SYT3 and MRM1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SYT3	MRM1
Description		synaptotagmin 3	mitochondrial rRNA methyltransferase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endosome Plasma Membrane Membrane Transport Vesicle Membrane Cytoplasmic Vesicle Synapse Exocytic Vesicle	Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	SNARE Binding Protein Binding Calcium-dependent Phospholipid Binding Metal Ion Binding Calcium Ion Sensor Activity	RNA Binding Protein Binding Methyltransferase Activity RNA Methyltransferase Activity RRNA (guanine) Methyltransferase Activity Transferase Activity RRNA (guanosine-2'-O-)-methyltransferase Activity
	Biological Process	Chemical Synaptic Transmission Vesicle-mediated Transport Regulation Of Calcium Ion-dependent Exocytosis Cell Differentiation Positive Regulation Of Vesicle Fusion Positive Regulation Of Dendrite Extension	RRNA Modification RRNA 2'-O-methylation RRNA Processing RNA Processing RRNA Methylation Methylation
Pathways			rRNA modification in the mitochondrion
Drugs
Diseases
GWAS		Adult body size ( 32376654) Superior frontal gyrus volume ( 31530798) Waist circumference ( 28552196)	Body mass index ( 26426971) Carotid intima media thickness x smoking interaction ( 32117412)
Interacting Genes		9 interacting genes: AP2A1 GRIA2 IQSEC1 KCNJ6 MRM1 SNAP25 SNCA SYNCRIP SYT5	42 interacting genes: ADIPOQ AGTRAP AQP1 AQP2 AQP3 BRICD5 CCL4 CCL4L2 CDC42 CMTM3 CMTM5 CNIH1 COQ8A DNAJC30 EEF1A1 ERG28 ESRRG FKBP7 ITGAM KLRG1 LPAR3 MAL2 MESD MGST3 NRM NXPE3 RHBDD2 RNASE10 SELENOK SPX STATH STX7 SYP SYT3 TMEM11 TMEM243 TMEM42 TMEM97 TRARG1 TTPA VKORC1L1 VSTM1
Entrez ID		84258	79922
HPRD ID		08977	08656
Ensembl ID		ENSG00000213023	ENSG00000278619
Uniprot IDs		Q9BQG1	Q6IN84
PDB IDs
Enriched GO Terms of Interacting Partners?		Synaptic Vesicle SNARE Binding Postsynaptic Endocytic Zone Vesicle-mediated Transport In Synapse Chemical Synaptic Transmission Trans-synaptic Signaling Synaptic Signaling Synaptic Vesicle Priming Synapse Positive Regulation Of Vesicle Fusion Modulation Of Chemical Synaptic Transmission Neurotransmitter Uptake Synaptic Vesicle Exocytosis Regulation Of Vesicle Fusion Import Into Cell Synaptic Vesicle Endocytosis Signaling Cell-cell Signaling Neurotransmitter Secretion Presynaptic Endocytosis Cell Communication Long-term Synaptic Potentiation Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Receptor Internalization Regulation Of Transport Lipid Binding Endocytic Vesicle Membrane Neuronal Cell Body Voltage-gated Potassium Channel Complex Regulation Of Neurotransmitter Secretion Axon Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process RRNA (guanosine-2'-O-)-methyltransferase Activity Regulation Of Postsynaptic Membrane Potential Neurotransmitter Transport Response To Type II Interferon Regulated Exocytosis Establishment Of Vesicle Localization Ligand-gated Monoatomic Cation Channel Activity Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Proximal Neuron Projection RRNA (guanine) Methyltransferase Activity	Polyol Transmembrane Transport Renal Water Transport Glycerol Transmembrane Transport Carbohydrate Transport Carbohydrate Transmembrane Transport Water Channel Activity Glycerol Transmembrane Transporter Activity Membrane Renal Water Homeostasis Cellular Response To Mercury Ion Water Transport Multicellular Organismal-level Water Homeostasis Water Transmembrane Transporter Activity Renal Water Absorption Fluid Transport Channel Activity Cytokine Activity Response To Mercury Ion Response To Bacterium Positive Regulation Of Monocyte Chemotactic Protein-1 Production
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