F5

Name	coagulation factor V
Structure
Novel Interactors	2 novel interactors: FCER1G FCGR2A
Interactors	11 interactors: CALR CSNK2A1 CTSG ELANE F10 F2 MMRN1 PROC PROS1 SERPINA3 SRPK2
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Membrane COPII-coated ER To Golgi Transport Vesicle Platelet Alpha Granule Platelet Alpha Granule Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Extracellular Vesicle
	Molecular Function	Copper Ion Binding Protein Binding Metal Ion Binding
	Biological Process	Blood Coagulation Hemostasis Blood Circulation Response To Vitamin K
Pathways	Platelet degranulation Common Pathway of Fibrin Clot Formation COPII-mediated vesicle transport Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cargo concentration in the ER Post-translational protein phosphorylation
Drugs	Drotrecogin alfa Thrombomodulin Alfa Thrombin Protein C Human thrombin Thrombin alfa Protein S human Anti-inhibitor coagulant complex
Diseases	Factor V deficiency; Owren disease Inherited thrombophilia
GWAS	Activated partial thromboplastin time ( 22703881 29403010 ) Cytokine network levels (multivariate analysis) ( 31679650 ) D-dimer levels ( 21502573 ) D-dimer levels in HIV infection ( 33095540 ) Hemostatic factors and hematological phenotypes ( 22443383 ) Hippocampal atrophy ( 22745009 ) Inflammatory biomarkers (multivariate analysis) ( 33110245 ) Iron status biomarkers (ferritin levels) ( 33536631 ) Iron status biomarkers (total iron binding capacity) ( 33536631 ) Ischemic stroke ( 26732560 ) Macrovascular complications in type 2 diabetes ( 33430853 ) Medication use (antithrombotic agents) ( 31015401 ) Optic disc area ( 31798171 25631615 ) Optic disc size ( 31809533 ) Peripheral artery disease ( 31285632 ) Plasma factor V levels in venous thrombosis ( 31271701 ) Prothrombin time ( 29403010 ) Stem cell growth factor beta levels ( 27989323 ) Thrombosis ( 26908601 ) Uric acid levels ( 23703922 ) Venous thromboembolism ( 32232851 33592630 31676865 31420334 28373160 25772935 23650146 22672568 21980494 ) Vertical cup-disc ratio ( 31798171 28073927 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 )
Entrez ID	2153
HPRD ID	01964
Ensembl ID	ENSG00000198734
Uniprot IDs	P12259
PDB IDs	1CZS 1CZT 1CZV 3P6Z 3P70 3S9C 7KVE 7KVF 7KXY 7TPP 8FDG 8TN9 9CTH
GO Terms Enriched among Interactors ?	Coagulation Blood Coagulation Hemostasis Serine-type Peptidase Activity Neutrophil-mediated Killing Of Bacterium Leukocyte Mediated Immunity Serine-type Endopeptidase Activity Regulation Of Platelet Activation Acute Inflammatory Response Negative Regulation Of Wound Healing Leukocyte Mediated Cytotoxicity Neutrophil Mediated Immunity Golgi Lumen Regulation Of Body Fluid Levels Killing By Host Of Symbiont Cells Extracellular Region Extracellular Space Calcium Ion Binding Biological Process Involved In Interaction With Symbiont Regulation Of Wound Healing External Side Of Plasma Membrane Neutrophil-mediated Killing Of Gram-negative Bacterium Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Immune Effector Process Regulation Of Response To Wounding Negative Regulation Of Coagulation Extracellular Matrix Cell Killing Peptidase Activity Platelet Alpha Granule Lumen Regulation Of Blood Coagulation Regulation Of Hemostasis Defense Response Positive Regulation Of Phagocytosis Azurophil Granule Lumen Positive Regulation Of Platelet Aggregation Endopeptidase Activity IgG Binding Regulation Of Multicellular Organismal Process Endoplasmic Reticulum Lumen Regulation Of Phagocytosis Acute Inflammatory Response To Antigenic Stimulus Response To Stress Response To Other Organism Positive Regulation Of Homotypic Cell-cell Adhesion Fibrinolysis Blood Microparticle Killing Of Cells Of Another Organism Negative Regulation Of Multicellular Organismal Process