CTSV and DLC1

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		CTSV	DLC1
Description		cathepsin V	DLC1 Rho GTPase activating protein
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Lysosomal Lumen	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Caveola Focal Adhesion Membrane Cortical Actin Cytoskeleton Ruffle Membrane Membrane Raft Anchoring Junction
	Molecular Function	Cysteine-type Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity	GTPase Activator Activity Protein Binding Lipid Binding SH2 Domain Binding
	Biological Process	Proteolysis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Extracellular Matrix Disassembly Proteolysis Involved In Protein Catabolic Process	Neural Tube Closure Heart Morphogenesis Signal Transduction Negative Regulation Of Cell Population Proliferation Hindbrain Morphogenesis Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Forebrain Development Regulation Of Rho Protein Signal Transduction Negative Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Focal Adhesion Assembly Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Stress Fiber Assembly Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of Execution Phase Of Apoptosis
Pathways		Endosomal/Vacuolar pathway Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Trafficking and processing of endosomal TLR Assembly of collagen fibrils and other multimeric structures MHC class II antigen presentation RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOQ GTPase cycle
Drugs		3-amino-5-phenylpentane 4-Methylpiperazin-1-Yl Carbonyl Group
Diseases
GWAS			Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Attention deficit hyperactivity disorder ( 30563984) Bipolar disorder ( 22688191) Emphysema imaging phenotypes ( 26030696) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Familial hepatitis B virus-related hepatocellular carcinoma ( 28662289) Fractional exhaled nitric oxide (childhood) ( 24315451) Gestational age at birth (child effect) ( 31194736) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Heel bone mineral density ( 30598549) Height ( 31562340) Intraocular pressure ( 29617998) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Late-onset Alzheimer's disease ( 27770636) LDL cholesterol levels in HIV infection ( 33109212) Lung adenocarcinoma ( 28604730) Metabolite levels ( 23823483) Mild obesity-related type 2 diabetes ( 34737425) Nicotine dependence symptom count ( 25555482) Nose size ( 27182965) Obesity-related traits ( 23251661) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507) Percentage gas trapping ( 26030696) Platelet distribution width ( 32888494) PR interval ( 32439900) Refractive error ( 32231278) Smoking initiation (ever regular vs never regular) ( 31089300) Waist-hip ratio ( 28552196)
Interacting Genes		13 interacting genes: APC BMPR1A BRAF BUB1 CDKN2A CTNNA1 DCC DLC1 MLH1 MLH3 PDGFRL RB1 SRC	35 interacting genes: ACOT7 AKT1 AOPEP BAAT CCDC180 CDC14B CORO2A CTSV FANCC FBP2 HEMGN HSD17B3 MAPK3 PFKM PKM PPP3R2 PTEN RANGAP1 RASA1 RHOA RPS6KA1 SFRP4 SMAD1 STX17 TDRD7 TGFB1 TMEFF1 TMEM129 TMOD1 TNS2 TRMO USP4 XPA ZNF189 ZNF510
Entrez ID		1515	10395
HPRD ID		04495	05035
Ensembl ID		ENSG00000136943	ENSG00000164741
Uniprot IDs		B2R717 O60911	A8K119 Q96QB1
PDB IDs		1FH0 3H6S 3KFQ 7PK4 7Q8D 7Q8F 7Q8G 7Q8H 7Q8I 7Q8J 7Q8K 7Q8L 7Q8M 7Q8N 7Q8O 7Q8P 7Q8Q 7Q9H 7QFF 7QFH 7QGW 7QHJ 7QHK 7QNS 7QO2	2DKY 2GYT 2KAP 2LOZ 3KUQ 5FZT 7TPB
Enriched GO Terms of Interacting Partners?		Chiasma Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Anatomical Structure Morphogenesis Negative Regulation Of Nervous System Development Negative Regulation Of Cell Development Negative Regulation Of Neurogenesis Negative Regulation Of Cell-matrix Adhesion Mismatch Repair Complex Regulation Of Neurogenesis Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Cellular Component Organization Negative Regulation Of Kinase Activity Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cyclin-dependent Protein Kinase Activity Signal Transduction Negative Regulation Of Chromosome Organization Regulation Of Phosphorylation Intracellular Signal Transduction Regulation Of Mitotic Sister Chromatid Separation Gamma-catenin Binding Regulation Of Chromosome Organization Regulation Of Chromosome Separation Negative Regulation Of Protein Kinase Activity Regulation Of Cell Development Animal Organ Morphogenesis Somatic Stem Cell Population Maintenance Caveola Regulation Of Nervous System Development Apoptotic Process Regulation Of Cell-substrate Adhesion Negative Regulation Of Cell-substrate Adhesion Mismatched DNA Binding Regulation Of Kinase Activity ATP Binding Cell Junction Assembly Regulation Of Mitotic Metaphase/anaphase Transition Programmed Cell Death Cell Death Regulation Of Phosphorus Metabolic Process Odontogenesis Ruffle Membrane Negative Regulation Of Protein Phosphorylation Regulation Of Sister Chromatid Segregation Regulation Of Cell Motility ATP-dependent DNA Damage Sensor Activity Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Multicellular Organismal Process	Phosphate-containing Compound Metabolic Process TORC1 Signaling Negative Regulation Of TOR Signaling TOR Signaling Negative Regulation Of Cell Adhesion Negative Regulation Of Transport Glucose Metabolic Process Negative Regulation Of Cell Size Thiolester Hydrolase Activity Fructose 1,6-bisphosphate Metabolic Process Intracellular Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of TORC1 Signaling Regulation Of Transcription By RNA Polymerase II Regulation Of TOR Signaling Hexose Metabolic Process Regulation Of Mononuclear Cell Migration Negative Regulation Of Cell-substrate Adhesion Long-chain Fatty Acyl-CoA Hydrolase Activity Fructose 6-phosphate Metabolic Process Negative Regulation Of Immune Response To Tumor Cell Myelin Maintenance Fatty Acyl-CoA Hydrolase Activity Lens Fiber Cell Differentiation Positive Regulation Of Catalytic Activity Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Fibroblast Migration Monosaccharide Metabolic Process Regulation Of Exit From Mitosis
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?