SEC22B and CERS6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SEC22B	CERS6
Description		SEC22 homolog B, vesicle trafficking protein	ceramide synthase 6
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GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Endomembrane System ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Phagocytic Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Melanosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	SNAP Receptor Activity Protein Binding	DNA Binding Protein Binding Transferase Activity Sphingosine N-acyltransferase Activity
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Protein Transport Vesicle-mediated Transport Positive Regulation Of Protein Catabolic Process Membrane Fusion Negative Regulation Of Autophagosome Assembly	Lipid Metabolic Process Sphingolipid Metabolic Process Inflammatory Response Oligodendrocyte Development Sphingolipid Biosynthetic Process Ceramide Biosynthetic Process Positive Regulation Of Oligodendrocyte Apoptotic Process
Pathways		ER-Phagosome pathway COPII-mediated vesicle transport Cargo concentration in the ER COPI-dependent Golgi-to-ER retrograde traffic	Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Iris color (L* coordinate) ( 30895295)	Bipolar disorder ( 31043756 34002096) Parkinson's disease ( 27182965) Recurrent major depressive disorder ( 34099189) Recurrent major depressive disorder x sex interaction ( 34099189) Red cell distribution width ( 27863252 28957414 32888494) Skin aging (microtopography measurement) ( 28502801) Thyroid stimulating hormone levels ( 32769997) Triglyceride levels ( 32203549)
Interacting Genes		57 interacting genes: ABHD16A AIG1 AQP6 B3GAT3 CD79A CERS6 CLDN7 CLRN1 CPLX4 CREB3 CREB3L1 DPM3 EBP ELOVL4 ERGIC3 FAM174A FAM209A FCER1G FNDC9 GJA8 GJB5 GJB6 GORAB GPR152 GPX8 HIBADH HSD17B13 IFNGR2 JAGN1 KIR2DL3 LHFPL1 LHFPL5 LMNA MFF MGST2 MGST3 MMGT1 MRPS18B MUC1 NDUFAF2 REEP4 RELL2 RHBDD1 SERINC2 SLC10A6 SLC35H1 STX1A STX2 STX4 STX5 TLCD4 TM4SF19 TMEM132D TMEM139 TMEM167B TMEM229B TMEM86B	5 interacting genes: AGTR1 BCL2L13 CERS2 OPRL1 SEC22B
Entrez ID		9554	253782
HPRD ID		04939	17258
Ensembl ID		ENSG00000265808	ENSG00000172292
Uniprot IDs		O75396	Q6ZMG9
PDB IDs		2NUP 2NUT 3EGD 3EGX 8HR0	8QZ6 8QZ7 9EOT
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane SNARE Complex SNARE Binding SNAP Receptor Activity Exocytosis Endoplasmic Reticulum Protein Binding Positive Regulation Of Regulated Secretory Pathway Connexin Complex Gap Junction Channel Activity Secretion By Cell Vesicle Docking Glutathione Peroxidase Activity Gap Junction Leukotriene-C4 Synthase Activity Cornified Envelope Assembly Organelle Localization By Membrane Tethering Gap Junction-mediated Intercellular Transport Positive Regulation Of Exocytosis Membrane Docking Secretion Vesicle Fusion Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Organelle Membrane Fusion Intercellular Transport SNARE Complex Assembly Lipid Metabolic Process Regulation Of Regulated Secretory Pathway Membrane Assembly Organelle Fusion Regulation Of Secretion Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus	Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Calcium-mediated Signaling Angiotensin Type I Receptor Activity Phospholipase C-activating Angiotensin-activated Signaling Pathway Bradykinin Receptor Binding Renin-angiotensin Regulation Of Aldosterone Production Nociceptin Receptor Activity Negative Regulation Of Schwann Cell Proliferation Involved In Axon Regeneration Negative Regulation Of Schwann Cell Migration Angiotensin Type II Receptor Activity Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin G Protein-coupled Opioid Receptor Activity Negative Regulation Of Glial Cell Migration Sphingosine N-acyltransferase Activity Regulation Of Lipid Metabolic Process Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Regulation Of Renal Sodium Excretion Neuron-neuron Synaptic Transmission G Protein-coupled Opioid Receptor Signaling Pathway Negative Regulation Of Autophagosome Assembly Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Negative Regulation Of Axon Regeneration Negative Regulation Of Schwann Cell Proliferation N-acyltransferase Activity Negative Regulation Of Neuron Projection Regeneration G Protein-coupled Receptor Activity Low-density Lipoprotein Particle Remodeling Positive Regulation Of Macrophage Derived Foam Cell Differentiation Angiotensin-activated Signaling Pathway Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Glycolytic Process Through Glucose-6-phosphate Oxidative Phosphorylation Glycolytic Process Through Fructose-6-phosphate Canonical Glycolysis Negative Regulation Of Glial Cell Proliferation Regulation Of Glial Cell Migration
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