PARP1 and TRIM29

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		PARP1	TRIM29
Gene Name		poly (ADP-ribose) polymerase 1	tripartite motif containing 29
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Envelope Nucleoplasm Transcription Factor Complex Nucleolus Membrane	Nucleoplasm Cytoplasm Intermediate Filament Cytoskeleton
	Molecular Function	DNA Binding NAD+ ADP-ribosyltransferase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Enzyme Binding Identical Protein Binding Poly(A) RNA Binding Protein N-terminus Binding NAD Binding R-SMAD Binding	P53 Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Telomere Maintenance DNA Repair Base-excision Repair Double-strand Break Repair Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Protein ADP-ribosylation Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression Protein Autoprocessing Signal Transduction Involved In Regulation Of Gene Expression Macrophage Differentiation Cellular Response To Insulin Stimulus Regulation Of Growth Rate DNA Damage Response, Detection Of DNA Damage Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of SMAD Protein Import Into Nucleus Protein Poly-ADP-ribosylation Cellular Response To Superoxide Positive Regulation Of Transcription Regulatory Region DNA Binding	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Negative Regulation Of Protein Localization To Nucleus
Pathways		Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity TGFBR1 LBD Mutants in Cancer Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Loss of Function of TGFBR1 in Cancer Generic Transcription Pathway Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer	Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system
Drugs		Carba-Nicotinamide-Adenine-Dinucleotide NU1025 Nicotinamide 2-{3-[4-(4-Fluorophenyl)-3,6-Dihydro-1(2h)-Pyridinyl]Propyl}-8-Methyl-4(3h)-Quinazolinone 3-Methoxybenzamide 2-(4-Chlorophenyl)-5-Quinoxalinecarboxamide 3,4-Dihydro-5-Methyl-Isoquinolinone 2-(3\'-Methoxyphenyl) Benzimidazole-4-Carboxamide 6-AMINO-BENZO[DE]ISOQUINOLINE-1,3-DIONE (2R)-2-(7-carbamoyl-1H-benzimidazol-2-yl)-2-methylpyrrolidinium trans-4-(7-carbamoyl-1H-benzimidazol-2-yl)-1-propylpiperidinium 5-FLUORO-1-[4-(4-PHENYL-3,6-DIHYDROPYRIDIN-1(2H)-YL)BUTYL]QUINAZOLINE-2,4(1H,3H)-DIONE
Diseases
GWAS		Melanoma ( 21983785)	Corneal curvature ( 22969067) Stroke (pediatric) ( 22990015)
Protein-Protein Interactions		84 interactors: APLF APTX ATM BCL2 BUB3 CASP1 CASP3 CASP7 CASP8 CD86 CDKN1A CENPA CENPB CREBBP CTSB CTSG E2F1 ERCC6 ERG FOXO1 GTF2F1 GZMB GZMM H2AFY HDAC1 HDAC3 HIST1H1A HIST1H1C HIST1H2BA HIST1H4A HIST1H4C HIST2H2AA3 HMGA1 HOXB7 HSPA2 KAT2B LIG3 LZTR1 MED14 MED6 MYBL2 NCL NCOA6 NEDD8 NFATC1 NFKB1 NPM1 NRF1 PARP2 PARP3 PCNA PIAS4 POLA1 POLA2 POLB POU2F1 PRKDC RARA RBM14 RELA RNF146 RPS3A RXRA SENP1 SENP3 SIRT1 SP1 SREK1 SUMO1 SUMO2 SUPT16H SWAP70 TCF4 TP53 TRIM29 UBE2I UHRF1 WRN XRCC1 XRCC5 XRCC6 ZBTB16 ZBTB9 ZNF423	40 interactors: CARD9 CEP70 CRACR2A DMRT1 FBF1 FBXL19 FXR2 GATA1 GCC1 GOLGA2 GTF2E1 HCLS1 HDAC9 HINT1 IKBKG JAKMIP2 KAT5 LZTS2 MAD1L1 MED7 MID2 MLH1 MYO15B PARP1 POLR2D POLR2E PRICKLE3 PRKCA SHOX2 SMAD9 SNAPC1 SP100 TAX1BP3 TRIM11 TRIM23 TRIM27 TRIP6 TSGA10 UBE2I VIM
Entrez ID		142	23650
HPRD ID		01435	10280
Ensembl ID		ENSG00000143799	ENSG00000137699
Uniprot IDs		P09874	B7Z8U9 E9PRL4 Q14134
PDB IDs		1UK0 1UK1 1WOK 2COK 2CR9 2CS2 2DMJ 2JVN 2L30 2L31 2RCW 2RD6 2RIQ 3GJW 3GN7 3L3L 3L3M 3OD8 3ODA 3ODC 3ODE 4AV1 4DQY 4GV7 4HHY 4HHZ 4L6S	2CSV
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Cellular Response To DNA Damage Stimulus Positive Regulation Of Transcription, DNA-templated DNA Metabolic Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Chromosome Organization Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process DNA Repair Cellular Response To Stress Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Response To Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Metabolic Process Transcription, DNA-templated Telomere Maintenance Negative Regulation Of Transcription, DNA-templated Viral Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Metabolic Process Negative Regulation Of Gene Expression Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Biosynthetic Process Gene Expression Apoptotic Signaling Pathway Base-excision Repair Regulation Of Apoptotic Process Biosynthetic Process Cellular Response To Stimulus Organelle Organization Response To Stimulus	Regulation Of Viral Transcription Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Viral Transcription Negative Regulation Of Cellular Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Viral Process Regulation Of Viral Process Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Gene Expression Negative Regulation Of Viral Release From Host Cell Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression RNA Metabolic Process Immune System Process Intracellular Signal Transduction Positive Regulation Of Cellular Biosynthetic Process Regulation Of Viral Release From Host Cell Negative Regulation Of Viral Process Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cell Differentiation Regulation Of Cellular Localization Regulation Of Protein Localization DNA-templated Transcription, Initiation Innate Immune Response Organelle Organization Regulation Of Signal Transduction Cellular Macromolecule Biosynthetic Process Spindle Midzone Assembly Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Positive Regulation Of Signal Transduction Transcription Elongation From RNA Polymerase II Promoter Response To Stress Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Tagcloud ?		ageing ascribes atm attrition brca1 complexity ctip ends fusions homologous instability insufficient joining ku70 lig3 lig4 mechanistically nhej overhang rampant relies repeats telomere telomeres telomeric trf2 unanticipated uncapped underlining	adenocarcinoma ataxia atdc atm basis candidacy damaging directly ductal improve ionizing leading mapkap mk2 pancreatic pdac phosphorylated poorly radiation radioprotective radioresistance radiosensitize repair ser ser550 telangiectasia therapeutic understood xenograft
Tagcloud (Difference) ?		ageing ascribes attrition brca1 complexity ctip ends fusions homologous instability insufficient joining ku70 lig3 lig4 mechanistically nhej overhang rampant relies repeats telomere telomeres telomeric trf2 unanticipated uncapped underlining	adenocarcinoma ataxia atdc basis candidacy damaging directly ductal improve ionizing leading mapkap mk2 pancreatic pdac phosphorylated poorly radiation radioprotective radioresistance radiosensitize repair ser ser550 telangiectasia therapeutic understood xenograft
Tagcloud (Intersection) ?		atm