AHCYL1 and PPL

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		AHCYL1	PPL
Gene Name		adenosylhomocysteinase-like 1	periplakin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Cytosol Extracellular Vesicular Exosome	Nucleus Mitochondrion Cytoskeleton Plasma Membrane Desmosome Extracellular Vesicular Exosome
	Molecular Function	Adenosylhomocysteinase Activity Protein Binding	Structural Constituent Of Cytoskeleton Protein Binding
	Biological Process	MRNA Polyadenylation Protein Export From Nucleus One-carbon Metabolic Process Biological_process Positive Regulation Of Sodium Ion Transport Regulation Of MRNA 3'-end Processing Regulation Of Ion Transmembrane Transporter Activity S-adenosylmethionine Cycle Regulation Of Anion Transport	Keratinization
Pathways
Drugs
Diseases
GWAS			Lung cancer-asbestos exposure interaction ( 22637743) Metabolite levels (HVA/MHPG ratio) ( 23319000)
Protein-Protein Interactions		14 interactors: BID CDKN2C DACH1 GEM HGS ITPR1 MEOX2 PPL PSMD9 SLC23A1 SOX30 SRPK1 SRPK2 ZNF165	22 interactors: AHCYL1 AKT1 ALAS1 CASP6 CEP57L1 COL17A1 EVPL ITSN1 KAZN KRT8 OPRM1 PPHLN1 RAB3IP RALBP1 SKIL TRAF2 TRIM27 TSC22D4 UBC USP7 VIM ZSCAN1
Entrez ID		10768	5493
HPRD ID		07613	04187
Ensembl ID		ENSG00000168710	ENSG00000118898
Uniprot IDs		O43865	O60437
PDB IDs		3MTG
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Regulation Of Metabolic Process Intracellular Signal Transduction Nuclear Speck Organization Transepithelial L-ascorbic Acid Transport Neuron Death Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Negative Regulation Of Viral Process Developmental Process Regulation Of Cell Proliferation L-ascorbic Acid Transport Molecular Hydrogen Transport Regulation Of MRNA Processing Signal Transduction In Response To DNA Damage Regulation Of RNA Splicing Regulation Of Cell Cycle Gene Expression RNA Polymerase II Transcriptional Preinitiation Complex Assembly Proteasome Regulatory Particle Assembly Multicellular Organismal Development Nucleus Organization Voluntary Musculoskeletal Movement Dehydroascorbic Acid Transport Regulation Of Cellular Localization Cell Death Death Regulation Of Gene Expression Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Cellular Nitrogen Compound Metabolic Process Nucleobase Transport Somite Specification Regulation Of Viral Process G1/S Transition Of Mitotic Cell Cycle Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Glial Cell Apoptotic Process Negative Regulation Of Calcium-mediated Signaling Intrinsic Apoptotic Signaling Pathway Immune Response Cellular Macromolecular Complex Assembly Negative Regulation Of Transcription By Competitive Promoter Binding Sperm Chromatin Condensation Positive Regulation Of Protein Homooligomerization Regulation Of Secretion Immune System Process	Epithelial Cell Differentiation Epithelium Development Protein Trimerization Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Keratinization Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Execution Phase Of Apoptosis Keratinocyte Differentiation Tissue Development Epidermis Development Regulation Of Intracellular Signal Transduction Protein Homotrimerization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Growth Factor Response To Food Positive Regulation Of Cell Death Apoptotic Signaling Pathway Glycogen Biosynthetic Process Developmental Process Epidermal Cell Differentiation Response To Cytokine Tumor Necrosis Factor-mediated Signaling Pathway Cell Differentiation Involved In Embryonic Placenta Development Cell Differentiation Anatomical Structure Development Protein K63-linked Ubiquitination Lens Fiber Cell Differentiation Positive Regulation Of Sodium Ion Transport Protein Polyubiquitination Regulation Of Ion Transmembrane Transport Cellular Polysaccharide Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Polysaccharide Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Signal Transduction Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Catalytic Activity Regulation Of Phosphorylation Negative Regulation Of Neuron Death Positive Regulation Of Phosphorylation Negative Regulation Of Ion Transmembrane Transport Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Organic Substance
Tagcloud ?		abnormality accession attempt csf1 elicit exon exons fused fusion giant karyotypic kb nos nt p11 pathogenetic q21 replaced replacement s100a10 sole stop tag tenosynovial theme transcript tsgct untranslated utr	32p aug carboxyl codons dephosphorylation detergents digestion disposition doublet duck embo envelope ganem hepadnavirus hepadnaviruses immunoblots imply labelling morphogenesis myristic myristylation ostapchuk p35 phosphatases s1 s2 topological virion yielding
Tagcloud (Difference) ?		abnormality accession attempt csf1 elicit exon exons fused fusion giant karyotypic kb nos nt p11 pathogenetic q21 replaced replacement s100a10 sole stop tag tenosynovial theme transcript tsgct untranslated utr	32p aug carboxyl codons dephosphorylation detergents digestion disposition doublet duck embo envelope ganem hepadnavirus hepadnaviruses immunoblots imply labelling morphogenesis myristic myristylation ostapchuk p35 phosphatases s1 s2 topological virion yielding
Tagcloud (Intersection) ?