ENTR1 and DDX6

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		ENTR1	DDX6
Description		endosome associated trafficking regulator 1	DEAD-box helicase 6
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Centrosome Cytoskeleton Midbody Retromer Complex Ciliary Basal Body Cell Projection Recycling Endosome	Heterochromatin P-body Outer Dense Fiber Nucleus Cytoplasm Cytosol Plasma Membrane Adherens Junction Cytoplasmic Stress Granule Membrane RISC Complex Chromatoid Body Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm Concave Side Of Sperm Head Sperm Annulus
	Molecular Function	Protein Binding	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity MRNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Protein Domain Specific Binding Cadherin Binding
	Biological Process	Protein Transport Cell Projection Organization Endocytic Recycling Regulation Of Cytokinesis Positive Regulation Of Cilium Assembly Cell Division Positive Regulation Of Protein Localization To Cilium	Spermatogenesis Negative Regulation Of Translation Viral RNA Genome Packaging Stem Cell Population Maintenance Neuron Differentiation P-body Assembly Stress Granule Assembly MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Neuron Differentiation Spermatid Differentiation
Pathways			mRNA decay by 5' to 3' exoribonuclease
Drugs			D-tartaric acid
Diseases
GWAS			Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergy ( 27182965) Asthma ( 34103634 30929738 31619474 31959851) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Autoimmune traits (pleiotropy) ( 30572963) Blood protein levels ( 30072576) Celiac disease ( 22057235) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Diffuse cutaneous systemic sclerosis ( 24387989) Height ( 25429064) Hip minimal joint space width ( 27701424) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Non-albumin protein levels ( 29403010) Primary biliary cholangitis ( 28425483) Primary biliary cirrhosis ( 22961000) Refractive error ( 32231278) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Systemic lupus erythematosus ( 19838195 28714469) Systemic sclerosis ( 31672989 24387989) Vitiligo ( 22951725)
Interacting Genes		12 interacting genes: AP1M1 APP AXIN1 CD99 CHD3 CSNK1E DDX6 GIT1 NOD2 SDCBP SMURF1 VIM	75 interacting genes: BEGAIN BEND7 BIRC7 CALCOCO2 CCDC136 CCDC14 CEBPA CEP70 CEP76 CNKSR3 CNOT1 DDX17 DES DISC1 DNAAF11 EDC3 EFHC2 ENTR1 FCHO1 GOLGA2 GPRASP3 HOOK2 IK IKZF1 INKA1 JAKMIP1 JUP KLC4 KRT34 KRT40 KRTAP10-3 KRTAP10-8 LZTS1 MAGED1 MESD MTUS2 NAB2 NONO PAK5 PDLIM7 PICK1 PNMA5 POU6F2 PRDM16 PRPH RAPGEF3 RBM11 RBM14 REL RO60 RUNDC3A SCYL1 SHMT1 SLAIN1 SORBS3 SPATA6 SRPK2 STAT1 TCF12 TCF4 TLE5 TP53BP2 TRAF2 TRIM27 TRIM37 TRIM54 U2AF2 USH1G VPS52 ZBTB10 ZBTB14 ZBTB43 ZBTB8A ZC2HC1C ZNF24
Entrez ID		10807	1656
HPRD ID		15307	02638
Ensembl ID		ENSG00000165689	ENSG00000110367
Uniprot IDs		Q96C92	B2R858 P26196
PDB IDs			1VEC 2WAX 2WAY 4CRW 4CT4 4CT5 5ANR 6F9S 6S8S
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Catabolic Process Positive Regulation Of JNK Cascade Regulation Of JNK Cascade Positive Regulation Of Proteolysis Cellular Response To Muramyl Dipeptide Regulation Of Interleukin-1 Beta Production Positive Regulation Of Metabolic Process Regulation Of Interleukin-1 Production Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process I-SMAD Binding Regulation Of Primary Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Proteolysis Growth Cone Protein Serine/threonine Kinase Binding Positive Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Focal Adhesion Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Muramyl Dipeptide R-SMAD Binding Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Lipopolysaccharide Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Cellular Localization Frizzled Binding Negative Regulation Of Cell Communication Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Differentiation Cytosol Cellular Response To Molecule Of Bacterial Origin Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Catabolic Process Cytoplasm Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Protein Domain Specific Binding Amyloid-beta Complex Regulation Of Canonical Wnt Signaling Pathway Regulation Of Amyloid Precursor Protein Catabolic Process Growth Cone Lamellipodium Plasma Membrane Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding	Cytoskeleton Identical Protein Binding Protein Binding Intermediate Filament Cytoplasm Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Microtubule Nuclear Speck Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Centriole Replication Transcription Coactivator Activity Intermediate Filament Organization Regulation Of MRNA Processing Regulation Of RNA Metabolic Process Cytosol Negative Regulation Of Centriole Replication Aggresome Tumor Necrosis Factor Receptor Binding Negative Regulation Of Metabolic Process Regulation Of Cytoskeleton Organization Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Regulation Of Organelle Organization Regulation Of MRNA Metabolic Process Centrosome Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Keratin Filament
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