AGR3 and DESI1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AGR3	DESI1
Description		anterior gradient 3, protein disulphide isomerase family member	desumoylating isopeptidase 1
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GO Annotations	Cellular Component	Endoplasmic Reticulum	Nucleus Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Dystroglycan Binding Protein Binding	Protein Binding Peptidase Activity Palmitoyl-(protein) Hydrolase Activity Hydrolase Activity DeSUMOylase Activity Identical Protein Binding Long-chain Fatty Acyl-CoA Hydrolase Activity Importin-alpha Family Protein Binding
	Biological Process		Proteolysis Protein Export From Nucleus Protein Desumoylation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Macromolecule Depalmitoylation
Pathways
Drugs
Diseases
GWAS		Coffee consumption ( 29367735 31959922) Cutaneous malignant melanoma ( 26237428 32341527) Cutaneous squamous cell carcinoma ( 32041948) Diffusing capacity of carbon monoxide ( 30694715) Lung cancer in ever smokers ( 28604730) Melanoma ( 28212542) Refractive error ( 32231278) Residual cognition ( 28441426) Rosacea symptom severity ( 29771307) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432)	General cognitive ability ( 29844566) Meat-related diet ( 32066663) Neuroticism ( 29255261) Refractive error ( 32231278)
Interacting Genes		35 interacting genes: AKT1 AP1B1 APC ASB10 BCAR3 CASP8 CATSPER1 CD46 CGRRF1 CNNM3 DAG1 DESI1 EDA2R ERLIN1 ESR2 FXYD3 KRTAP11-1 LIME1 LSM1 LYPD3 MMGT1 NRM NTAQ1 NUP62 PDZK1IP1 PRAF2 PTPN1 SGTA SGTB SPINT1 TGFB1 TIMMDC1 TMEM14B UBQLN1 UBQLN2	32 interacting genes: ABI3 AGR3 CCDC158 CDIP1 CDSN CTAG1A CTAG1B CTAG2 DAZAP2 ERP29 EVI2B FGF7 GOLM1 KLRF1 MEOX2 NME3 NT5C3A PRR5 RNF4 RPS27A SHISA4 SHISA5 SMIM21 TAS2R41 UBA52 UBB UBC UBQLN1 UBQLNL UHRF2 XPO1 ZBTB46
Entrez ID		155465	27351
HPRD ID		16545	18590
Ensembl ID		ENSG00000173467	ENSG00000100418
Uniprot IDs		Q8TD06	Q6ICB0
PDB IDs		3PH9	3EBQ
Enriched GO Terms of Interacting Partners?		Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Response To Endoplasmic Reticulum Stress TRC Complex Positive Regulation Of ERAD Pathway Response To Endoplasmic Reticulum Stress Regulation Of Proteolysis Regulation Of ERAD Pathway Insulin Receptor Signaling Pathway Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Glial Cell Differentiation ERAD Pathway Positive Regulation Of Protein Catabolic Process Membrane Positive Regulation Of Protein Localization To Centrosome Positive Regulation Of Proteasomal Protein Catabolic Process Response To Fluid Shear Stress Regulation Of Protein Catabolic Process Proteolysis Negative Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Establishment Of Protein Localization Cellular Response To Decreased Oxygen Levels Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Protein Catabolic Process Negative Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Protein Localization To Centrosome Cellular Response To Oxygen Levels Positive Regulation Of Gliogenesis Regulation Of Sodium Ion Transport Regulation Of Glial Cell Differentiation Vascular Endothelial Cell Response To Fluid Shear Stress Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of Fibroblast Migration Positive Regulation Of Macrophage Differentiation Cellular Response To Mechanical Stimulus Regulation Of Canonical NF-kappaB Signal Transduction Tail-anchored Membrane Protein Insertion Into ER Membrane Lamellipodium Regulation Of Metal Ion Transport Laminin Binding Regulation Of Protein Metabolic Process Establishment Of Protein Localization To Membrane Response To Laminar Fluid Shear Stress Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Catabolic Process Autophagosome Assembly Positive Regulation Of Endothelial Cell Apoptotic Process	Protein Tag Activity TRNA Threonylcarbamoyladenosine Metabolic Process Modification-dependent Protein Catabolic Process Endocytic Vesicle Membrane Ubiquitin Protein Ligase Binding Mitochondrial Outer Membrane Proteolysis Involved In Protein Catabolic Process Protein Ubiquitination Regulation Of Granulocyte Differentiation Protein Modification By Small Protein Conjugation Vesicle
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