CYP4F22 and MSMO1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CYP4F22	MSMO1
Description		cytochrome P450 family 4 subfamily F member 22	methylsterol monooxygenase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane
	Molecular Function	Monooxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Heme Binding Metal Ion Binding	C-4 Methylsterol Oxidase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity
	Biological Process	Lipid Metabolic Process Icosanoid Metabolic Process Ceramide Biosynthetic Process	Lipid Metabolic Process Fatty Acid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Lipid Biosynthetic Process Sterol Biosynthetic Process
Pathways		Fatty acids Miscellaneous substrates Eicosanoids Synthesis of Leukotrienes (LT) and Eoxins (EX) Defective CYP4F22 causes ARCI5	Cholesterol biosynthesis Cholesterol biosynthesis via lathosterol
Drugs			NADH
Diseases		Lamellar ichthyosis (LI) and Non-bullous congenital ichthyosiform erythroderma (NBCIE)
GWAS		Lymphocyte count ( 32888494)	Heel bone mineral density ( 30598549) Neuroticism ( 27067015)
Interacting Genes		4 interacting genes: AQP6 MSMO1 REEP2 TLCD4	19 interacting genes: ATXN1 CHRM5 CYP4F22 DNAJC30 ERG28 GOLT1A GPR35 HMOX1 MARCHF6 MMP14 STRIT1 STX3 TMEM11 TMEM140 TMEM242 TMEM65 TMEM86B VKORC1 YIF1A
Entrez ID		126410	6307
HPRD ID		08256	07396
Ensembl ID		ENSG00000171954	ENSG00000052802
Uniprot IDs		Q6NT55	Q15800
PDB IDs
Enriched GO Terms of Interacting Partners?		PH-gated Chloride Channel Activity Nitrate Transmembrane Transporter Activity Nitrate Transmembrane Transport Taste Receptor Binding Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport C-4 Methylsterol Oxidase Activity Protein Transport Into Membrane Raft Sensory Perception Of Sweet Taste Sensory Perception Of Bitter Taste Monoatomic Anion Channel Activity Ammonium Channel Activity Renal Water Transport Protein Localization To Membrane Raft Ammonium Transmembrane Transport Endoplasmic Reticulum Water Channel Activity Carbon Dioxide Transport Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network One-carbon Compound Transport Water Transport Sensory Perception Of Taste Fluid Transport Cholesterol Biosynthetic Process Channel Activity Sterol Biosynthetic Process Cytoplasmic Microtubule Endoplasmic Reticulum Organization	Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane
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