TMEM120B and AQP8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM120B	AQP8
Description		transmembrane protein 120B	aquaporin 8
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Inner Membrane Membrane	Mitochondrion Mitochondrial Inner Membrane Endoplasmic Reticulum Smooth Endoplasmic Reticulum Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Smooth Endoplasmic Reticulum Membrane Brush Border Membrane Mitochondrial Membrane Apical Part Of Cell Intracellular Canaliculus Intracellular Vesicle
	Molecular Function	Monoatomic Ion Channel Activity Protein Binding	Protein Binding Ammonium Channel Activity Water Channel Activity Methylammonium Channel Activity Urea Channel Activity Channel Activity
	Biological Process	Fat Cell Differentiation Protein Heterooligomerization	Water Transport Urea Transport Methylammonium Transport One-carbon Compound Transport B Cell Differentiation Transepithelial Water Transport Regulation Of Cholesterol Biosynthetic Process Transmembrane Transport Cellular Response To CAMP Urea Transmembrane Transport Ammonium Transmembrane Transport Methylammonium Transmembrane Transport Hydrogen Peroxide Transmembrane Transport Ammonium Import Across Plasma Membrane Cellular Detoxification
Pathways			Detoxification of Reactive Oxygen Species Passive transport by Aquaporins Developmental Lineage of Pancreatic Acinar Cells
Drugs
Diseases
GWAS		HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 24026423 27863252 32888494) Mean reticulocyte volume ( 32888494) Molybdenum levels ( 26025379) Neutrophil count ( 32888494) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) White blood cell count ( 32888494)	Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 27400856)
Interacting Genes		59 interacting genes: ALOX5AP ANKS6 APOA5 AQP6 AQP8 ARL13B BNIP3L CCNDBP1 CD74 COMT CPLX4 CREB3L1 EBP ERGIC3 FCER1G FFAR2 FKBP7 GAD2 GJB1 GORAB GPR152 GPRC5D GPX8 HSD17B11 HSD17B13 IFNGR2 IL7R JAGN1 JPH1 KCNJ6 LMNA LRRTM2 MGST3 MRPS18B MUC1 NCAPH2 REEP2 REEP4 RETREG3 RNF19B RNF5 SCN3B SH3GL3 SLC10A1 SLC10A6 SLC17A8 SLC18A1 SLC1A3 SLC35H1 STOM STX2 TLCD4 TMEM139 TMEM143 TMEM14B TMEM80 TMPRSS2 TMX2 ZDHHC15	6 interacting genes: CYBC1 PLP2 PLPP6 SERP1 STX12 TMEM120B
Entrez ID		144404	343
HPRD ID		19119	04778
Ensembl ID		ENSG00000188735	ENSG00000103375
Uniprot IDs		A0PK00	O94778
PDB IDs		7F73
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Protein Binding Organic Hydroxy Compound Transport Steroid Dehydrogenase Activity Glutathione Peroxidase Activity Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Organization Leukotriene-C4 Synthase Activity Bile Acid:sodium Symporter Activity Transmembrane Transport Monoamine Transport Leukocyte Mediated Immunity Gamma-aminobutyric Acid Biosynthetic Process Prostanoid Metabolic Process Neurotransmitter Loading Into Synaptic Vesicle Regulation Of Transport Norepinephrine Transport Gamma-aminobutyric Acid Metabolic Process Icosanoid Metabolic Process Ammonium Channel Activity Neurotransmitter Transport Symporter Activity Icosanoid Biosynthetic Process Ammonium Transmembrane Transport Cellular Response To Cocaine Cellular Detoxification Negative Regulation Of Peptide Secretion Amine Transport Cytokine Receptor Activity Serotonin Transport L-glutamate Transmembrane Transporter Activity Lymphocyte Mediated Immunity Non-motile Cilium Assembly Nuclear Envelope Water Channel Activity Negative Regulation Of Leukocyte Apoptotic Process	Endoplasmic Reticulum Membrane Nuclear Inner Membrane Isoprenoid Diphosphate Phosphatase Activity Farnesyl Diphosphate Catabolic Process Geranylgeranyl Diphosphate Catabolic Process Endoplasmic Reticulum Geranyl Diphosphate Metabolic Process Positive Regulation Of Neutrophil Activation Chemokine Binding Postsynaptic Recycling Endosome Muscle Organ Morphogenesis Positive Regulation Of Growth Hormone Secretion Respiratory Burst Involved In Defense Response Respiratory Burst After Phagocytosis Lipid Phosphatase Activity Farnesyl Diphosphate Metabolic Process Sphingosine-1-phosphate Phosphatase Activity Protein Prenylation Lysophosphatidic Acid Phosphatase Activity Regulation Of Neutrophil Activation Monoatomic Ion Transmembrane Transporter Activity Membrane Regulation Of Growth Hormone Secretion Phosphatidate Phosphatase Activity
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