CTSV and BUB1

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		CTSV	BUB1
Description		cathepsin V	BUB1 mitotic checkpoint serine/threonine kinase
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Lysosomal Lumen	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Nucleoplasm Chromosome Cytosol Membrane
	Molecular Function	Cysteine-type Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity Histone H2A Kinase Activity
	Biological Process	Proteolysis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Extracellular Matrix Disassembly Proteolysis Involved In Protein Catabolic Process	Chromatin Remodeling Apoptotic Process Chromosome Segregation Regulation Of Sister Chromatid Cohesion Mitotic Spindle Assembly Checkpoint Signaling Intracellular Signal Transduction Cell Division Meiotic Sister Chromatid Cohesion, Centromeric Regulation Of Chromosome Segregation Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric
Pathways		Endosomal/Vacuolar pathway Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Trafficking and processing of endosomal TLR Assembly of collagen fibrils and other multimeric structures MHC class II antigen presentation RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs		3-amino-5-phenylpentane 4-Methylpiperazin-1-Yl Carbonyl Group
Diseases
GWAS
Interacting Genes		13 interacting genes: APC BMPR1A BRAF BUB1 CDKN2A CTNNA1 DCC DLC1 MLH1 MLH3 PDGFRL RB1 SRC	64 interacting genes: AKT1 ALDOB ANP32B AOPEP AP1B1 AP2B1 AP3B1 AP4B1 APC ARIH2 BAAT BUB3 CCDC180 CDC14B CDC20 CDK1 CDK8 CORO2A CRK CTSV CYLC2 DVL1 EIF4EBP1 FANCC FBP1 FBP2 FBXO7 FRAT2 GALNT12 HDAC1 HEMGN HRAS HSD17B3 IGFBP3 KNL1 LEF1 MAP2K1 MAPK3 MSANTD3 NANS PLK1 PPP2CB PPP3R2 RAE1 RASA1 RDH12 SEC61B SFRP2 SFRP4 SHC1 SMAD1 STX17 SVIL TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRMO TSTD2 UBC XPA ZNF189 ZNF510
Entrez ID		1515	699
HPRD ID		04495	03907
Ensembl ID		ENSG00000136943	ENSG00000169679
Uniprot IDs		B2R717 O60911	B4DYG2 O43683
PDB IDs		1FH0 3H6S 3KFQ 7PK4 7Q8D 7Q8F 7Q8G 7Q8H 7Q8I 7Q8J 7Q8K 7Q8L 7Q8M 7Q8N 7Q8O 7Q8P 7Q8Q 7Q9H 7QFF 7QFH 7QGW 7QHJ 7QHK 7QNS 7QO2	2LAH 4A1G 4QPM 4R8Q 5DMZ 6F7B 7B1F 7B1H 7B1J
Enriched GO Terms of Interacting Partners?		Chiasma Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Anatomical Structure Morphogenesis Negative Regulation Of Nervous System Development Negative Regulation Of Cell Development Negative Regulation Of Neurogenesis Negative Regulation Of Cell-matrix Adhesion Mismatch Repair Complex Regulation Of Neurogenesis Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Cellular Component Organization Negative Regulation Of Kinase Activity Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cyclin-dependent Protein Kinase Activity Signal Transduction Negative Regulation Of Chromosome Organization Regulation Of Phosphorylation Intracellular Signal Transduction Regulation Of Mitotic Sister Chromatid Separation Gamma-catenin Binding Regulation Of Chromosome Organization Regulation Of Chromosome Separation Negative Regulation Of Protein Kinase Activity Regulation Of Cell Development Animal Organ Morphogenesis Somatic Stem Cell Population Maintenance Caveola Regulation Of Nervous System Development Apoptotic Process Regulation Of Cell-substrate Adhesion Negative Regulation Of Cell-substrate Adhesion Mismatched DNA Binding Regulation Of Kinase Activity ATP Binding Cell Junction Assembly Regulation Of Mitotic Metaphase/anaphase Transition Programmed Cell Death Cell Death Regulation Of Phosphorus Metabolic Process Odontogenesis Ruffle Membrane Negative Regulation Of Protein Phosphorylation Regulation Of Sister Chromatid Segregation Regulation Of Cell Motility ATP-dependent DNA Damage Sensor Activity Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Multicellular Organismal Process	Clathrin Adaptor Complex Regulation Of Organelle Organization Regulation Of Cellular Component Organization Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Cell Cycle Membrane Coat Cytosol Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Fructose 1,6-bisphosphate Metabolic Process Regulation Of Sister Chromatid Segregation Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Cytoskeleton Organization Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Sister Chromatid Separation Canonical Wnt Signaling Pathway Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Chromosome Separation Regulation Of Chromosome Segregation Insulin Receptor Signaling Pathway Negative Regulation Of Mitotic Cell Cycle Protein Localization To Kinetochore Positive Regulation Of Ubiquitin-protein Transferase Activity Phosphoric Ester Hydrolase Activity Fructose 1,6-bisphosphate 1-phosphatase Activity Golgi Inheritance Negative Regulation Of Mitotic Nuclear Division Intracellular Signal Transduction Fructose Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Regulation Of Cellular Localization Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Protein Localization Regulation Of Plasma Membrane Bounded Cell Projection Organization Phosphotyrosine Residue Binding Regulation Of Cell Projection Organization Regulation Of Chromosome Organization Positive Regulation Of Protein Localization Protein Kinase Binding Regulation Of Protein Localization To Membrane Gluconeogenesis Schwann Cell Development Negative Regulation Of Cell Cycle
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