F5 and ELANE

Number of citations of the paper that reports this interaction (PubMedID 9242537)
0

Data Source:
HPRD (in vitro)

		F5	ELANE
Description		coagulation factor V	elastase, neutrophil expressed
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Membrane COPII-coated ER To Golgi Transport Vesicle Platelet Alpha Granule Platelet Alpha Granule Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Extracellular Vesicle	Extracellular Region Extracellular Space Cytoplasm Golgi Apparatus Cytosol Cell Surface Transcription Repressor Complex Secretory Granule Extracellular Matrix Cytoplasmic Vesicle Azurophil Granule Lumen Specific Granule Lumen Phagocytic Vesicle Extracellular Exosome
	Molecular Function	Copper Ion Binding Protein Binding Metal Ion Binding	Protease Binding Transcription Corepressor Activity Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Cytokine Binding
	Biological Process	Blood Coagulation Hemostasis Blood Circulation Response To Vitamin K	Negative Regulation Of Transcription By RNA Polymerase II Response To Yeast Acute Inflammatory Response To Antigenic Stimulus Leukocyte Migration Involved In Inflammatory Response Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Proteolysis Intracellular Calcium Ion Homeostasis Phagocytosis Response To UV Extracellular Matrix Disassembly Protein Catabolic Process Response To Lipopolysaccharide Negative Regulation Of Chemokine Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Interleukin-8 Production Defense Response To Bacterium Positive Regulation Of MAP Kinase Activity Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Positive Regulation Of Immune Response Defense Response To Fungus Leukocyte Migration Negative Regulation Of Chemotaxis Pyroptotic Inflammatory Response Neutrophil-mediated Killing Of Gram-negative Bacterium Neutrophil-mediated Killing Of Fungus Positive Regulation Of Leukocyte Tethering Or Rolling
Pathways		Platelet degranulation Common Pathway of Fibrin Clot Formation COPII-mediated vesicle transport Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cargo concentration in the ER Post-translational protein phosphorylation	Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Pyroptosis Neutrophil degranulation Antimicrobial peptides Regulation of Complement cascade Expression of NOTCH2NL genes
Drugs		Drotrecogin alfa Thrombomodulin Alfa Thrombin Protein C Human thrombin Thrombin alfa Protein S human Anti-inhibitor coagulant complex	Alpha-1-proteinase inhibitor Mdl 101,146 Freselestat Elafin Lupeol Ursolic acid
Diseases		Factor V deficiency; Owren disease Inherited thrombophilia	Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia
GWAS		Activated partial thromboplastin time ( 22703881 29403010) Cytokine network levels (multivariate analysis) ( 31679650) D-dimer levels ( 21502573) D-dimer levels in HIV infection ( 33095540) Hemostatic factors and hematological phenotypes ( 22443383) Hippocampal atrophy ( 22745009) Inflammatory biomarkers (multivariate analysis) ( 33110245) Iron status biomarkers (ferritin levels) ( 33536631) Iron status biomarkers (total iron binding capacity) ( 33536631) Ischemic stroke ( 26732560) Macrovascular complications in type 2 diabetes ( 33430853) Medication use (antithrombotic agents) ( 31015401) Optic disc area ( 31798171 25631615) Optic disc size ( 31809533) Peripheral artery disease ( 31285632) Plasma factor V levels in venous thrombosis ( 31271701) Prothrombin time ( 29403010) Stem cell growth factor beta levels ( 27989323) Thrombosis ( 26908601) Uric acid levels ( 23703922) Venous thromboembolism ( 32232851 33592630 31676865 31420334 28373160 25772935 23650146 22672568 21980494) Vertical cup-disc ratio ( 31798171 28073927) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Blood protein levels ( 30072576)
Interacting Genes		11 interacting genes: CALR CSNK2A1 CTSG ELANE F10 F2 MMRN1 PROC PROS1 SERPINA3 SRPK2	31 interacting genes: ACE2 CAMP CSF3 CSF3R CXCL12 CXCR4 ELN F2R F2RL1 F5 GRN ITGAM KNG1 LPA LRP1 NOTCH2NLA SDC1 SERPINA1 SERPINA3 SERPINB1 SERPINB13 SERPIND1 SERPINE1 SERPINF2 SERPING1 SLPI TFPI TGFA THBS1 VCAM1 YARS1
Entrez ID		2153	1991
HPRD ID		01964	00554
Ensembl ID		ENSG00000198734	ENSG00000197561
Uniprot IDs		P12259	P08246
PDB IDs		1CZS 1CZT 1CZV 3P6Z 3P70 3S9C 7KVE 7KVF 7KXY 7TPP 8FDG 8TN9 9CTH	1B0F 1H1B 1HNE 1PPF 1PPG 2RG3 2Z7F 3Q76 3Q77 4NZL 4WVP 5A09 5A0A 5A0B 5A0C 5A8X 5A8Y 5A8Z 5ABW 6E69 6F5M 6SMA 7CBK 7WHU 8D4Q 8D4U 8D7I 8D7K 8G24 8G25 8G26 8QGX 8VK5 9ASS 9ASX 9ATK 9ATU
Enriched GO Terms of Interacting Partners?		Coagulation Blood Coagulation Hemostasis Serine-type Peptidase Activity Neutrophil-mediated Killing Of Bacterium Leukocyte Mediated Immunity Serine-type Endopeptidase Activity Regulation Of Platelet Activation Acute Inflammatory Response Negative Regulation Of Wound Healing Leukocyte Mediated Cytotoxicity Neutrophil Mediated Immunity Golgi Lumen Regulation Of Body Fluid Levels Killing By Host Of Symbiont Cells Extracellular Region Extracellular Space Calcium Ion Binding Biological Process Involved In Interaction With Symbiont Regulation Of Wound Healing External Side Of Plasma Membrane Neutrophil-mediated Killing Of Gram-negative Bacterium Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Immune Effector Process Regulation Of Response To Wounding Negative Regulation Of Coagulation Extracellular Matrix Cell Killing Peptidase Activity Platelet Alpha Granule Lumen Regulation Of Blood Coagulation Regulation Of Hemostasis Defense Response Positive Regulation Of Phagocytosis Azurophil Granule Lumen Positive Regulation Of Platelet Aggregation Endopeptidase Activity IgG Binding Regulation Of Multicellular Organismal Process Endoplasmic Reticulum Lumen Regulation Of Phagocytosis Acute Inflammatory Response To Antigenic Stimulus Response To Stress Response To Other Organism Positive Regulation Of Homotypic Cell-cell Adhesion Fibrinolysis Blood Microparticle Killing Of Cells Of Another Organism Negative Regulation Of Multicellular Organismal Process	Extracellular Region Peptidase Inhibitor Activity Extracellular Space Serine-type Endopeptidase Inhibitor Activity Endopeptidase Inhibitor Activity Platelet Alpha Granule Lumen Regulation Of Blood Coagulation Regulation Of Hemostasis Regulation Of Body Fluid Levels Circulatory System Process Blood Coagulation Coagulation Hemostasis Regulation Of Response To Wounding Extracellular Exosome Extracellular Matrix Regulation Of Wound Healing Defense Response Blood Circulation Inflammatory Response Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Protease Binding Regulation Of Biological Quality Cell Surface Positive Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Negative Regulation Of Proteolysis Negative Regulation Of Plasminogen Activation Positive Regulation Of Coagulation Regulation Of Multicellular Organismal Process Chronic Inflammatory Response Endoplasmic Reticulum Lumen Positive Regulation Of Vasculature Development Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Fibrinolysis Immune System Process External Side Of Plasma Membrane Positive Regulation Of Cell Population Proliferation Regulation Of Fibrinolysis Regulation Of Plasminogen Activation Regulation Of Proteolysis System Process Positive Regulation Of Interleukin-8 Production Fibrinolysis Signaling Receptor Binding Positive Regulation Of Wound Healing Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Reactive Oxygen Species Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?