AGR3 and SPINT1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AGR3	SPINT1
Description		anterior gradient 3, protein disulphide isomerase family member	serine peptidase inhibitor, Kunitz type 1
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GO Annotations	Cellular Component	Endoplasmic Reticulum	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Dystroglycan Binding Protein Binding	Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity
	Biological Process		Neural Tube Closure Embryonic Placenta Development Epidermis Development Extracellular Matrix Organization Positive Regulation Of Glial Cell Differentiation Epithelium Development Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development Cellular Response To BMP Stimulus Negative Regulation Of Neural Precursor Cell Proliferation
Pathways			MET Receptor Activation Signaling by MST1
Drugs
Diseases
GWAS		Coffee consumption ( 29367735 31959922) Cutaneous malignant melanoma ( 26237428 32341527) Cutaneous squamous cell carcinoma ( 32041948) Diffusing capacity of carbon monoxide ( 30694715) Lung cancer in ever smokers ( 28604730) Melanoma ( 28212542) Refractive error ( 32231278) Residual cognition ( 28441426) Rosacea symptom severity ( 29771307) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432)	Blood protein levels ( 30072576) Malaria ( 31844061) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		35 interacting genes: AKT1 AP1B1 APC ASB10 BCAR3 CASP8 CATSPER1 CD46 CGRRF1 CNNM3 DAG1 DESI1 EDA2R ERLIN1 ESR2 FXYD3 KRTAP11-1 LIME1 LSM1 LYPD3 MMGT1 NRM NTAQ1 NUP62 PDZK1IP1 PRAF2 PTPN1 SGTA SGTB SPINT1 TGFB1 TIMMDC1 TMEM14B UBQLN1 UBQLN2	23 interacting genes: ADAM33 AGR3 CLDN11 CLEC7A FAM3C HGFAC HMGB1 KRTAP1-3 MAL NLGN3 SLC38A7 SMCO4 ST14 TENT5A TF TMEM109 TMEM190 TMEM97 TSPAN33 UBQLN2 UBQLN4 UPK1B VAMP5
Entrez ID		155465	6692
HPRD ID		16545	05494
Ensembl ID		ENSG00000173467	ENSG00000166145
Uniprot IDs		Q8TD06	O43278
PDB IDs		3PH9	1YC0 2MSX 4ISL 4ISN 4ISO 5EZD 5H7V
Enriched GO Terms of Interacting Partners?		Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Response To Endoplasmic Reticulum Stress TRC Complex Positive Regulation Of ERAD Pathway Response To Endoplasmic Reticulum Stress Regulation Of Proteolysis Regulation Of ERAD Pathway Insulin Receptor Signaling Pathway Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Glial Cell Differentiation ERAD Pathway Positive Regulation Of Protein Catabolic Process Membrane Positive Regulation Of Protein Localization To Centrosome Positive Regulation Of Proteasomal Protein Catabolic Process Response To Fluid Shear Stress Regulation Of Protein Catabolic Process Proteolysis Negative Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Establishment Of Protein Localization Cellular Response To Decreased Oxygen Levels Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Protein Catabolic Process Negative Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Protein Localization To Centrosome Cellular Response To Oxygen Levels Positive Regulation Of Gliogenesis Regulation Of Sodium Ion Transport Regulation Of Glial Cell Differentiation Vascular Endothelial Cell Response To Fluid Shear Stress Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of Fibroblast Migration Positive Regulation Of Macrophage Differentiation Cellular Response To Mechanical Stimulus Regulation Of Canonical NF-kappaB Signal Transduction Tail-anchored Membrane Protein Insertion Into ER Membrane Lamellipodium Regulation Of Metal Ion Transport Laminin Binding Regulation Of Protein Metabolic Process Establishment Of Protein Localization To Membrane Response To Laminar Fluid Shear Stress Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Catabolic Process Autophagosome Assembly Positive Regulation Of Endothelial Cell Apoptotic Process	Positive Regulation Of Wound Healing Cell Surface Positive Regulation Of Monocyte Chemotactic Protein-1 Production Basal Part Of Cell
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