulation Of Nervous System Development Regulation Of Cell Growth Plasma Membrane Negative Regulation Of Cell Growth Apical Junction Complex Negative Regulation Of Axon Extension Focal Adhesion Protein Localization To Cell Surface Regulation Of Anatomical Structure Morphogenesis Cell-cell Adhesion Mediator Activity Regulation Of Multicellular Organismal Development Extracellular Exosome Cellular Response To Oxygen-containing Compound Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Midbody Molecular Adaptor Activity Cell Migration Cell-cell Adhesion Cell Junction Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Intercalated Disc Negative Regulation Of Growth Gastrulation Negative Regulation Of Axonogenesis Adherens Junction Organization Cell Motility Regulation Of Morphogenesis Of A Branching Structure Glial Cell Fate Determination Phosphatase Binding
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