ZNF558 and GSDMD

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZNF558	GSDMD
Description		zinc finger protein 558	gasdermin D
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane Mitochondrial Membrane Specific Granule Lumen Canonical Inflammasome Complex NLRP3 Inflammasome Complex Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Phosphatidylserine Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Lipid Binding Wide Pore Channel Activity Phosphatidylinositol-4-phosphate Binding Phosphatidic Acid Binding Cardiolipin Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	Plasma Membrane Repair Immune System Process Inflammatory Response Protein Secretion Programmed Cell Death Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Positive Regulation Of Interleukin-18 Production Interleukin-18-mediated Signaling Pathway Defense Response To Bacterium NLRP3 Inflammasome Complex Assembly Innate Immune Response Ceramide Biosynthetic Process Pore Complex Assembly Positive Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Protein Homooligomerization Protein Maturation Transmembrane Transport Pyroptotic Inflammatory Response Interleukin-1-mediated Signaling Pathway Pyroptotic Cell Death
Pathways		Generic Transcription Pathway	Release of apoptotic factors from the mitochondria Interleukin-1 processing Pyroptosis Regulation of TLR by endogenous ligand Neutrophil degranulation Purinergic signaling in leishmaniasis infection CASP4-mediated substrate cleavage CASP5-mediated substrate cleavage
Drugs
Diseases
GWAS			Alanine aminotransferase levels ( 33547301) Monocyte count ( 32888494) Schizophrenia ( 31268507)
Interacting Genes		13 interacting genes: APOE CLK2 CSNK2A1 EFEMP2 EIF1AD EXOSC5 GSDMD HEXIM2 LZIC MAD2L2 MFAP1 TIAM1 UBTFL1	9 interacting genes: ASPG CASP1 KCTD6 MEOX2 MFHAS1 PSMA1 ZBTB33 ZNF426 ZNF558
Entrez ID		148156	79792
HPRD ID		15841	11014
Ensembl ID		ENSG00000167785	ENSG00000104518
Uniprot IDs		Q96NG5	P57764
PDB IDs			5NH1 5WQT 6AO4 6KN0 6N9O 6VFE 7Z1X
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Phospholipid Efflux Artery Development Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Negative Regulation Of DNA Repair Negative Regulation Of DNA Recombination Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Double-strand Break Repair Microfibril DNA Damage Response, Signal Transduction Resulting In Transcription Positive Regulation Of Smooth Muscle Cell-matrix Adhesion Negative Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Cell Cycle Process Positive Regulation Of Presynaptic Membrane Organization Chylomicron Remnant Lipid Transport Involved In Lipid Storage Lipoprotein Particle Positive Regulation Of Neurofibrillary Tangle Assembly Discoidal High-density Lipoprotein Particle Regulation Of Chromosome Separation Positive Regulation Of Aortic Smooth Muscle Cell Differentiation
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