DAPK1 and PRR16

Number of citations of the paper that reports this interaction (PubMedID 29513927)
77

Data Source:
BioGRID (pull down)

		DAPK1	PRR16
Description		death associated protein kinase 1	proline rich 16
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton Plasma Membrane Postsynaptic Density Actin Cytoskeleton Organelle Glutamatergic Synapse DAPK1-calmodulin Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding GTP Binding Kinase Activity Transferase Activity Syntaxin-1 Binding Identical Protein Binding Protein Serine Kinase Activity	Protein Binding
	Biological Process	Defense Response To Tumor Cell Regulation Of Response To Tumor Cell Regulation Of Translation Protein Phosphorylation Apoptotic Process Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Autophagy Positive Regulation Of Autophagy Negative Regulation Of Translation Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Protein Autophosphorylation Cellular Response To Type II Interferon Cellular Response To Hydroperoxide Apoptotic Signaling Pathway Positive Regulation Of Autophagic Cell Death Regulation Of NMDA Receptor Activity	Positive Regulation Of Translation Positive Regulation Of Cell Size
Pathways		Caspase activation via Dependence Receptors in the absence of ligand
Drugs		5,6-Dihydro-Benzo[H]Cinnolin-3-Ylamine Phosphoaminophosphonic Acid-Adenylate Ester 6-(3-AMINOPROPYL)-4,9-DIMETHYLPYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE Fostamatinib
Diseases		Bladder cancer
GWAS		Blood pressure ( 24954895) Cognitive function ( 24684796) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Height ( 31562340) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Night sleep phenotypes ( 27126917) Ovarian cancer ( 30557369) Post bronchodilator FEV1/FVC ratio ( 26634245) Response to gemcitabine in pancreatic cancer ( 22293537)	Adult body size ( 32376654) Age-related cognitive decline (global cognition) (slope of z-scores) ( 30954325) Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Body mass index (change over time) ( 25133637) Bronchopulmonary dysplasia ( 23897914) Cognitive decline rate in late mild cognitive impairment ( 26252872) Immune reponse to smallpox (secreted IL-12p40) ( 22610502) Loneliness (linear analysis) ( 27629369) Numerical cognitive ability ( 31620175) Pulse pressure ( 30224653) Verbal cognitive ability ( 31620175) Verbal declarative memory ( 25648963) Weight ( 28552196)
Interacting Genes		109 interacting genes: ABL1 ABLIM1 AHDC1 APEX2 ARRDC1 ARRDC1-AS1 ATF6 BAG2 BAIAP2 C11orf65 CALM1 CAPRIN1 CBLB CCDC149 CDC42EP3 CDC42SE1 CMTM4 CNTROB DENND1C DTWD1 DUS1L DUX3 EIF4ENIF1 EPHA1 FADD FAM107A FBXL14 FBXW11 FIBP GASK1B GTF2F1 HYCC2 IKBKG JHY LIMA1 LIMS1 LINC02875 LMF2 LNX1 LOXL2 MAPK1 MAPK3 MCM10 MDM2 MIB1 MRGBP MTHFD2 MYL12B NCBP3 NECAB1 NECAP1 NR3C1 ORMDL2 PAK6 PAPSS2 PCP4 PHKG2 PIM1 PIM2 POLR2M PPP1R14A PPP2R1A PPP2R2D PPP2R5A PRKAG2 PRR16 PRRC2B PWP1 RAPGEF3 RASGRP2 RCHY1 RFC5 RHBDD1 RPAP3 RPL41 SARNP SCEL SCRN3 SCYL1 SGK2 SH2D2A SLAIN2 SNRPA SNURF SNX9 SPATS2 SPRR2G SRSF10 STARD3 STUB1 STX1A TAS2R60 TBC1D22B TNFRSF1A TPD52L1 TRADD TRAPPC2 TTC27 TUBB4B UNC5A UNC5B UNC5C VGLL4 VN1R1 WWTR1 YWHAB ZAP70 ZMAT4 ZMYM5	11 interacting genes: ABI2 APP DAPK1 DLG4 NCK2 NEDD4 NEDD4L NOD2 PPP1CA PPP1CC SMURF1
Entrez ID		1612	51334
HPRD ID		02902	14239
Ensembl ID		ENSG00000196730	ENSG00000184838
Uniprot IDs		B4DHI4 P53355 Q59H88	Q569H4
PDB IDs		1IG1 1JKK 1JKL 1JKS 1JKT 1P4F 1WVW 1WVX 1WVY 1YR5 2W4J 2W4K 2X0G 2XUU 2XZS 2Y0A 2Y4P 2Y4V 2YAK 3DFC 3DGK 3EH9 3EHA 3F5G 3F5U 3GU4 3GU5 3GU6 3GU7 3GU8 3GUB 3ZXT 4B4L 4PF4 4TL0 4TXC 4UV0 4YO4 4YPD 5AUT 5AUU 5AUV 5AUW 5AUX 5AUY 5AUZ 5AV0 5AV1 5AV2 5AV3 5AV4 6AAR 6FHA 6FHB 6GY5 6IN4 6QMO 6QN4 7CCU 7CCV 7CCW 8IE5 8IE6 8IE7 8IE8 8ODZ 8OE0 8OE4 8PB1 9DUB 9DUE 9INV 9INW 9INX 9MIU
Enriched GO Terms of Interacting Partners?		Cytosol Netrin Receptor Activity Phosphotyrosine Residue Binding Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Catabolic Process Positive Regulation Of Proteolysis Anterior/posterior Axon Guidance Netrin-activated Signaling Pathway Positive Regulation Of Cytoskeleton Organization Bergmann Glial Cell Differentiation Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Astrocyte Differentiation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Interleukin-34-mediated Signaling Pathway Regulation Of Protein Stability Protein Phosphatase Type 2A Complex Apoptotic Process Regulation Of Proteolysis Regulation Of Protein Metabolic Process Regulation Of Golgi Inheritance Tumor Necrosis Factor Receptor Superfamily Complex Thymus Development Programmed Cell Death Cell Death Cytoplasm Positive Regulation Of Organelle Organization Protein Kinase Activity Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation ERBB2 Signaling Pathway Positive Regulation Of Cellular Component Biogenesis Kinase Binding Endocytosis Regulation Of Cytoskeleton Organization Receptor Serine/threonine Kinase Binding Protein Domain Specific Binding Regulation Of Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Actin Filament Bundle Assembly T Cell Receptor Signaling Pathway Lymphocyte Homeostasis Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Death-inducing Signaling Complex	Dendritic Spine Receptor Catabolic Process Positive Regulation Of Catabolic Process Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cell Projection Organization Protein Modification Process Protein-containing Complex Binding Positive Regulation Of Cellular Component Organization Receptor Metabolic Process NMDA Selective Glutamate Receptor Signaling Pathway Negative Regulation Of Potassium Ion Export Across Plasma Membrane Positive Regulation Of Protein Metabolic Process PTW/PP1 Phosphatase Complex Sodium Channel Inhibitor Activity Presynapse Postsynapse Potassium Channel Inhibitor Activity Regulation Of Translational Initiation In Response To Stress Glutamatergic Synapse Regulation Of Potassium Ion Export Across Plasma Membrane Protein Polyubiquitination Acetylcholine Receptor Binding Regulation Of Synapse Organization Cell Projection Organization Negative Regulation Of Sodium Ion Transport Regulation Of Cellular Component Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Response To Light Stimulus Response To Metal Ion Response To Lead Ion Transition Metal Ion Binding Positive Regulation Of Dendrite Extension Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Translation In Response To Stress Cytoskeletal Anchor Activity Macromolecule Metabolic Process Entrainment Of Circadian Clock By Photoperiod Positive Regulation Of Apoptotic Signaling Pathway Protein Phosphatase 1 Binding Regulation Of Translation Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Neuron Projection Development Photoperiodism Entrainment Of Circadian Clock Ionotropic Glutamate Receptor Signaling Pathway Plasma Membrane Bounded Cell Projection Organization Regulation Of Membrane Potential Positive Regulation Of Supramolecular Fiber Organization Response To Radiation
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