AGR3 and DAG1

Number of citations of the paper that reports this interaction (PubMedID 12592373)
18

Data Source:
HPRD (two hybrid)

		AGR3	DAG1
Description		anterior gradient 3, protein disulphide isomerase family member	dystroglycan 1
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum	Golgi Membrane Extracellular Region Basement Membrane Extracellular Space Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Golgi Lumen Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Adherens Junction Focal Adhesion External Side Of Plasma Membrane Cell Surface Dystrophin-associated Glycoprotein Complex Dystroglycan Complex Membrane Basolateral Plasma Membrane Lamellipodium Filopodium Extracellular Matrix Node Of Ranvier Nuclear Periphery Sarcolemma Costamere Plasma Membrane Raft Membrane Raft Synapse Postsynaptic Membrane Extracellular Exosome Contractile Ring Photoreceptor Ribbon Synapse Postsynapse Glutamatergic Synapse GABA-ergic Synapse Postsynaptic Cytosol
	Molecular Function	Dystroglycan Binding Protein Binding	Virus Receptor Activity Dystroglycan Binding Actin Binding Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Tubulin Binding Vinculin Binding SH2 Domain Binding Laminin Binding Laminin-1 Binding Protein-containing Complex Binding Alpha-actinin Binding
	Biological Process		Positive Regulation Of Cell-matrix Adhesion Morphogenesis Of An Epithelium Morphogenesis Of An Epithelial Sheet Heart Morphogenesis Membrane Protein Ectodomain Proteolysis Axon Guidance Heart Development Schwann Cell Differentiation Schwann Cell Development Response To Muscle Activity Response To Denervation Involved In Regulation Of Muscle Adaptation Protein Transport Muscle Attachment Calcium-dependent Cell-matrix Adhesion Nerve Development Nerve Maturation Myelination In Peripheral Nervous System Extracellular Matrix Organization Negative Regulation Of Cell Migration Axon Regeneration Positive Regulation Of Myelination Microtubule Anchoring Skeletal Muscle Tissue Regeneration Negative Regulation Of MAPK Cascade Response To Peptide Hormone Symbiont Entry Into Host Cell Regulation Of Synaptic Plasticity Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Synapse Organization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Angiogenesis Involved In Wound Healing Epithelial Tube Branching Involved In Lung Morphogenesis Branching Involved In Salivary Gland Morphogenesis Cellular Response To Mechanical Stimulus Cellular Response To Cholesterol Commissural Neuron Axon Guidance Basement Membrane Organization Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Retrograde Trans-synaptic Signaling By Trans-synaptic Protein Complex
Pathways			Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 DAG1 core M2 glycosylations DAG1 core M3 glycosylations DAG1 core M1 glycosylations Regulation of expression of SLITs and ROBOs EGR2 and SOX10-mediated initiation of Schwann cell myelination Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Matriglycan biosynthesis on DAG1
Drugs
Diseases			Limb-girdle muscular dystrophy (LGMD)
GWAS		Coffee consumption ( 29367735 31959922) Cutaneous malignant melanoma ( 26237428 32341527) Cutaneous squamous cell carcinoma ( 32041948) Diffusing capacity of carbon monoxide ( 30694715) Lung cancer in ever smokers ( 28604730) Melanoma ( 28212542) Refractive error ( 32231278) Residual cognition ( 28441426) Rosacea symptom severity ( 29771307) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432)	A body shape index ( 34021172) Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 31152163) Extremely high intelligence ( 29520040) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 28067908) Intelligence (MTAG) ( 29326435) Mood instability ( 31168069) Pediatric autoimmune diseases ( 26301688) Plateletcrit ( 32888494) Refractive error ( 32231278) Regular attendance at a religious group ( 29970889) Resting heart rate ( 27798624) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		35 interacting genes: AKT1 AP1B1 APC ASB10 BCAR3 CASP8 CATSPER1 CD46 CGRRF1 CNNM3 DAG1 DESI1 EDA2R ERLIN1 ESR2 FXYD3 KRTAP11-1 LIME1 LSM1 LYPD3 MMGT1 NRM NTAQ1 NUP62 PDZK1IP1 PRAF2 PTPN1 SGTA SGTB SPINT1 TGFB1 TIMMDC1 TMEM14B UBQLN1 UBQLN2	26 interacting genes: AGR2 AGR3 AGRN BGN CAV1 CAV3 DMD DRP2 FYN GRB2 HMGB1 ITGB1 LAMA1 LAMA2 LAMA5 MAGI1 MAP2 NCK1 RAPSN SHC1 SRC TLN1 TUBA1A UTRN WWP1 WWP2
Entrez ID		155465	1605
HPRD ID		16545	00546
Ensembl ID		ENSG00000173467	ENSG00000173402
Uniprot IDs		Q8TD06	Q14118
PDB IDs		3PH9	1EG4 2MK7 5GGP 5LLK 6JJY 7E9K 7E9L
Enriched GO Terms of Interacting Partners?		Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Response To Endoplasmic Reticulum Stress TRC Complex Positive Regulation Of ERAD Pathway Response To Endoplasmic Reticulum Stress Regulation Of Proteolysis Regulation Of ERAD Pathway Insulin Receptor Signaling Pathway Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Glial Cell Differentiation ERAD Pathway Positive Regulation Of Protein Catabolic Process Membrane Positive Regulation Of Protein Localization To Centrosome Positive Regulation Of Proteasomal Protein Catabolic Process Response To Fluid Shear Stress Regulation Of Protein Catabolic Process Proteolysis Negative Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Establishment Of Protein Localization Cellular Response To Decreased Oxygen Levels Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Protein Catabolic Process Negative Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Protein Localization To Centrosome Cellular Response To Oxygen Levels Positive Regulation Of Gliogenesis Regulation Of Sodium Ion Transport Regulation Of Glial Cell Differentiation Vascular Endothelial Cell Response To Fluid Shear Stress Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of Fibroblast Migration Positive Regulation Of Macrophage Differentiation Cellular Response To Mechanical Stimulus Regulation Of Canonical NF-kappaB Signal Transduction Tail-anchored Membrane Protein Insertion Into ER Membrane Lamellipodium Regulation Of Metal Ion Transport Laminin Binding Regulation Of Protein Metabolic Process Establishment Of Protein Localization To Membrane Response To Laminar Fluid Shear Stress Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Catabolic Process Autophagosome Assembly Positive Regulation Of Endothelial Cell Apoptotic Process	Dystroglycan Binding Neuromuscular Junction Regulation Of Cell Adhesion Positive Regulation Of Cell Adhesion Ephrin Receptor Binding Sarcolemma Muscle Organ Development Muscle Structure Development Regulation Of Cellular Component Organization Integrin Binding Developmental Process Plasma Membrane Regulation Of Developmental Process Regulation Of Multicellular Organismal Development Membrane Raft Nitric-oxide Synthase Binding T Cell Costimulation Regulation Of Metal Ion Transport Positive Regulation Of Cell-cell Adhesion Vinculin Binding Extracellular Matrix Structural Constituent Regulation Of Cell Migration Symbiont Entry Into Host Cell Regulation Of Multicellular Organismal Process Cytoskeleton Organization Regulation Of Cell Motility Dystrophin-associated Glycoprotein Complex Signaling Receptor Binding Transmembrane Transporter Binding Regulation Of Monoatomic Ion Transport Regulation Of Locomotion Cell Surface Receptor Signaling Pathway Positive Regulation Of T Cell Activation Regulation Of Monoatomic Cation Transmembrane Transport Negative Regulation Of Anoikis Cell Projection Organization Animal Organ Development Positive Regulation Of Leukocyte Cell-cell Adhesion Cell Adhesion Biological Process Involved In Interaction With Host Receptor Internalization Plasma Membrane Bounded Cell Projection Organization Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of MAPK Cascade Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Organelle Organization Regulation Of Anoikis
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