AZI2 and N4BP1

Number of citations: 55 (PubMedID 21903422)
Data Source: BioGRID (pull down)

		AZI2	N4BP1
Name		5-azacytidine induced 2	NEDD4 binding protein 1
Structure
GO Annotations	Cellular Component	Cytoplasm Serine/threonine Protein Kinase Complex	Nucleus Nucleolus Cytoplasm Cytosol PML Body
	Molecular Function	Protein Binding	RNA Binding MRNA Binding Nuclease Activity RNA Nuclease Activity Protein Binding Hydrolase Activity Ubiquitin Binding
	Biological Process	Mitotic Cell Cycle T Cell Activation Negative Regulation Of Canonical NF-kappaB Signal Transduction Dendritic Cell Proliferation Defense Response To Virus Type I Interferon-mediated Signaling Pathway Dendritic Cell Differentiation	Negative Regulation Of Cytokine Production Immune System Process Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To UV Negative Regulation Of Viral Genome Replication Innate Immune Response Regulation Of Innate Immune Response
Pathways		None	Regulation of NF-kappa B signaling
GWAS		Cognitive decline (age-related) ( 28078323 )	Eosinophil count ( 27863252 32888494 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 27863252 32888494 ) Neutrophil percentage of granulocytes ( 27863252 ) Serum metabolite levels ( 33031748 ) Social autistic-like traits ( 24133439 ) Sum eosinophil basophil counts ( 27863252 )
Interacting Genes		16 interacting genes: APBA3 FAM107A GABARAP GABARAPL1 GABARAPL2 IKBKE MIB1 MTPAP N4BP1 RB1CC1 RNF31 TAX1BP1 TBK1 TICAM1 TRAF3 TXLNA	8 interacting genes: AZI2 CDK6 ITCH LITAF LSM1 MID1 NEDD8 UBC
Entrez ID		64343	9683
HPRD ID		10577	Not available
Ensembl ID		ENSG00000163512	ENSG00000102921
Uniprot IDs		Q9H6S1	O75113
PDB IDs		5EP6 5Z7G 5Z7L 7EA2 7EA7	6Q3V
GO Terms Enriched among Interactors		Autophagosome Cell Surface Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cellular Response To Nitrogen Starvation Ubiquitin Protein Ligase Binding Regulation Of Canonical NF-kappaB Signal Transduction Cell Surface Pattern Recognition Receptor Signaling Pathway Autophagy Autophagosome Membrane Macroautophagy Phosphatidylethanolamine Binding GABA Receptor Binding Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Cytoplasm Autophagy Of Mitochondrion Serine/threonine Protein Kinase Complex Activation Of Innate Immune Response Positive Regulation Of Type I Interferon Production Activation Of Immune Response Autophagosome Assembly Regulation Of Innate Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Defense Response Autophagosome Organization Response To Other Organism Cellular Response To Nutrient Levels Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Defense Response Defense Response To Virus Regulation Of Type I Interferon Production Positive Regulation Of Innate Immune Response Beta-tubulin Binding Response To External Biotic Stimulus Defense Response Regulation Of Immune Response Immune System Process Response To Stress Immune Response-activating Signaling Pathway Autophagosome Maturation Pattern Recognition Receptor Signaling Pathway Type I Interferon-mediated Signaling Pathway Innate Immune Response Vacuole Organization Positive Regulation Of Autophagy Positive Regulation Of Immune Response Innate Immune Response-activating Signaling Pathway Cell Surface Receptor Signaling Pathway Mitophagy Regulation Of Interferon-beta Production Response To Virus	Regulation Of Hematopoietic Stem Cell Differentiation Protein Tag Activity Regulation Of Hematopoietic Progenitor Cell Differentiation T Cell Activation Ubiquitin Protein Ligase Binding Endosome Membrane Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Stem Cell Differentiation Response To Virus Cytoplasm Cyclin D3-CDK6 Complex Lymphocyte Activation Cyclin D1-CDK6 Complex Cyclin D2-CDK6 Complex FBXO Family Protein Binding Macromolecule Catabolic Process Cytoplasmic Side Of Late Endosome Membrane Negative Regulation Of Canonical NF-kappaB Signal Transduction Gliogenesis Negative Regulation Of Monocyte Differentiation Leukocyte Activation Cell Dedifferentiation Cell Activation Response To External Biotic Stimulus Cellular Response To Camptothecin Protein Ubiquitination Modification-dependent Protein Catabolic Process Cytoplasmic Side Of Early Endosome Membrane Lsm1-7-Pat1 Complex Dendritic Cell Proliferation Leukocyte Proliferation Mononuclear Cell Proliferation Positive Regulation Of T Cell Anergy CXCL12-activated CXCR4 Signaling Pathway T Cell Tolerance Induction T Cell Anergy Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation C-X-C Chemokine Receptor CXCR4 Signaling Pathway Early Endosome Membrane Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway Regulation Of T Cell Anergy Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Receptor Catabolic Process CD4-positive, Alpha-beta T Cell Proliferation Arrestin Family Protein Binding Positive Regulation Of T Cell Tolerance Induction Lateral Ventricle Development Type B Pancreatic Cell Development Post-translational Protein Modification