ENTR1 and NOD2

Number of citations of the paper that reports this interaction (PubMedID 27812135)
77

Data Source:
BioGRID (fluorescent resonance energy transfer)

		ENTR1	NOD2
Description		endosome associated trafficking regulator 1	nucleotide binding oligomerization domain containing 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Centrosome Cytoskeleton Midbody Retromer Complex Ciliary Basal Body Cell Projection Recycling Endosome	Cytoplasm Mitochondrion Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Extrinsic Component Of Plasma Membrane Vesicle Protein-containing Complex Phagocytic Vesicle
	Molecular Function	Protein Binding	Nucleotide Binding Actin Binding Protein Binding ATP Binding Enzyme Binding Protein Kinase Binding Hsp70 Protein Binding Muramyl Dipeptide Binding Pattern Recognition Receptor Activity Peptidoglycan Binding Ubiquitin Binding Anion Binding ADP Binding Protein-containing Complex Binding CARD Domain Binding Hsp90 Protein Binding Carbohydrate Derivative Binding
	Biological Process	Protein Transport Cell Projection Organization Endocytic Recycling Regulation Of Cytokinesis Positive Regulation Of Cilium Assembly Cell Division Positive Regulation Of Protein Localization To Cilium	Temperature Homeostasis Pattern Recognition Receptor Signaling Pathway Adaptive Immune Response Immune System Process Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Dendritic Cell Cytokine Production Positive Regulation Of Type 2 Immune Response Autophagy Defense Response Canonical NF-kappaB Signal Transduction Response To Nutrient Positive Regulation Of Cell Population Proliferation Detection Of Biotic Stimulus Detection Of Bacterium Maintenance Of Gastrointestinal Epithelium Regulation Of Appetite Response To Muramyl Dipeptide Detection Of Muramyl Dipeptide Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Stress-activated MAPK Cascade Intracellular Signal Transduction Intestinal Stem Cell Homeostasis P38MAPK Cascade Defense Response To Bacterium Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Innate Immune Response Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Regulation Of Gamma-delta T Cell Activation Host-mediated Modulation Of Intestinal Microbiota Composition Positive Regulation Of Epithelial Cell Proliferation Regulation Of Inflammatory Response Positive Regulation Of B Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of ERK1 And ERK2 Cascade Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein K63-linked Ubiquitination Cellular Response To Lipopolysaccharide Cellular Response To Peptidoglycan Cellular Response To Muramyl Dipeptide Protein Linear Polyubiquitination Antibacterial Innate Immune Response Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Mitophagy Positive Regulation Of Protein K63-linked Ubiquitination Negative Regulation Of Macrophage Apoptotic Process
Pathways			NOD1/2 Signaling Pathway NOD1/2 Signaling Pathway TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Ovarian tumor domain proteases Interleukin-1 signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs			Mifamurtide
Diseases			Crohn's disease Blau syndrome
GWAS			Asthma ( 32296059 31361310 30929738) Asthma (childhood onset) ( 31036433 30929738) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 17804789 28067908 23128233 22936669 22412388 21102463 20570966 18587394 17554300) Inflammatory bowel disease ( 28067908 18758464) Leprosy ( 25642632 27976721 20018961) Medication use (thyroid preparations) ( 31015401) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pediatric autoimmune diseases ( 26301688)
Interacting Genes		12 interacting genes: AP1M1 APP AXIN1 CD99 CHD3 CSNK1E DDX6 GIT1 NOD2 SDCBP SMURF1 VIM	38 interacting genes: ALPI ANKHD1 ANXA2 ATG16L1 C10orf67 CCL13 CHMP4B CHMP5 DCTN1 DOCK7 ENTR1 ERBIN GOLGA6L5P GOLGB1 HAP1 IKBIP IRGM LDOC1 LMNA LURAP1L MAP3K7 NLRC4 PDLIM5 PPP1R12C PPP2R3B PRR16 RIPK2 RPL13A SCYL1 TACC3 TNIP1 TPM1 TPM3 TPM4 TRIM41 VCP WBP11 XIAP
Entrez ID		10807	64127
HPRD ID		15307	05810
Ensembl ID		ENSG00000165689	ENSG00000167207
Uniprot IDs		Q96C92	A0A286YF65 Q9HC29
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Catabolic Process Positive Regulation Of JNK Cascade Regulation Of JNK Cascade Positive Regulation Of Proteolysis Cellular Response To Muramyl Dipeptide Regulation Of Interleukin-1 Beta Production Positive Regulation Of Metabolic Process Regulation Of Interleukin-1 Production Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process I-SMAD Binding Regulation Of Primary Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Proteolysis Growth Cone Protein Serine/threonine Kinase Binding Positive Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Focal Adhesion Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Muramyl Dipeptide R-SMAD Binding Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Lipopolysaccharide Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Cellular Localization Frizzled Binding Negative Regulation Of Cell Communication Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Differentiation Cytosol Cellular Response To Molecule Of Bacterial Origin Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Catabolic Process Cytoplasm Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Protein Domain Specific Binding Amyloid-beta Complex Regulation Of Canonical Wnt Signaling Pathway Regulation Of Amyloid Precursor Protein Catabolic Process Growth Cone Lamellipodium Plasma Membrane Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding	Response To Muramyl Dipeptide Cellular Response To Muramyl Dipeptide Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Muscle Thin Filament Tropomyosin Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Nuclear Migration Response To External Biotic Stimulus Nucleus Localization Stress Fiber Cytosol Pattern Recognition Receptor Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Regulation Of Mitotic Spindle Organization Cellular Response To Lipopolysaccharide Innate Immune Response-activating Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction Autophagy Autophagosome Maturation Cellular Response To Molecule Of Bacterial Origin C-terminal Protein Lipidation Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Activation Of Innate Immune Response Autophagosome Membrane Intracellular Transport Canonical NF-kappaB Signal Transduction P38MAPK Cascade Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Protein Deubiquitination Regulation Of Organelle Organization Vesicle Budding From Membrane Response To Lipid Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Positive Regulation Of Defense Response Positive Regulation Of Protein Metabolic Process Organelle Localization Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Defense Response Protein Linear Polyubiquitination Xenophagy Identical Protein Binding Regulation Of Protein Metabolic Process Cellular Localization Endosome Transport Via Multivesicular Body Sorting Pathway Establishment Of Localization In Cell Cellular Response To Oxygen-containing Compound Positive Regulation Of Xenophagy Positive Regulation Of Organelle Organization
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