AHCYL1 and ZNF165

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AHCYL1	ZNF165
Description		adenosylhomocysteinase like 1	zinc finger protein 165
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Apical Plasma Membrane Intracellular Membrane-bounded Organelle Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Extracellular Exosome	Nucleus
	Molecular Function	RNA Binding Adenosylhomocysteinase Activity Protein Binding Enzyme Regulator Activity Identical Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Protein Export From Nucleus One-carbon Metabolic Process Apoptotic Process Positive Regulation Of Sodium Ion Transport Regulation Of MRNA 3'-end Processing Regulation Of Monoatomic Ion Transmembrane Transporter Activity S-adenosylmethionine Cycle Angiotensin-activated Signaling Pathway Epithelial Fluid Transport Regulation Of Monoatomic Anion Transport Response To Calcium Ion Mitochondrion-endoplasmic Reticulum Membrane Tethering	Regulation Of Transcription By RNA Polymerase II
Pathways		PLC beta mediated events DAG and IP3 signaling Role of phospholipids in phagocytosis FCERI mediated Ca+2 mobilization Regulation of insulin secretion VEGFR2 mediated cell proliferation Ion homeostasis Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases
GWAS		Height ( 31562340)	Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 33097823) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Estimated glomerular filtration rate ( 31451708) Fish- and plant-related diet ( 32066663) HDL cholesterol levels ( 32203549) Hepcidin/ferritin ratio ( 27846281) LDL cholesterol levels ( 32203549) Lung function (FEV1/FVC) ( 30175238) Moderate to vigorous physical activity levels ( 29899525) Refractive error ( 32231278) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Squamous cell lung carcinoma ( 28604730) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		25 interacting genes: BID BTG3 CDKN2C CFTR DACH1 GEM HBQ1 HGS HSPA6 ITPR1 LRRK2 MEOX2 MFHAS1 PLEKHG5 PPL PRDM6 PSMD9 RNF6 SLC23A1 SOX30 SRPK1 SRPK2 SUMO2 UACA ZNF165	46 interacting genes: AHCYL1 CARD10 CCDC125 CCDC85B CEP70 DVL2 DVL3 ELOA2 EMD EWSR1 FAM124A GOLGA6L9 GPATCH2L HOMEZ IL16 KAT7 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP2-3 KRTAP2-4 KRTAP4-12 MAB21L3 MID2 NTAQ1 PDLIM7 PICK1 PLEKHF2 PPL RNPS1 SCAND1 SUV39H1 TRIM41 YJU2B ZKSCAN8 ZNF24 ZNF250 ZNF263 ZNF417 ZNF446 ZNF572 ZNF668 ZNF774 ZNF837
Entrez ID		10768	7718
HPRD ID		07613	02903
Ensembl ID		ENSG00000168710	ENSG00000197279
Uniprot IDs		A0A024R0A8 O43865	P49910 Q53Z40
PDB IDs		3MTG
Enriched GO Terms of Interacting Partners?			Keratin Filament Intermediate Filament Regulation Of RNA Metabolic Process Zinc Ion Binding Identical Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Neuron Projection Arborization Protein Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Neuron Projection Arborization
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