TMEM120B and TLCD4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM120B	TLCD4
Description		transmembrane protein 120B	TLC domain containing 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Inner Membrane Membrane	Endoplasmic Reticulum Membrane
	Molecular Function	Monoatomic Ion Channel Activity Protein Binding	Protein Binding
	Biological Process	Fat Cell Differentiation Protein Heterooligomerization	Lipid Homeostasis
Pathways
Drugs
Diseases
GWAS		HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 24026423 27863252 32888494) Mean reticulocyte volume ( 32888494) Molybdenum levels ( 26025379) Neutrophil count ( 32888494) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) White blood cell count ( 32888494)
Interacting Genes		59 interacting genes: ALOX5AP ANKS6 APOA5 AQP6 AQP8 ARL13B BNIP3L CCNDBP1 CD74 COMT CPLX4 CREB3L1 EBP ERGIC3 FCER1G FFAR2 FKBP7 GAD2 GJB1 GORAB GPR152 GPRC5D GPX8 HSD17B11 HSD17B13 IFNGR2 IL7R JAGN1 JPH1 KCNJ6 LMNA LRRTM2 MGST3 MRPS18B MUC1 NCAPH2 REEP2 REEP4 RETREG3 RNF19B RNF5 SCN3B SH3GL3 SLC10A1 SLC10A6 SLC17A8 SLC18A1 SLC1A3 SLC35H1 STOM STX2 TLCD4 TMEM139 TMEM143 TMEM14B TMEM80 TMPRSS2 TMX2 ZDHHC15	72 interacting genes: ADGRB3 ADGRE2 ARV1 ATP13A1 BNIP3 CACNG1 CCDC167 CDIPT CFTR CHPT1 CLCN7 CLEC7A CMTM5 COMT CTXN3 CXCL16 CYP4F2 CYP4F22 DHRSX EBP EMC6 EMP1 ERG28 FA2H FDFT1 FXYD6 FXYD6-FXYD2 GJB2 GOSR2 GYPA HMOX1 IGFBP5 KRT1 LNPEP MS4A13 MYG1 NAT8 NDUFA3 NINJ1 NKG7 ORMDL1 PMP22 PRAF2 PRRT2 REEP6 SCAMP5 SCD SEC22A SEC22B SERP1 SFXN1 SFXN3 SLC41A1 SLC67A1 SMAGP STATH STX12 SYNDIG1 SYNJ2BP TIMM23 TMEM115 TMEM120B TMEM19 TMEM229B TMEM237 TMEM60 TMIE TVP23B UBE2J1 VEZT YIPF1 YIPF4
Entrez ID		144404	148534
HPRD ID		19119	08110
Ensembl ID		ENSG00000188735	ENSG00000152078
Uniprot IDs		A0PK00	Q96MV1
PDB IDs		7F73
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Protein Binding Organic Hydroxy Compound Transport Steroid Dehydrogenase Activity Glutathione Peroxidase Activity Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Organization Leukotriene-C4 Synthase Activity Bile Acid:sodium Symporter Activity Transmembrane Transport Monoamine Transport Leukocyte Mediated Immunity Gamma-aminobutyric Acid Biosynthetic Process Prostanoid Metabolic Process Neurotransmitter Loading Into Synaptic Vesicle Regulation Of Transport Norepinephrine Transport Gamma-aminobutyric Acid Metabolic Process Icosanoid Metabolic Process Ammonium Channel Activity Neurotransmitter Transport Symporter Activity Icosanoid Biosynthetic Process Ammonium Transmembrane Transport Cellular Response To Cocaine Cellular Detoxification Negative Regulation Of Peptide Secretion Amine Transport Cytokine Receptor Activity Serotonin Transport L-glutamate Transmembrane Transporter Activity Lymphocyte Mediated Immunity Non-motile Cilium Assembly Nuclear Envelope Water Channel Activity Negative Regulation Of Leukocyte Apoptotic Process	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Sterol Biosynthetic Process Lipid Biosynthetic Process Cholesterol Biosynthetic Process SNAP Receptor Activity Steroid Biosynthetic Process Membrane Fusion Serine Import Into Mitochondrion Lipid Metabolic Process Sterol Metabolic Process Cholesterol Transport Establishment Of Protein Localization Sterol Transport Membrane Organization Organic Cation Transport Import Into The Mitochondrion Protein Transport L-serine Transmembrane Transporter Activity L-serine Transport Protein Binding Bleb Assembly Serine Transport Vesicle Fusion
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