SYT9 and CSNK1A1

Number of citations of the paper that reports this interaction (PMID 12062430)
3

Data Source:
HPRD (in vitro)

		SYT9	CSNK1A1
Gene Name		synaptotagmin IX	casein kinase 1, alpha 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Membrane Cell Junction Secretory Granule Membrane Synaptic Vesicle Membrane Dense Core Granule	Condensed Chromosome Kinetochore Cytoplasm Centrosome Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex Membrane Nuclear Speck Primary Cilium
	Molecular Function	Transporter Activity Identical Protein Binding Metal Ion Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Transport Positive Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Insulin Secretion	Protein Phosphorylation Phagocytosis Mitotic Nuclear Division Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cell Shape Wnt Signaling Pathway Peptidyl-serine Phosphorylation Cell Division Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways			Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin APC truncation mutants have impaired AXIN binding T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex RNF mutants show enhanced WNT signaling and proliferation AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated Hedgehog 'on' state XAV939 inhibits tankyrase, stabilizing AXIN Beta-catenin phosphorylation cascade truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated deletions in the AMER1 gene destabilize the destruction complex TCF dependent signaling in response to WNT AMER1 mutants destabilize the destruction complex deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by Hedgehog Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Degradation of GLI2 by the proteasome Activation of SMO
Drugs
Diseases
GWAS		Phospholipid levels (plasma) ( 22359512)	Esophageal cancer ( 21642993)
Protein-Protein Interactions		6 interactors: CSNK1A1 NRXN1 SNAP25 SYNCRIP TRPV1 TUBB	43 interactors: ACTB ADAP1 AP3B1 AP3B2 APC AXIN1 BID CDC25A CHRM3 CREM CTNNB1 EIF2B5 ERF FADD GLI3 GNB2 HMGB1 HMGB2 HNRNPC HSPA4 KPNA2 KPNB1 LGALS3 MAPT MDM4 NFATC3 PARK2 PDE4D PHLPP1 PPP1CC PPP1R14A PPP2R5A PSEN2 RCC1 SLC18A2 SNCA SYT9 TGFBR1 TIAM1 TNFRSF1B TP53 YWHAQ YWHAZ
Entrez ID		143425	1452
HPRD ID		11618	02739
Ensembl ID		ENSG00000170743	ENSG00000113712
Uniprot IDs		Q86SS6	B4DER9 P48729 Q6PJ06 Q71TU5
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Complex Assembly Involved In Synapse Maturation Gamma-aminobutyric Acid Receptor Clustering Neurotransmitter Secretion Positive Regulation Of Synaptic Transmission Guanylate Kinase-associated Protein Clustering Neuroligin Clustering Regulation Of Neurotransmitter Levels Neurotransmitter Transport Gephyrin Clustering Synaptic Vesicle Clustering Thermoception Neuronal Signal Transduction Regulation Of Insulin Secretion Vesicle Localization N-methyl-D-aspartate Receptor Clustering Vocal Learning CRD-mediated MRNA Stabilization Regulation Of Peptide Hormone Secretion Negative Regulation Of Filopodium Assembly Postsynaptic Membrane Assembly Protein Complex Assembly Synapse Maturation Regulation Of Grooming Behavior Regulation Of Hormone Secretion Transport Synaptic Vesicle Docking Presynaptic Membrane Assembly Postsynaptic Density Protein 95 Clustering Synaptic Vesicle Priming Cellular Response To ATP Receptor Localization To Synapse Regulation Of Synaptic Transmission Presynaptic Membrane Organization Auditory Behavior Synaptic Vesicle Fusion To Presynaptic Membrane Cellular Protein Complex Assembly Neurotransmitter Uptake Cerebellar Granule Cell Differentiation Vocalization Behavior Prepulse Inhibition Neuron Cell-cell Adhesion Regulation Of Protein Secretion Chemosensory Behavior Positive Regulation Of Synapse Maturation Mechanosensory Behavior Cerebellar Granular Layer Morphogenesis Organelle Localization Cell Division Response To Auditory Stimulus Regulation Of Synapse Maturation	Death Apoptotic Process Programmed Cell Death Cell Death Cellular Response To Stimulus Regulation Of Cellular Localization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Signaling Positive Regulation Of Cell Death Response To Organic Substance Response To Stimulus Cell Communication Regulation Of Apoptotic Process Response To Stress Regulation Of Cell Death Regulation Of Protein Localization Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Regulation Of Cellular Process Regulation Of Signaling Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Intracellular Transport Execution Phase Of Apoptosis Response To External Stimulus Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cell Death Immune System Process Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Cell Activation Regulation Of Establishment Of Protein Localization Developmental Process Thymus Development Regulation Of Catalytic Activity Signal Transduction Cellular Response To Organic Substance Positive Regulation Of Metabolic Process Positive Regulation Of Mitochondrion Organization Regulation Of Protein Metabolic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway T Cell Differentiation In Thymus Regulation Of Cellular Component Organization Regulation Of Protein Complex Assembly Regulation Of Cellular Protein Metabolic Process Leukocyte Activation Positive Regulation Of Protein Metabolic Process Movement Of Cell Or Subcellular Component
Tagcloud ?			aberrantly antagonistic beauty becomes canonical concert connectivity ctnnb1 decipher discover facts functioning gbm gli2 hedgehog imperative integrative interplay missed ranked recapitulate relying shh similarities smo solve sonic surmised wnt
Tagcloud (Difference) ?			aberrantly antagonistic beauty becomes canonical concert connectivity ctnnb1 decipher discover facts functioning gbm gli2 hedgehog imperative integrative interplay missed ranked recapitulate relying shh similarities smo solve sonic surmised wnt
Tagcloud (Intersection) ?