SEPTIN10 and LSM8

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SEPTIN10	LSM8
Description		septin 10	LSM8 homolog, U6 small nuclear RNA associated
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Cilium Septin Ring Microtubule Cytoskeleton Septin Complex Motile Cilium Cell Division Site Cell Projection	Nucleus Nucleoplasm Spliceosomal Complex U6 SnRNP U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome Lsm2-8 Complex Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Molecular Adaptor Activity	RNA Binding MRNA Binding Protein Binding U6 SnRNA Binding
	Biological Process	Intracellular Protein Localization Cell Division Cytoskeleton-dependent Cytokinesis	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing
Pathways			mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847)	Anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Glaucoma (primary open-angle) ( 29891935 33627673) Intraocular pressure ( 29617998) Plasma anti-thyroid peroxidase levels ( 29678681) Positive urgency ( 30718321) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Smoking initiation ( 33082346) Smoking status (current vs never) ( 33082346) Triglyceride levels ( 30108155)
Interacting Genes		3 interacting genes: H2AP LSM8 YTHDC1	49 interacting genes: ARNT BCKDK COL23A1 DBF4 DCP1A DCP1B DPAGT1 ECHDC2 EFTUD2 EXOSC10 EXOSC6 FERMT3 GMPPA GTF2I HSPA9 IFNLR1 IGHMBP2 ISOC2 ITSN2 KCTD3 LSM2 LSM3 LSM5 LSM6 LSM7 MAPK8IP2 MGA MINDY1 MPRIP MRPL48 MTHFR NAGK NME4 PDCD2 PGD PHF11 RBM5 RPL24 RSC1A1 RSL24D1 SEPTIN10 SEPTIN5 SMU1 SNRNP200 SNRPB SNRPD1 TALDO1 THUMPD3 UPF1
Entrez ID		151011	51691
HPRD ID		15325	06288
Ensembl ID		ENSG00000186522	ENSG00000128534
Uniprot IDs		B5ME97 B7Z277 B7Z371 E7EW69 Q59H84 Q9H9P7 Q9P0V9	A4D0W0 O95777
PDB IDs			3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 7ABG 8H6E 8H6J 8H6K 8H6L 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5
Enriched GO Terms of Interacting Partners?		Heterochromatin Formation Negative Regulation Of Gene Expression, Epigenetic MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Primary Follicle Stage Mammalian Oogenesis Stage Epigenetic Regulation Of Gene Expression MRNA Binding MRNA Alternative Polyadenylation Lsm2-8 Complex RNA Splicing U6 SnRNP MRNA Processing N6-methyladenosine-containing RNA Reader Activity U6 SnRNA Binding Precatalytic Spliceosome MRNA Metabolic Process Sex-chromosome Dosage Compensation Dosage Compensation By Inactivation Of X Chromosome Chromatin Remodeling MRNA 3'-end Processing MRNA Splice Site Recognition Chromatin Organization U4/U6 X U5 Tri-snRNP Complex RNA Processing U2-type Precatalytic Spliceosome Negative Regulation Of Gene Expression MRNA Export From Nucleus Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Export From Nucleus RNA 3'-end Processing	U2-type Precatalytic Spliceosome U4/U6 X U5 Tri-snRNP Complex Lsm2-8 Complex MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions U6 SnRNP MRNA Catabolic Process Spliceosomal Complex Lsm1-7-Pat1 Complex RNA Catabolic Process RNA Splicing Catalytic Step 2 Spliceosome Nucleobase-containing Compound Metabolic Process RNA Metabolic Process MRNA Processing RNA Processing RNA Binding Ribonucleoprotein Complex Small Nuclear Ribonucleoprotein Complex Precatalytic Spliceosome P-body Nucleobase-containing Compound Catabolic Process Nuclear-transcribed MRNA Catabolic Process Nucleic Acid Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Protein-RNA Complex Assembly Double-stranded DNA Helicase Activity U5 SnRNP Positive Regulation Of MRNA Cis Splicing, Via Spliceosome U12-type Spliceosomal Complex Deadenylation-independent Decapping Of Nuclear-transcribed MRNA U2-type Catalytic Step 2 Spliceosome Spliceosomal Tri-snRNP Complex U1 SnRNP Binding Nucleoplasm Poly(A)-dependent SnoRNA 3'-end Processing 7-methylguanosine Cap Hypermethylation Spliceosomal SnRNP Assembly Regulation Of MRNA Splicing, Via Spliceosome Spliceosomal Complex Assembly Nucleolar Exosome (RNase Complex) 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity Nuclear MRNA Surveillance U4 SnRNP Methylosome Macromolecule Metabolic Process Pentose-phosphate Shunt Regulation Of MRNA Processing Septin Ring
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