SYT9 and TRPV1

Number of citations of the paper that reports this interaction (PubMedID 15066994)
0

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		SYT9	TRPV1
Description		synaptotagmin 9	transient receptor potential cation channel subfamily V member 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane Synaptic Vesicle Membrane Dense Core Granule Cytoplasmic Vesicle Synapse Exocytic Vesicle Hippocampal Mossy Fiber To CA3 Synapse	Plasma Membrane Membrane Dendritic Spine Membrane Cell Projection Neuron Projection Synapse Postsynaptic Membrane GABA-ergic Synapse
	Molecular Function	SNARE Binding Phosphatidylserine Binding Protein Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Identical Protein Binding Metal Ion Binding Calcium Ion Sensor Activity	Nucleotide Binding Transmembrane Signaling Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Excitatory Extracellular Ligand-gated Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding Calmodulin Binding ATP Binding Intracellularly Gated Calcium Channel Activity Phosphatidylinositol Binding Metal Ion Binding Phosphoprotein Binding Temperature-gated Ion Channel Activity
	Biological Process	Chemical Synaptic Transmission Vesicle-mediated Transport Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Vesicle Fusion Calcium-dependent Activation Of Synaptic Vesicle Fusion	Negative Regulation Of Transcription By RNA Polymerase II Temperature Homeostasis Fever Generation Diet Induced Thermogenesis Peptide Secretion Lipid Metabolic Process Monoatomic Ion Transport Calcium Ion Transport Cell Surface Receptor Signaling Pathway Chemosensory Behavior Response To PH Response To Heat Urinary Bladder Smooth Muscle Contraction Sensory Perception Of Pain Calcium-mediated Signaling Monoatomic Ion Transmembrane Transport Cellular Response To Heat Response To Pain Behavioral Response To Pain Sensory Perception Of Taste Sensory Perception Of Mechanical Stimulus Thermoception Detection Of Temperature Stimulus Involved In Thermoception Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Chemical Stimulus Involved In Sensory Perception Of Pain Protein Homotetramerization Transmembrane Transport Excitatory Postsynaptic Potential Smooth Muscle Contraction Involved In Micturition Calcium Ion Transmembrane Transport Cellular Response To Alkaloid Cellular Response To ATP Cellular Response To Acidic PH Calcium Ion Import Across Plasma Membrane Response To Capsazepine Calcium Ion Import Into Cytosol
Pathways		Neurexins and neuroligins Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	TRP channels
Drugs			alpha-Linolenic acid Icosapent Aspartame Tramadol Acetaminophen Camphor Ricinoleic acid Resiniferatoxin Capsaicin Cannabidiol Zucapsaicin Propacetamol Capsicum oleoresin Nonivamide (S)-camphor Medical Cannabis Nabiximols Cannabidivarin
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Breast cancer and/or colorectal cancer ( 29698419) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Chagas cardiomyopathy in Tripanosoma cruzi seropositivity ( 24324551) Dietary fat liking ( 32516399) Familial lung cancer ( 29924316) Lead levels ( 26025379) Malaria ( 31844061) Phospholipid levels (plasma) ( 22359512) QRS duration in Tripanosoma cruzi seropositivity ( 24324551)
Interacting Genes		10 interacting genes: CSNK1A1 DNAJC5 NRXN1 SNAP25 SYNCRIP TMBIM6 TMEM50A TRPV1 TUBB UPK1B	8 interacting genes: AKAP5 CALM1 EGFR ITCH PRKCE SNAPIN SYT9 TRPV2
Entrez ID		143425	7442
HPRD ID		11618	03648
Ensembl ID		ENSG00000170743	ENSG00000196689
Uniprot IDs		Q86SS6	Q8NER1
PDB IDs			6L93 8GF8 8GF9 8GFA 8JQR 8X94 8YCP
Enriched GO Terms of Interacting Partners?		Secretion Signal Release Synaptic Vesicle Exocytosis Neurotransmitter Secretion Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Temperature-gated Ion Channel Activity Response To Capsazepine Positive Regulation Of Presynaptic Active Zone Assembly Positive Regulation Of Presynapse Assembly Positive Regulation Of CAMP-mediated Signaling Protein-containing Complex Assembly Involved In Synapse Maturation Membrane Secretion By Cell Neurotransmitter Transport Regulated Exocytosis Calcium-dependent Protein Binding Vesicle-mediated Transport In Synapse Specific Granule Membrane Establishment Of Localization In Cell Calcium Channel Activity Endoribonuclease Inhibitor Activity Apical Plasma Membrane Urothelial Plaque Detection Of Chemical Stimulus Involved In Sensory Perception Of Pain Fever Generation Smooth Muscle Contraction Involved In Micturition GABA-ergic Synapse Protein Complex Involved In Cell-cell Adhesion Guanylate Kinase-associated Protein Clustering Neuromuscular Junction Positive Regulation Of Neuromuscular Synaptic Transmission Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Protein-containing Complex Assembly Synaptic Vesicle Ribbon Synapse Vesicle Monoatomic Cation Transmembrane Transport Dense Core Granule Exocytosis Metal Ion Transport Inorganic Cation Transmembrane Transport Presynaptic Membrane Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Positive Regulation Of Synaptic Transmission Vesicle Localization Learning Presynaptic Dense Core Vesicle Exocytosis Neuronal Dense Core Vesicle Exocytosis Negative Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of IRE1-mediated Unfolded Protein Response Structural Molecule Activity	Regulation Of Calcium Ion Transport Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Protein Localization To Membrane Chemical Synaptic Transmission Regulation Of Metal Ion Transport Trans-synaptic Signaling Synaptic Signaling Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Transport Regulation Of Transport Synaptic Vesicle Membrane Regulation Of Monoatomic Ion Transport Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Synaptic Transmission Regulation Of Protein Localization To Cell Periphery Modulation Of Chemical Synaptic Transmission Regulation Of Protein Localization To Membrane Positive Regulation Of Calcium Ion Import Calcineurin-mediated Signaling Regulation Of Cellular Localization Cell-cell Signaling Signaling Cell Communication Regulation Of Calcium Ion Import Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Cell Communication Regulation Of Signaling Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Cellular Component Organization Multivesicular Body, Internal Vesicle Lumen Positive Regulation Of Late Endosome To Lysosome Transport SNARE Binding Clathrin-coated Endocytic Vesicle Membrane Negative Regulation Of Cation Transmembrane Transport Positive Regulation Of Signal Transduction Intracellular Signaling Cassette Negative Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cell Communication Negative Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Cytokinesis Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Vesicle-mediated Transport In Synapse Intracellular Signal Transduction Positive Regulation Of Signaling Regulation Of Calcium-mediated Signaling Regulation Of Cell Growth Shc-EGFR Complex Synapse
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