SYT7

Description		synaptotagmin 7
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GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Peroxisome Peroxisomal Membrane Cytosol Plasma Membrane Synaptic Vesicle Endomembrane System Membrane Axon Transport Vesicle Membrane Phagocytic Vesicle Membrane Synaptic Vesicle Membrane Dense Core Granule Cytoplasmic Vesicle Early Phagosome Presynaptic Membrane Cell Projection Synapse Extracellular Exosome Hippocampal Mossy Fiber To CA3 Synapse Secretory Vesicle
	Molecular Function	SNARE Binding Calcium Ion Binding Protein Binding Calmodulin Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Syntaxin Binding Clathrin Binding Metal Ion Binding Calcium Ion Sensor Activity
	Biological Process	Plasma Membrane Repair Exocytosis Vesicle Fusion Phagocytosis Vesicle-mediated Transport Calcium-ion Regulated Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Endocytosis Synaptic Vesicle Recycling Positive Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Bone Remodeling Calcium Ion-regulated Exocytosis Of Neurotransmitter Regulation Of Phagocytosis Regulation Of Insulin Secretion Positive Regulation Of Transport Regulation Of Glucagon Secretion Vesicle-mediated Cholesterol Transport Phagosome-lysosome Fusion Calcium-dependent Activation Of Synaptic Vesicle Fusion Regulation Of Synaptic Vesicle Endocytosis Short-term Synaptic Potentiation Calcium Ion Regulated Lysosome Exocytosis
Pathways		Neurexins and neuroligins
Drugs
Diseases
GWAS		Intelligence (MTAG) ( 29326435) Mean arterial pressure ( 26390057) Metabolite levels ( 23823483) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311)
Novel Interacting Genes		1 novel interacting genes: FADS2
Interacting Genes		8 interacting genes: AP2A1 NRXN1 SIAH1 STX1A STX2 STX3 STX4 SYNCRIP
Entrez ID		9066
HPRD ID		11965
Ensembl ID		ENSG00000011347
Uniprot IDs		O43581
PDB IDs		2D8K
Enriched GO Terms of Interacting Partners?		SNAP Receptor Activity SNARE Complex SNARE Binding Vesicle Docking Organelle Localization By Membrane Tethering Membrane Docking Vesicle Fusion Neurotransmitter Transport Organelle Membrane Fusion Organelle Fusion Positive Regulation Of Synaptic Transmission Secretion By Cell Membrane Fusion Organelle Localization Exocytosis Secretion Membrane Assembly Intracellular Protein Transport Cornified Envelope Assembly Glutamatergic Synapse Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Endomembrane System Calcium-dependent Protein Binding Positive Regulation Of Protein Localization To Cell Periphery Membrane Organization Positive Regulation Of Protein Localization To Membrane Establishment Of Protein Localization Vesicle-mediated Transport In Synapse Vesicle Organization Schaffer Collateral - CA1 Synapse SNARE Complex Assembly Specific Granule Regulation Of Protein Localization To Plasma Membrane Cellular Localization Establishment Of Localization In Cell Vacuole Positive Regulation Of Protein Localization To Cell Surface Regulation Of Biological Quality Regulation Of Protein Localization To Cell Periphery Intracellular Protein Localization Modulation Of Chemical Synaptic Transmission Regulation Of Protein Localization To Membrane Presynaptic Active Zone Membrane Protein Transport Lamellipodium Positive Regulation Of Excitatory Postsynaptic Potential Vesicle-mediated Transport Intracellular Transport Synaptic Vesicle Endocytosis
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