DAPK1 and YWHAB

Number of citations of the paper that reports this interaction (PMID 12911633)
9

Data Source:
HPRD (in vitro, in vivo)

		DAPK1	YWHAB
Gene Name		death-associated protein kinase 1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Actin Cytoskeleton	Nucleus Cytoplasm Cytosol Focal Adhesion Membrane Transcriptional Repressor Complex Cytoplasmic Vesicle Membrane Melanosome Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Syntaxin-1 Binding Identical Protein Binding	Transcription Corepressor Activity Protein Binding Protein C-terminus Binding Enzyme Binding Protein Domain Specific Binding Protein Complex Binding Histone Deacetylase Binding Phosphoserine Binding Phosphoprotein Binding
	Biological Process	Protein Phosphorylation Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Autophagy Negative Regulation Of Translation Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Autophosphorylation Cellular Response To Interferon-gamma Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity	MAPK Cascade Activation Of MAPKK Activity Protein Targeting Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Axon Guidance Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Gene Expression Negative Regulation Of Protein Dephosphorylation Hippo Signaling Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Innate Immune Response Negative Regulation Of Transcription, DNA-templated Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Cytoplasmic Sequestering Of Protein Protein Heterooligomerization Membrane Organization Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways		Programmed Cell Death Role of DCC in regulating apoptosis Extrinsic Pathway	Signaling by GPCR Signaling by FGFR in disease Activation of BH3-only proteins MEK activation FCERI mediated MAPK activation Signaling by EGFRvIII in Cancer SHC1 events in ERBB2 signaling Signaling by SCF-KIT DAP12 signaling Rap1 signalling Gastrin-CREB signalling pathway via PKC and MAPK SOS-mediated signalling SHC-mediated signalling Signaling by PDGF Regulation of mRNA stability by proteins that bind AU-rich elements DAP12 interactions SHC-related events triggered by IGF1R GRB2 events in EGFR signaling Signaling by ERBB4 Signaling by ERBB2 Activation of BAD and translocation to mitochondria Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Signaling by VEGF Signalling to RAS Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Interleukin-2 signaling Frs2-mediated activation Adaptive Immune System Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Axon guidance IRS-mediated signalling Translocation of GLUT4 to the plasma membrane IGF1R signaling cascade VEGFA-VEGFR2 Pathway IRS-related events triggered by IGF1R GRB2 events in ERBB2 signaling VEGFR2 mediated cell proliferation RAF phosphorylates MEK Downstream signaling of activated FGFR Programmed Cell Death NCAM signaling for neurite out-growth RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Intrinsic Pathway for Apoptosis Butyrate Response Factor 1 (BRF1) destabilizes mRNA Innate Immune System Signaling by Insulin receptor Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling SHC-mediated signalling Cytokine Signaling in Immune system IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer Tristetraprolin (TTP) destabilizes mRNA NGF signalling via TRKA from the plasma membrane SHC-related events Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR ARMS-mediated activation Signaling by Hippo RAF activation SHC1 events in EGFR signaling IRS-mediated signalling FRS2-mediated cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Drugs		5,6-Dihydro-Benzo[H]Cinnolin-3-Ylamine Phosphoaminophosphonic Acid-Adenylate Ester 6-(3-AMINOPROPYL)-4,9-DIMETHYLPYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE
Diseases
GWAS		Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Response to gemcitabine in pancreatic cancer ( 22293537)
Protein-Protein Interactions		16 interactors: CALM1 FADD IKBKG LNX1 MAPK1 MAPK3 MDM2 MIB1 MYL12B STX1A TNFRSF1A TRADD UNC5A UNC5B UNC5C YWHAB	137 interactors: ABL1 ADAM22 AKAP13 ALS2 APP ATP5A1 BAD BAX BCL2L11 BCR BID BRAF C1QBP CAMK2A CAMK2B CBL CDC25A CDC25B CDC25C CDK11B CDK14 CDKN1B CHAF1A CRTC2 CSNK2A1 DAPK1 DHX15 DYRK1A EDC3 EPB41 EPB41L1 EPB41L3 EXO1 FER FRMD6 GAPVD1 GEM HDAC5 HES1 HIST1H3A HSP90AB1 HSPA1A HSPA1B HSPA5 IGF1R IKBKB ING1 INSR IRS1 IRS2 ITGB1 ITGB4 KCNK15 KCNK3 KCNK9 KIAA0930 KIF1C KIF23 KIF5B KLC1 KRT18 LARP1 LYST MAP3K3 MAPK7 MAPT MARK2 MARK4 MDM4 MICALL1 MINK1 MLLT4 MLXIP MPRIP MST1R OSBPL3 PARD3 PARD6B PDCL2 PDE3B PI4KB PIK3R2 PIK3R4 PRKCD PRKCG PRKCZ PRPF6 PTPN3 RABGEF1 RACGAP1 RADIL RAF1 RAI14 RALGPS2 RASGRF1 RGS3 RGS7 RIN1 RIOK1 RMDN3 RNPS1 RPS6KA1 SAMSN1 SKP2 SLC4A7 SLC8A1 SLC8A2 SLC8A3 SLC9A1 SNCA SNRNP200 SON SRC SRPK2 SRRM2 SRSF10 SRSF3 STK38 STK38L TESK1 TESK2 TH TJP2 TNFAIP3 TPD52L1 TSC1 TSC2 TUBB UBC UCP2 UCP3 WDR77 WEE1 YWHAE YWHAG ZFP36 ZFP36L1
Entrez ID		1612	7529
HPRD ID		02902	03184
Ensembl ID		ENSG00000196730	ENSG00000166913
Uniprot IDs		P53355 Q59H88	P31946
PDB IDs		1IG1 1JKK 1JKL 1JKS 1JKT 1P4F 1WVW 1WVX 1WVY 1YR5 2W4J 2W4K 2X0G 2XUU 2XZS 2Y0A 2Y4P 2Y4V 2YAK 3DFC 3DGK 3EH9 3EHA 3F5G 3F5U 3GU4 3GU5 3GU6 3GU7 3GU8 3GUB 3ZXT 4B4L	2BQ0 2C23 4DNK
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Response To External Stimulus Axon Guidance Anterior/posterior Axon Guidance Fc-epsilon Receptor Signaling Pathway Signaling Cell Communication Positive Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Axonogenesis Cell Surface Receptor Signaling Pathway Axon Development Signal Transduction Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Epidermal Growth Factor Receptor Signaling Pathway Chemotaxis Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Cell Death TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Apoptotic Process Neuron Projection Morphogenesis Immune Response-regulating Cell Surface Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Cell Death Cell Morphogenesis Involved In Differentiation Toll-like Receptor 4 Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Regulation Of Intracellular Transport Neurotrophin Signaling Pathway Regulation Of Signaling Innate Immune Response Regulation Of Intracellular Signal Transduction Neuron Projection Development Positive Regulation Of Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Projection Morphogenesis Cell Part Morphogenesis	Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Intracellular Signal Transduction Regulation Of Signaling Regulation Of Phosphorylation Regulation Of Cell Death Cellular Response To Organic Substance Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Cell Communication Regulation Of Apoptotic Process Regulation Of Signal Transduction Regulation Of Catalytic Activity Regulation Of Protein Phosphorylation Response To Organic Substance Cellular Response To Stimulus Response To Stress Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Metabolic Process Signaling Protein Phosphorylation Cell Cycle Response To Growth Factor Response To Stimulus Regulation Of Cell Cycle Regulation Of Protein Kinase Activity Developmental Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Negative Regulation Of Programmed Cell Death Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cellular Process Neurotrophin Signaling Pathway Innate Immune Response Intracellular Transport Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Cell Death Cellular Response To Organonitrogen Compound Signal Transduction Cellular Response To Growth Factor Stimulus Phosphorylation Cellular Localization Cellular Response To Insulin Stimulus Anatomical Structure Development Regulation Of Intracellular Signal Transduction Response To Organonitrogen Compound Immune System Process Regulation Of Metabolic Process
Tagcloud ?		aberrant aifm2 aml array backgroundpediatric bgs bisulfite comprises conclusionin dcc details dysregulated ebf3 firstly glioblastoma hypermethylated idiopathic itp kaplan leukemogenesis meier methodstwelve methylated msp nbm patterning pediatric purpura thrombocytopenic	3gamma actb atp1a1 atp1a2 atp1a3 belong confirms constituted gb glioblastoma highlights hsp90aa1 hspa8 icpl identity isolate lethal network outside peri pump quantification redundant researches trails trying tumoral ywhag ywhaz
Tagcloud (Difference) ?		aberrant aifm2 aml array backgroundpediatric bgs bisulfite comprises conclusionin dcc details dysregulated ebf3 firstly hypermethylated idiopathic itp kaplan leukemogenesis meier methodstwelve methylated msp nbm patterning pediatric purpura thrombocytopenic	3gamma actb atp1a1 atp1a2 atp1a3 belong confirms constituted gb highlights hsp90aa1 hspa8 icpl identity isolate lethal network outside peri pump quantification redundant researches trails trying tumoral ywhag ywhaz
Tagcloud (Intersection) ?		glioblastoma