SYT3 and SNAP25

Number of citations of the paper that reports this interaction (PMID 10692432)
44

Data Source:
HPRD (in vitro)

		SYT3	SNAP25
Gene Name		synaptotagmin III	synaptosomal-associated protein, 25kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endosome Integral Component Of Membrane Cell Junction Synaptic Vesicle Membrane	Cytoplasm Trans-Golgi Network Cytosol Plasma Membrane Membrane Cell Junction Growth Cone BLOC-1 Complex SNARE Complex Vesicle Presynaptic Membrane Neuron Projection Perinuclear Region Of Cytoplasm Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex
	Molecular Function	Phosphatidylserine Binding Transporter Activity Calcium-dependent Phospholipid Binding Syntaxin Binding Clathrin Binding Metal Ion Binding	SNAP Receptor Activity Protein Binding Syntaxin-1 Binding Calcium-dependent Protein Binding
	Biological Process	Calcium Ion-dependent Exocytosis Positive Regulation Of Vesicle Fusion Response To Calcium Ion	Neurotransmitter Uptake Energy Reserve Metabolic Process Synaptic Transmission Neurotransmitter Secretion Pathogenesis Regulation Of Neuron Projection Development Glutamate Secretion Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Synaptic Vesicle Priming Synaptic Vesicle Fusion To Presynaptic Membrane Small Molecule Metabolic Process Regulation Of Insulin Secretion Long-term Synaptic Potentiation Regulation Of Establishment Of Protein Localization
Pathways			Dopamine Neurotransmitter Release Cycle Integration of energy metabolism Toxicity of botulinum toxin type E (BoNT/E) Toxicity of botulinum toxin type A (BoNT/A) Acetylcholine Neurotransmitter Release Cycle Regulation of insulin secretion Toxicity of botulinum toxin type C (BoNT/C) Norepinephrine Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation Glutamate Neurotransmitter Release Cycle Uptake and actions of bacterial toxins Neurotransmitter Release Cycle Neurotoxicity of clostridium toxins Serotonin Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs			Botulinum Toxin Type A
Diseases
GWAS			Cardiac hypertrophy ( 21348951)
Protein-Protein Interactions		4 interactors: AP2A1 SNAP25 SYNCRIP SYT5	34 interactors: APP CCDC53 CENPF CPLX1 DNM1 GOSR1 HGS ITSN1 KCNB1 KIF5B NAPA PRKACA PRKCA PRRT2 RIMS1 SCAMP1 SNAPIN SRCIN1 STX11 STX12 STX1A STX2 STX3 STX4 STX5 STXBP6 SYT1 SYT3 SYT9 TRIM9 VAMP2 VAMP7 VAMP8 ZDHHC17
Entrez ID		84258	6616
HPRD ID		08977	02637
Ensembl ID		ENSG00000213023	ENSG00000132639
Uniprot IDs		Q9BQG1	P60880
PDB IDs			1KIL 1XTG 3RK2 3RK3 3RL0 3ZUR
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Energy Reserve Metabolic Process Cell-cell Signaling Regulation Of Insulin Secretion Negative Regulation Of Hyaluronan Biosynthetic Process Regulation Of Peptide Hormone Secretion Regulation Of Hormone Secretion CRD-mediated MRNA Stabilization Vesicle-mediated Transport Energy Derivation By Oxidation Of Organic Compounds Exocytosis Synaptic Vesicle Docking Synaptic Vesicle Priming Regulation Of Protein Secretion Synaptic Vesicle Fusion To Presynaptic Membrane Generation Of Precursor Metabolites And Energy Neurotransmitter Uptake Establishment Of Localization In Cell Secretion By Cell Golgi To Endosome Transport Viral Process Cellular Localization Regulation Of Protein Transport Glutamate Secretion Secretion Regulation Of Defense Response To Virus By Virus Regulation Of Secretion MRNA Stabilization Regulation Of Establishment Of Protein Localization Clathrin-mediated Endocytosis Regulation Of Protein Localization Calcium Ion-dependent Exocytosis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Signaling Negative Regulation Of ERBB Signaling Pathway Long-term Synaptic Potentiation Vesicle Fusion Regulation Of MRNA Stability Synaptic Vesicle Exocytosis Regulation Of RNA Stability Acid Secretion Vesicle Docking Involved In Exocytosis Cell Differentiation Regulation Of Cellular Localization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Organelle Fusion Regulation Of ERBB Signaling Pathway Vesicle Docking Regulation Of Defense Response To Virus Dicarboxylic Acid Transport	Membrane Fusion Exocytosis Vesicle-mediated Transport Vesicle Fusion Synaptic Vesicle Exocytosis Synaptic Vesicle Transport Establishment Of Localization In Cell Secretion By Cell Organelle Fusion Establishment Of Vesicle Localization Vesicle Localization Regulation Of Exocytosis Secretion Neurotransmitter Secretion Cellular Localization Transport Establishment Of Organelle Localization Regulation Of Cellular Localization Synaptic Transmission Regulation Of Neurotransmitter Levels Regulation Of Secretion Organelle Localization Neurotransmitter Transport Membrane Organization Regulation Of Vesicle-mediated Transport Synaptic Vesicle Fusion To Presynaptic Membrane Protein Transport Vesicle Organization Establishment Of Protein Localization Cell-cell Signaling Vesicle Docking Intracellular Transport Membrane Docking Protein Localization Positive Regulation Of Exocytosis Calcium Ion-dependent Exocytosis Regulation Of Hormone Secretion Intracellular Protein Transport Regulation Of Cellular Component Organization Positive Regulation Of Transport Glutamate Secretion Regulation Of Synaptic Transmission Golgi Vesicle Transport Post-Golgi Vesicle-mediated Transport Regulation Of Protein Localization Positive Regulation Of Synaptic Transmission Regulation Of Insulin Secretion Cellular Protein Localization Regulation Of Peptide Hormone Secretion Acid Secretion
Tagcloud ?			anterograde axonal axons blunt breakdown bulbous bulbs caudate circumscribed disorganized immunocytochemical immunoreactivity insult map5 mca neurofilament nf68kd nonischemic occlusion permeating precedes reminiscent roughened sequalae subcortical swellings synaptosomal territory tracts
Tagcloud (Difference) ?			anterograde axonal axons blunt breakdown bulbous bulbs caudate circumscribed disorganized immunocytochemical immunoreactivity insult map5 mca neurofilament nf68kd nonischemic occlusion permeating precedes reminiscent roughened sequalae subcortical swellings synaptosomal territory tracts
Tagcloud (Intersection) ?