F5 and SERPINA3

Number of citations of the paper that reports this interaction (PubMedID 8216224)
52

Data Source:
HPRD (in vitro)

		F5	SERPINA3
Description		coagulation factor V	serpin family A member 3
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Membrane COPII-coated ER To Golgi Transport Vesicle Platelet Alpha Granule Platelet Alpha Granule Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Extracellular Vesicle	Extracellular Region Extracellular Space Nucleus Extracellular Matrix Platelet Alpha Granule Lumen Secretory Granule Lumen Azurophil Granule Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	Copper Ion Binding Protein Binding Metal Ion Binding	DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity
	Biological Process	Blood Coagulation Hemostasis Blood Circulation Response To Vitamin K	Acute-phase Response Inflammatory Response Regulation Of Lipid Metabolic Process Maintenance Of Gastrointestinal Epithelium Response To Cytokine
Pathways		Platelet degranulation Common Pathway of Fibrin Clot Formation COPII-mediated vesicle transport Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cargo concentration in the ER Post-translational protein phosphorylation	Platelet degranulation Neutrophil degranulation
Drugs		Drotrecogin alfa Thrombomodulin Alfa Thrombin Protein C Human thrombin Thrombin alfa Protein S human Anti-inhibitor coagulant complex	Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Factor V deficiency; Owren disease Inherited thrombophilia
GWAS		Activated partial thromboplastin time ( 22703881 29403010) Cytokine network levels (multivariate analysis) ( 31679650) D-dimer levels ( 21502573) D-dimer levels in HIV infection ( 33095540) Hemostatic factors and hematological phenotypes ( 22443383) Hippocampal atrophy ( 22745009) Inflammatory biomarkers (multivariate analysis) ( 33110245) Iron status biomarkers (ferritin levels) ( 33536631) Iron status biomarkers (total iron binding capacity) ( 33536631) Ischemic stroke ( 26732560) Macrovascular complications in type 2 diabetes ( 33430853) Medication use (antithrombotic agents) ( 31015401) Optic disc area ( 31798171 25631615) Optic disc size ( 31809533) Peripheral artery disease ( 31285632) Plasma factor V levels in venous thrombosis ( 31271701) Prothrombin time ( 29403010) Stem cell growth factor beta levels ( 27989323) Thrombosis ( 26908601) Uric acid levels ( 23703922) Venous thromboembolism ( 32232851 33592630 31676865 31420334 28373160 25772935 23650146 22672568 21980494) Vertical cup-disc ratio ( 31798171 28073927) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Blood protein levels ( 30072576) Body mass index ( 23669352) Prostate-specific antigen levels ( 28139693) Serum total protein levels ( 29403010)
Interacting Genes		11 interacting genes: CALR CSNK2A1 CTSG ELANE F10 F2 MMRN1 PROC PROS1 SERPINA3 SRPK2	29 interacting genes: ABCC5 ADAMTS4 ADH1B APP CELA1 CFTR CMA1 CTRB1 CTRC CTRL CTSG DNAJC1 ELANE ERBB2 F5 HOXB1 HSP90AA1 KLK13 KLK2 KLK3 KLK4 LAMC3 LMNB1 MMP1 MST1 NFKB1 POLA1 POLR1H SGCD
Entrez ID		2153	12
HPRD ID		01964	00120
Ensembl ID		ENSG00000198734	ENSG00000196136
Uniprot IDs		P12259	P01011
PDB IDs		1CZS 1CZT 1CZV 3P6Z 3P70 3S9C 7KVE 7KVF 7KXY 7TPP 8FDG 8TN9 9CTH	1AS4 1QMN 2ACH 3CAA 3DLW 4CAA 6HGE 9C2T 9D7K
Enriched GO Terms of Interacting Partners?		Coagulation Blood Coagulation Hemostasis Serine-type Peptidase Activity Neutrophil-mediated Killing Of Bacterium Leukocyte Mediated Immunity Serine-type Endopeptidase Activity Regulation Of Platelet Activation Acute Inflammatory Response Negative Regulation Of Wound Healing Leukocyte Mediated Cytotoxicity Neutrophil Mediated Immunity Golgi Lumen Regulation Of Body Fluid Levels Killing By Host Of Symbiont Cells Extracellular Region Extracellular Space Calcium Ion Binding Biological Process Involved In Interaction With Symbiont Regulation Of Wound Healing External Side Of Plasma Membrane Neutrophil-mediated Killing Of Gram-negative Bacterium Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Immune Effector Process Regulation Of Response To Wounding Negative Regulation Of Coagulation Extracellular Matrix Cell Killing Peptidase Activity Platelet Alpha Granule Lumen Regulation Of Blood Coagulation Regulation Of Hemostasis Defense Response Positive Regulation Of Phagocytosis Azurophil Granule Lumen Positive Regulation Of Platelet Aggregation Endopeptidase Activity IgG Binding Regulation Of Multicellular Organismal Process Endoplasmic Reticulum Lumen Regulation Of Phagocytosis Acute Inflammatory Response To Antigenic Stimulus Response To Stress Response To Other Organism Positive Regulation Of Homotypic Cell-cell Adhesion Fibrinolysis Blood Microparticle Killing Of Cells Of Another Organism Negative Regulation Of Multicellular Organismal Process	Serine-type Endopeptidase Activity Serine-type Peptidase Activity Peptidase Activity Extracellular Matrix Disassembly Secretory Granule Proteolysis Extracellular Region Endopeptidase Activity Hydrolase Activity Extracellular Matrix Organization Extracellular Structure Organization Extracellular Space Protein Metabolic Process Macromolecule Metabolic Process Extracellular Matrix Protein Maturation Protein Processing Amelogenesis Defense Response To Fungus ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Defense Response To Bacterium Response To Fungus Neutrophil-mediated Killing Of Bacterium Glial Cell Development Angiotensin Maturation Protein-containing Complex Localization Response To Yeast Platelet Alpha Granule Protein Catabolic Process Response To Bacterium Neutrophil Mediated Immunity Protein-folding Chaperone Binding Basolateral Plasma Membrane Amyloid-beta Complex Monoatomic Ion Homeostasis Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Monoatomic Cation Homeostasis Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Biofilm Matrix Disassembly Killing By Host Of Symbiont Cells Glycoprotein Catabolic Process Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Positive Regulation Of MAP Kinase Activity Regulation Of Protein Serine/threonine Kinase Activity Myelin Sheath
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