AHCYL1 and PLEKHG5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AHCYL1	PLEKHG5
Description		adenosylhomocysteinase like 1	pleckstrin homology and RhoGEF domain containing G5
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Apical Plasma Membrane Intracellular Membrane-bounded Organelle Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Extracellular Exosome	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Membrane Lamellipodium Endocytic Vesicle Axon Cell Projection Perinuclear Region Of Cytoplasm Anchoring Junction
	Molecular Function	RNA Binding Adenosylhomocysteinase Activity Protein Binding Enzyme Regulator Activity Identical Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Protein Export From Nucleus One-carbon Metabolic Process Apoptotic Process Positive Regulation Of Sodium Ion Transport Regulation Of MRNA 3'-end Processing Regulation Of Monoatomic Ion Transmembrane Transporter Activity S-adenosylmethionine Cycle Angiotensin-activated Signaling Pathway Epithelial Fluid Transport Regulation Of Monoatomic Anion Transport Response To Calcium Ion Mitochondrion-endoplasmic Reticulum Membrane Tethering	Rho Protein Signal Transduction Endothelial Cell Chemotaxis Positive Regulation Of Canonical NF-kappaB Signal Transduction Endothelial Cell Migration Regulation Of Small GTPase Mediated Signal Transduction
Pathways		PLC beta mediated events DAG and IP3 signaling Role of phospholipids in phagocytosis FCERI mediated Ca+2 mobilization Regulation of insulin secretion VEGFR2 mediated cell proliferation Ion homeostasis Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RND3 GTPase cycle RND1 GTPase cycle
Drugs
Diseases			Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS		Height ( 31562340)	Multiple sclerosis ( 24076602) QT interval ( 19305408)
Interacting Genes		25 interacting genes: BID BTG3 CDKN2C CFTR DACH1 GEM HBQ1 HGS HSPA6 ITPR1 LRRK2 MEOX2 MFHAS1 PLEKHG5 PPL PRDM6 PSMD9 RNF6 SLC23A1 SOX30 SRPK1 SRPK2 SUMO2 UACA ZNF165	1 interacting genes: AHCYL1
Entrez ID		10768	57449
HPRD ID		07613	11104
Ensembl ID		ENSG00000168710	ENSG00000171680
Uniprot IDs		A0A024R0A8 O43865	A0A804EMX3 O94827
PDB IDs		3MTG
Enriched GO Terms of Interacting Partners?			S-adenosylmethionine Cycle Adenosylhomocysteinase Activity Mitochondrion-endoplasmic Reticulum Membrane Tethering Regulation Of Monoatomic Anion Transport Regulation Of MRNA 3'-end Processing S-adenosylmethionine Metabolic Process Epithelial Fluid Transport Angiotensin-activated Signaling Pathway Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site One-carbon Metabolic Process Fluid Transport Protein Export From Nucleus Positive Regulation Of Sodium Ion Transport Enzyme Regulator Activity Transepithelial Transport Regulation Of Sodium Ion Transport Regulation Of Transmembrane Transporter Activity Membrane Docking Regulation Of Monoatomic Ion Transmembrane Transporter Activity Organelle Localization By Membrane Tethering Nuclear Export Regulation Of MRNA Processing Response To Calcium Ion Intracellular Membrane-bounded Organelle Positive Regulation Of Monoatomic Ion Transport Nuclear Transport Nucleocytoplasmic Transport Sulfur Compound Metabolic Process
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