SYT9 and NRXN1

Number of citations of the paper that reports this interaction (PubMedID 8901523)
0

Data Source:
HPRD (in vitro)

		SYT9	NRXN1
Description		synaptotagmin 9	neurexin 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane Synaptic Vesicle Membrane Dense Core Granule Cytoplasmic Vesicle Synapse Exocytic Vesicle Hippocampal Mossy Fiber To CA3 Synapse	Nucleolus Endoplasmic Reticulum Plasma Membrane Cell Surface Membrane Endocytic Vesicle Neuromuscular Junction Nuclear Membrane Vesicle Presynaptic Membrane Cell Projection Neuronal Cell Body Axonal Growth Cone Synapse Protein Complex Involved In Cell-cell Adhesion Presynapse Trans-synaptic Protein Complex Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	SNARE Binding Phosphatidylserine Binding Protein Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Identical Protein Binding Metal Ion Binding Calcium Ion Sensor Activity	Transmembrane Signaling Receptor Activity Signaling Receptor Binding Type 1 Fibroblast Growth Factor Receptor Binding Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Acetylcholine Receptor Binding Signaling Receptor Activity Metal Ion Binding Calcium-dependent Protein Binding Cell Adhesion Molecule Binding Neuroligin Family Protein Binding
	Biological Process	Chemical Synaptic Transmission Vesicle-mediated Transport Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Vesicle Fusion Calcium-dependent Activation Of Synaptic Vesicle Fusion	Angiogenesis Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Neuron Cell-cell Adhesion Signal Transduction Chemical Synaptic Transmission Neurotransmitter Secretion Axon Guidance Synapse Assembly Learning Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cerebellar Granule Cell Differentiation Neuronal Signal Transduction Adult Behavior Neuron Projection Development Positive Regulation Of Synaptic Transmission, GABAergic Social Behavior Protein Localization To Synapse Vocal Learning Positive Regulation Of CAMP-mediated Signaling Establishment Of Protein Localization Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Neuron Projection Morphogenesis Neuromuscular Process Controlling Balance Negative Regulation Of Filopodium Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Calcium Ion Vocalization Behavior Protein-containing Complex Assembly Involved In Synapse Maturation Positive Regulation Of Synapse Maturation Synaptic Vesicle Clustering Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Gamma-aminobutyric Acid Receptor Clustering NMDA Glutamate Receptor Clustering Gephyrin Clustering Involved In Postsynaptic Density Assembly Guanylate Kinase-associated Protein Clustering Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Postsynaptic Density Protein 95 Clustering Receptor Localization To Synapse NMDA Selective Glutamate Receptor Signaling Pathway AMPA Selective Glutamate Receptor Signaling Pathway Positive Regulation Of Neuromuscular Synaptic Transmission Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Presynaptic Active Zone Assembly Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Neurexins and neuroligins Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Neurexins and neuroligins Neurexins and neuroligins Non-integrin membrane-ECM interactions Neurexins and neuroligins Neurexins and neuroligins
Drugs			Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases			Pitt-Hopkins syndrome, including: Pitt-Hopkins syndrome; Pitt-Hopkins-like syndrome
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Breast cancer and/or colorectal cancer ( 29698419) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Chagas cardiomyopathy in Tripanosoma cruzi seropositivity ( 24324551) Dietary fat liking ( 32516399) Familial lung cancer ( 29924316) Lead levels ( 26025379) Malaria ( 31844061) Phospholipid levels (plasma) ( 22359512) QRS duration in Tripanosoma cruzi seropositivity ( 24324551)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Body mass index ( 28892062) Chromosomal aberration frequency (chromatid type) ( 31586183) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Colorectal cancer x fine particulate matter exposure levels interaction ( 33338681) Educational attainment ( 25201988) General risk tolerance (MTAG) ( 30643258) Isovolumetric relaxation time ( 28394258) Lateral ventricle temporal horn volume ( 31530798) Longevity ( 20834067) Lung cancer in ever smokers ( 28604730) Metabolite levels (HVA/MHPG ratio) ( 23319000) Morning person ( 30696823) Nicotine dependence symptom count ( 25555482) Personality dimensions ( 20691247) Post bronchodilator FEV1/FVC ratio ( 26634245) Recurrent major depressive disorder ( 34099189) Refractive astigmatism ( 25367360) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Severe gingival inflammation ( 28459102) Smoking initiation ( 33082346) Systolic blood pressure ( 30578418 30224653) Temperament ( 22832960) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Triglyceride levels ( 32203549) Word spelling ( 30741946)
Interacting Genes		10 interacting genes: CSNK1A1 DNAJC5 NRXN1 SNAP25 SYNCRIP TMBIM6 TMEM50A TRPV1 TUBB UPK1B	28 interacting genes: AFDN APBA1 APBA2 ATP13A2 CASK MACF1 MYO16 NLGN1 NLGN2 NLGN3 NXPH1 NXPH2 NXPH3 PDZD2 RPH3A SDCBP2 SIPA1L1 SYT1 SYT13 SYT2 SYT4 SYT5 SYT6 SYT7 SYT9 SYTL1 SYTL2 SYTL3
Entrez ID		143425	9378
HPRD ID		11618	11858
Ensembl ID		ENSG00000170743	ENSG00000179915
Uniprot IDs		Q86SS6	A0A0D9SEM5 A0A0D9SEQ7 A0A1D5RMU6 E7EQN4 H0Y568 H7BYC7 P58400 Q9ULB1
PDB IDs			3B3Q 5Z8Y 6NID
Enriched GO Terms of Interacting Partners?		Secretion Signal Release Synaptic Vesicle Exocytosis Neurotransmitter Secretion Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Temperature-gated Ion Channel Activity Response To Capsazepine Positive Regulation Of Presynaptic Active Zone Assembly Positive Regulation Of Presynapse Assembly Positive Regulation Of CAMP-mediated Signaling Protein-containing Complex Assembly Involved In Synapse Maturation Membrane Secretion By Cell Neurotransmitter Transport Regulated Exocytosis Calcium-dependent Protein Binding Vesicle-mediated Transport In Synapse Specific Granule Membrane Establishment Of Localization In Cell Calcium Channel Activity Endoribonuclease Inhibitor Activity Apical Plasma Membrane Urothelial Plaque Detection Of Chemical Stimulus Involved In Sensory Perception Of Pain Fever Generation Smooth Muscle Contraction Involved In Micturition GABA-ergic Synapse Protein Complex Involved In Cell-cell Adhesion Guanylate Kinase-associated Protein Clustering Neuromuscular Junction Positive Regulation Of Neuromuscular Synaptic Transmission Neuroligin Clustering Involved In Postsynaptic Membrane Assembly Protein-containing Complex Assembly Synaptic Vesicle Ribbon Synapse Vesicle Monoatomic Cation Transmembrane Transport Dense Core Granule Exocytosis Metal Ion Transport Inorganic Cation Transmembrane Transport Presynaptic Membrane Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Positive Regulation Of Synaptic Transmission Vesicle Localization Learning Presynaptic Dense Core Vesicle Exocytosis Neuronal Dense Core Vesicle Exocytosis Negative Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of IRE1-mediated Unfolded Protein Response Structural Molecule Activity	Exocytic Vesicle Calcium-dependent Activation Of Synaptic Vesicle Fusion Calcium-dependent Phospholipid Binding Calcium Ion Sensor Activity Positive Regulation Of Vesicle Fusion Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Calcium Ion-dependent Exocytosis Neurexin Family Protein Binding Regulation Of Regulated Secretory Pathway Regulation Of Exocytosis Modulation Of Chemical Synaptic Transmission Dense Core Granule Regulation Of Vesicle Fusion SNARE Binding Synaptic Vesicle Membrane Regulation Of Synaptic Vesicle Exocytosis Regulation Of Secretion By Cell Regulation Of Secretion Plasma Membrane Regulation Of Vesicle-mediated Transport Phosphatidylinositol-4,5-bisphosphate Binding Synapse Regulation Of Neurotransmitter Secretion Positive Regulation Of Transport Positive Regulation Of Exocytosis Secretion By Cell Vesicle-mediated Transport Positive Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Regulated Secretory Pathway Chemical Synaptic Transmission Trans-synaptic Signaling Synaptic Signaling Secretion Positive Regulation Of Cellular Component Organization Postsynaptic Membrane Assembly Excitatory Synapse Neuron To Neuron Synapse Clathrin Binding Cellular Localization Postsynaptic Membrane Organization Presynaptic Membrane Assembly Cell-cell Signaling Positive Regulation Of Secretion By Cell Presynaptic Membrane Organization Regulation Of Transport Signaling Cytoplasmic Vesicle Positive Regulation Of Secretion Cell Communication Exocytosis
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