PTPRK and RIPK4

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		PTPRK	RIPK4
Description		protein tyrosine phosphatase receptor type K	receptor interacting serine/threonine kinase 4
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Adherens Junction Cell Surface Membrane Cell Junction Leading Edge Membrane Anchoring Junction	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Beta-catenin Binding Hydrolase Activity Protein Kinase Binding Gamma-catenin Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Protein Dephosphorylation Cell Adhesion Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Negative Regulation Of Keratinocyte Proliferation Cell Migration Negative Regulation Of Cell Migration Neuron Projection Development Protein Localization To Cell Surface Cellular Response To Reactive Oxygen Species Cellular Response To UV Negative Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Focal Adhesion Assembly	Morphogenesis Of An Epithelium Skin Development Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways		EGFR downregulation
Drugs
Diseases
GWAS		Adiponectin levels ( 33562295) Allergic disease (asthma, hay fever or eczema) ( 29083406) Arterial stiffness (brachial-femoral pulse wave velocity) ( 32790701) Asthma ( 31959851 31619474 31361310 30929738 32296059 34103634) Asthma (childhood onset) ( 30929738) Celiac disease ( 30572963 22057235 20190752) Crohn's disease ( 28067908) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Hodgkin's lymphoma ( 29196614) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Menarche (age at onset) ( 25231870) Metabolite levels ( 23823483) Multiple sclerosis ( 21833088) Nodular sclerosis Hodgkin lymphoma ( 29196614) Reaction time ( 29844566) Uterine fibroid size (maximum volume) ( 30196971) Waist circumference ( 28552196)	Femur bone mineral density x serum urate levels interaction ( 34046847) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		9 interacting genes: CSNK2B CTNNB1 GADD45A GADD45G JUP PSMD11 PTPRM RIPK4 TK1	38 interacting genes: ANK2 ANK3 ANKRD6 ASB3 BIRC2 BIRC3 BTRC CARS2 CLTC CTBP1 FBXW11 GPSM3 HSPA5 KPNA1 LINC01537 MACF1 MAGI2 MIB1 MICU1 MTPN MYO1E NAPA PADI2 PREPL PRKCB PRKCD PTPRK RPL13 SPAG8 SPAST STAM TNPO2 TRAF7 UBE4B VCP VWC2L WDR19 XIAP
Entrez ID		5796	54101
HPRD ID		03968	10419
Ensembl ID		ENSG00000152894	ENSG00000183421
Uniprot IDs		B4DHC3 Q15262 Q59EZ1 Q86WJ2	Q96T11 Q9H4D1
PDB IDs		2C7S 8A1F
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Endothelial Cell Migration Catenin-TCF7L2 Complex Regulation Of Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Cellular Response To Indole-3-methanol Skin Development Response To Indole-3-methanol Negative Regulation Of Cell Migration Endothelial Tube Morphogenesis Regulation Of Vasculature Development Alpha-catenin Binding Regulation Of Angiogenesis Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Regulation Of Blood Vessel Endothelial Cell Migration Ficolin-1-rich Granule Lumen Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Positive Regulation Of P38MAPK Cascade Catenin Complex Adherens Junction Response To Mechanical Stimulus Cell-cell Junction Regulation Of P38MAPK Cascade Detection Of Mechanical Stimulus Protein-DNA Complex Nuclear Receptor Binding Intercalated Disc Wnt Signaling Pathway Cytoplasm Glial Cell Fate Determination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Cadherin Binding Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Gamma-catenin-TCF7L2 Complex Morphogenesis Of An Epithelium Positive Regulation Of Signal Transduction Regulation Of Anatomical Structure Morphogenesis Regulation Of Cell Migration Positive Regulation Of Cell Communication Positive Regulation Of Signaling Tissue Morphogenesis Mesenchymal Stem Cell Differentiation Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Beta-catenin-ICAT Complex Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Renal Outer Medulla Development	Cytoplasm Canonical NF-kappaB Signal Transduction Cellular Localization Signal Transduction Vesicle-mediated Transport Intracellular Protein Localization Protein Transport Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Protein Ubiquitination Post-translational Protein Modification Positive Regulation Of Post-translational Protein Modification Intracellular Signaling Cassette Establishment Of Protein Localization Ubiquitin Protein Ligase Activity Mitotic Spindle Disassembly Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Protein Modification Process Protein Kinase C Signaling Golgi Vesicle Transport Protein Polyubiquitination Intracellular Transport Regulation Of Cell Communication Non-canonical NF-kappaB Signal Transduction Cell Surface Receptor Signaling Pathway Protein Localization To Membrane Positive Regulation Of Protein Metabolic Process Protein Metabolic Process Golgi To Plasma Membrane Protein Transport Regulation Of Canonical NF-kappaB Signal Transduction Intracellular Signal Transduction Regulation Of Wnt Signaling Pathway Establishment Of Localization In Cell Positive Regulation Of Protein Ubiquitination Channel Activator Activity Proteolysis Involved In Protein Catabolic Process Protein Localization To Cell Periphery Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Intracellular Protein Transport Negative Regulation Of Signal Transduction Regulation Of Post-translational Protein Modification Cytosol Ubiquitin-dependent Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Modification-dependent Protein Catabolic Process Cytoskeleton Positive Regulation Of Membrane Potential Establishment Of Protein Localization To Plasma Membrane
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