SEC22B and B3GAT3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SEC22B	B3GAT3
Description		SEC22 homolog B, vesicle trafficking protein	beta-1,3-glucuronyltransferase 3
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GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Endomembrane System ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Phagocytic Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Melanosome	Golgi Membrane Golgi Apparatus Cis-Golgi Network Membrane Extracellular Exosome
	Molecular Function	SNAP Receptor Activity Protein Binding	Protein Binding Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase Activity Glucuronosyltransferase Activity Transferase Activity Metal Ion Binding Protein Phosphatase Activator Activity
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Protein Transport Vesicle-mediated Transport Positive Regulation Of Protein Catabolic Process Membrane Fusion Negative Regulation Of Autophagosome Assembly	Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Protein Glycosylation Heparan Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of Catalytic Activity Chondroitin Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of Intracellular Protein Transport
Pathways		ER-Phagosome pathway COPII-mediated vesicle transport Cargo concentration in the ER COPI-dependent Golgi-to-ER retrograde traffic	Glycosaminoglycan-protein linkage region biosynthesis Defective B3GAT3 causes JDSSDHD
Drugs			UDP-alpha-D-glucuronic acid Uridine-5'-Diphosphate
Diseases
GWAS		Iris color (L* coordinate) ( 30895295)	Appendicular lean mass ( 33097823) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		57 interacting genes: ABHD16A AIG1 AQP6 B3GAT3 CD79A CERS6 CLDN7 CLRN1 CPLX4 CREB3 CREB3L1 DPM3 EBP ELOVL4 ERGIC3 FAM174A FAM209A FCER1G FNDC9 GJA8 GJB5 GJB6 GORAB GPR152 GPX8 HIBADH HSD17B13 IFNGR2 JAGN1 KIR2DL3 LHFPL1 LHFPL5 LMNA MFF MGST2 MGST3 MMGT1 MRPS18B MUC1 NDUFAF2 REEP4 RELL2 RHBDD1 SERINC2 SLC10A6 SLC35H1 STX1A STX2 STX4 STX5 TLCD4 TM4SF19 TMEM132D TMEM139 TMEM167B TMEM229B TMEM86B	5 interacting genes: CCR2 CCR4 GPR35 HNRNPD SEC22B
Entrez ID		9554	26229
HPRD ID		04939	07564
Ensembl ID		ENSG00000265808	ENSG00000149541
Uniprot IDs		O75396	G3V150 O94766 Q5U676
PDB IDs		2NUP 2NUT 3EGD 3EGX 8HR0	1FGG 1KWS 3CU0
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane SNARE Complex SNARE Binding SNAP Receptor Activity Exocytosis Endoplasmic Reticulum Protein Binding Positive Regulation Of Regulated Secretory Pathway Connexin Complex Gap Junction Channel Activity Secretion By Cell Vesicle Docking Glutathione Peroxidase Activity Gap Junction Leukotriene-C4 Synthase Activity Cornified Envelope Assembly Organelle Localization By Membrane Tethering Gap Junction-mediated Intercellular Transport Positive Regulation Of Exocytosis Membrane Docking Secretion Vesicle Fusion Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Organelle Membrane Fusion Intercellular Transport SNARE Complex Assembly Lipid Metabolic Process Regulation Of Regulated Secretory Pathway Membrane Assembly Organelle Fusion Regulation Of Secretion Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus	Chemokine Receptor Activity Chemokine-mediated Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration C-C Chemokine Binding C-C Chemokine Receptor Activity G Protein-coupled Receptor Activity Cytokine-mediated Signaling Pathway Hepatocyte Dedifferentiation Cellular Response To Putrescine Negative Regulation Of Eosinophil Degranulation Positive Regulation Of Astrocyte Chemotaxis T-helper 17 Cell Chemotaxis Chemokine (C-C Motif) Ligand 12 Binding Chemokine (C-C Motif) Ligand 2 Binding Circadian Regulation Of Translation Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Positive Regulation Of Thymocyte Migration Positive Regulation Of CD8-positive, Alpha-beta T Cell Extravasation Chemokine (C-C Motif) Ligand 7 Binding Positive Regulation Of Hematopoietic Stem Cell Migration Regulation Of Astrocyte Chemotaxis G Protein-coupled Receptor Signaling Pathway Regulation Of Thymocyte Migration Regulation Of Immune Complex Clearance By Monocytes And Macrophages Calcium-mediated Signaling Homeostasis Of Number Of Cells CCR2 Chemokine Receptor Binding Positive Regulation Of T Cell Extravasation Cell Chemotaxis Positive Regulation Of Telomere Capping MCRD-mediated MRNA Stability Complex Positive Regulation Of Monocyte Extravasation Monocyte Extravasation Response To Rapamycin Cell Dedifferentiation Neutrophil Clearance Regulation Of Biological Quality C-X-C Chemokine Receptor Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Response To Sodium Phosphate Minor Groove Of Adenine-thymine-rich DNA Binding Positive Regulation Of Leukocyte Tethering Or Rolling Positive Regulation Of Glutamate Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Chemotaxis CRD-mediated MRNA Stabilization Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Autophagosome Assembly Inflammatory Response To Wounding Positive Regulation Of Glial Cell Migration
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