Wiki-Pi
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PIK3CG
Gene Name
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
Image
Gene Ontology Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Phosphatidylinositol 3-kinase Complex, Class IB
Membrane
Mast Cell Granule
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
1-phosphatidylinositol-3-kinase Activity
Phosphatidylinositol 3-kinase Activity
1-phosphatidylinositol-4-phosphate 3-kinase Activity
Ephrin Receptor Binding
Phosphatidylinositol-4,5-bisphosphate 3-kinase Activity
Biological Process
Angiogenesis
Cytokine Production
Adaptive Immune Response
Dendritic Cell Chemotaxis
Positive Regulation Of Acute Inflammatory Response
Respiratory Burst Involved In Defense Response
Protein Phosphorylation
Phospholipid Metabolic Process
Phosphatidylinositol Biosynthetic Process
Endocytosis
Inflammatory Response
G-protein Coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Blood Coagulation
T Cell Chemotaxis
Negative Regulation Of Triglyceride Catabolic Process
Phosphatidylinositol 3-kinase Signaling
Platelet Activation
Neutrophil Chemotaxis
Secretory Granule Localization
Regulation Of Cell Adhesion Mediated By Integrin
Natural Killer Cell Chemotaxis
Phosphatidylinositol-3-phosphate Biosynthetic Process
T Cell Proliferation
T Cell Activation
Mast Cell Degranulation
Positive Regulation Of MAP Kinase Activity
Small Molecule Metabolic Process
Innate Immune Response
Phosphatidylinositol Phosphorylation
Positive Regulation Of Protein Kinase B Signaling
Negative Regulation Of Cardiac Muscle Contraction
Platelet Aggregation
Neutrophil Extravasation
Hepatocyte Apoptotic Process
Negative Regulation Of Fibroblast Apoptotic Process
Pathways
Synthesis of PIPs at the plasma membrane
Signaling by GPCR
GPCR downstream signaling
Metabolism of lipids and lipoproteins
G-protein beta:gamma signalling
G beta:gamma signalling through PI3Kgamma
GPVI-mediated activation cascade
Phospholipid metabolism
Platelet activation, signaling and aggregation
PI Metabolism
Drugs
Staurosporine
Myricetin
2-(4-Morpholinyl)-8-Phenyl-4h-1-Benzopyran-4-One
Quercetin
5-QUINOXALIN-6-YLMETHYLENE-THIAZOLIDINE-2,4-DIONE
2-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONE
N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)- PHENYLTHIAZOLE-2-YL)-ACETAMIDE
5,5-dimethyl-2-morpholin-4-yl-5,6-dihydro-1,3-benzothiazol-7(4H)-one
3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL
(5E)-5-[(2,2-DIFLUORO-1,3-BENZODIOXOL-5-YL)METHYLENE]-1,3-THIAZOLIDINE-2,4-DIONE
(1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE
1-methyl-3-naphthalen-2-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Diseases
GWAS
Blood pressure (
21909110
)
Carotid intima media thickness (
21909108
)
Mean platelet volume (
22139419
19820697
22423221
)
Platelet counts (
22139419
)
Protein-protein Interactions
22 interactors:
ADRBK1
BCR
CD28
EPHA8
GAB1
GRB2
GSN
HRAS
IL6ST
KIT
KRAS
LYN
NOTCH1
NRAS
PIK3CD
PIK3R5
PTPN11
SEC14L2
SET
SMPD2
TPM2
ZNF282
Entrez ID
5294
HPRD ID
03135
Ensembl ID
ENSG00000105851
Uniprot IDs
A8K9G9
P48736
PDB IDs
1E8Y
1E8Z
1HE8
2A4Z
2A5U
2CHW
2CHX
2CHZ
2V4L
3APC
3APD
3APF
3CSF
3CST
3DBS
3DPD
3ENE
3IBE
3L08
3L13
3L16
3L17
3L54
3LJ3
3MJW
3ML8
3ML9
3NZS
3NZU
3OAW
3P2B
3PRE
3PRZ
3PS6
3QAQ
3QAR
3QJZ
3QK0
3R7Q
3R7R
3S2A
3SD5
3T8M
3TJP
3TL5
3ZVV
3ZW3
4ANU
4ANV
4ANW
4ANX
4AOF
4DK5
4EZJ
4EZK
4EZL
4F1S
4FA6
4FAD
4FHJ
4FHK
4FJY
4FJZ
4FLH
4FUL
4G11
4GB9
4HLE
4KZ0
4KZC
Enriched GO Terms of Interacting Partners
?
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Cellular Response To Fibroblast Growth Factor Stimulus
Response To Fibroblast Growth Factor
Fc-epsilon Receptor Signaling Pathway
Fc Receptor Signaling Pathway
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Phosphatidylinositol-mediated Signaling
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Immune Response
Immune Response-regulating Signaling Pathway
Positive Regulation Of Signal Transduction
Response To Organic Substance
Regulation Of Immune System Process
Cell Surface Receptor Signaling Pathway
Leukocyte Migration
Regulation Of Intracellular Signal Transduction
Innate Immune Response
Intracellular Signal Transduction
Cellular Response To Organic Substance
Regulation Of MAPK Cascade
Positive Regulation Of Kinase Activity
Immune Response
Defense Response
Regulation Of Signal Transduction
Positive Regulation Of Transferase Activity
Response To External Stimulus
Positive Regulation Of Metabolic Process
Cellular Response To Hormone Stimulus
Cell Migration
Wound Healing
Regulation Of Catalytic Activity
Chemotaxis
Positive Regulation Of Phosphorylation
Cell Motility
Regulation Of Signaling
Positive Regulation Of MAPK Cascade
Positive Regulation Of Cellular Metabolic Process
Insulin Receptor Signaling Pathway
Signal Transduction
Regulation Of Phosphorylation
Response To Wounding
Regulation Of MAP Kinase Activity
Tagcloud
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422a
akt3
circuit
differentially
dysregulated
effectors
encode
gleason
grades
kallikrein
kallikreins
klk14
klk15
klk2
klk3
klk4
micrornas
microsatellite
minisatellite
mirna
mirnas
nucleotides
prostate
proteases
pseudogene
repeats
share
silico
talk