ZNF558 and EXOSC5

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ZNF558	EXOSC5
Description		zinc finger protein 558	exosome component 5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Euchromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex) Exoribonuclease Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	3'-5'-RNA Exonuclease Activity DNA Binding RNA Binding RNA Exonuclease Activity Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	RRNA Processing RNA Processing RNA Catabolic Process MRNA Catabolic Process RRNA Catabolic Process U4 SnRNA 3'-end Processing DNA Deamination Defense Response To Virus Nuclear MRNA Surveillance Poly(A)-dependent SnoRNA 3'-end Processing
Pathways		Generic Transcription Pathway	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases
GWAS			Appendicular lean mass ( 33097823)
Interacting Genes		13 interacting genes: APOE CLK2 CSNK2A1 EFEMP2 EIF1AD EXOSC5 GSDMD HEXIM2 LZIC MAD2L2 MFAP1 TIAM1 UBTFL1	82 interacting genes: ACOT11 ADAMTSL4 BIRC2 BORCS6 CALCOCO2 CCDC88B CDK5RAP1 CEP55 CPSF7 DAAM2 DDIT4L DHRS2 DIS3 DMRTB1 DOCK8 EFHC2 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FCHO1 FH FHL3 GOLGA2 HOXC4 IKZF3 KCTD13 KIAA1217 KRT13 KRT27 KRT31 KRT34 KRT35 LCA5L LIPG LRMDA LSM3 LSM5 LZTS2 MEOX2 MPHOSPH6 MTMR3 MTREX MYLIP NKAPD1 NMI NUP210 PA2G4 PALS2 PEG10 PICK1 PIH1D2 PKM POLR2L PRDM6 PTEN REL SFPQ SH3GLB1 SH3GLB2 SHISA6 SNW1 SPTA1 TEX11 TFIP11 TLE5 TNFAIP1 TRIB3 TRIM54 TRIM62 YTHDF3 ZFP90 ZMAT1 ZNF420 ZNF558 ZNF620 ZNF655 ZNF792
Entrez ID		148156	56915
HPRD ID		15841	16222
Ensembl ID		ENSG00000167785	ENSG00000077348
Uniprot IDs		Q96NG5	Q9NQT4
PDB IDs			2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Phospholipid Efflux Artery Development Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Negative Regulation Of DNA Repair Negative Regulation Of DNA Recombination Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Double-strand Break Repair Microfibril DNA Damage Response, Signal Transduction Resulting In Transcription Positive Regulation Of Smooth Muscle Cell-matrix Adhesion Negative Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Cell Cycle Process Positive Regulation Of Presynaptic Membrane Organization Chylomicron Remnant Lipid Transport Involved In Lipid Storage Lipoprotein Particle Positive Regulation Of Neurofibrillary Tangle Assembly Discoidal High-density Lipoprotein Particle Regulation Of Chromosome Separation Positive Regulation Of Aortic Smooth Muscle Cell Differentiation	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Nucleolar Exosome (RNase Complex) RNA Exonuclease Activity Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process U4 SnRNA 3'-end Processing RRNA 3'-end Processing TRNA Decay Nuclear MRNA Surveillance Nuclear RNA Surveillance RNA Surveillance RRNA Processing SnRNA Metabolic Process RRNA Metabolic Process RNA 3'-end Processing RNA Processing SnRNA 3'-end Processing CUT Catabolic Process RNA Catabolic Process 3'-5'-RNA Exonuclease Activity RRNA Catabolic Process SnRNA Processing MRNA Catabolic Process Poly(A)-dependent SnoRNA 3'-end Processing MRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Nucleobase-containing Compound Catabolic Process RNA Metabolic Process Sno(s)RNA Metabolic Process Exoribonuclease Complex TRNA Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Structural Constituent Of Skin Epidermis Cytosol Intermediate Filament Organization Nucleic Acid Metabolic Process RNA Binding Macromolecule Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Nucleolus Positive Regulation Of Protein K48-linked Ubiquitination Positive Regulation Of Protein Polyubiquitination
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