CRYGA and HSPA13

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CRYGA	HSPA13
Description		crystallin gamma A	heat shock protein family A (Hsp70) member 13
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Structural Constituent Of Eye Lens	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity Heat Shock Protein Binding Protein Folding Chaperone ATP-dependent Protein Folding Chaperone
	Biological Process	Eye Development Lens Development In Camera-type Eye Visual Perception	Protein Folding Protein Refolding
Pathways			Regulation of HSF1-mediated heat shock response
Drugs			Copper
Diseases
GWAS
Interacting Genes		5 interacting genes: AGR2 DPH2 HSPA13 PSMB9 TRAF1	43 interacting genes: AHCY APP ARHGAP5 BAG6 CAMLG CAND1 CHMP3 CKAP5 CLU CRYGA CTNNA1 DHX30 DHX35 DNM1 DNM3 FRY GIT1 HSP90B1 HSPH1 KIAA0319L LRBA MVP OGT PCBP1 PLXNB3 POLE4 PPP4R3B PSAP PTGES2 PTK2 RALBP1 RMI1 SGTA SGTB SSR1 ST18 TLN2 UBQLN1 UBQLN2 UBQLN4 UBR4 WDR3 XPOT
Entrez ID		1418	6782
HPRD ID		00433	03061
Ensembl ID		ENSG00000168582	ENSG00000155304
Uniprot IDs		A0A0S2A4T3 P11844	A0A140VK72 P48723
PDB IDs
Enriched GO Terms of Interacting Partners?		2-(3-amino-3-carboxypropyl)histidine Synthase Complex Protein Histidyl Modification To Diphthamide 2-(3-amino-3-carboxypropyl)histidine Synthase Activity Threonine-type Endopeptidase Activity Spermatoproteasome Complex Proteasome Core Complex, Beta-subunit Complex Thioesterase Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Muscle Atrophy Ripoptosome Positive Regulation Of Cell Proliferation Involved In Kidney Development Negative Regulation Of Hepatocyte Apoptotic Process Skeletal Myofibril Assembly Negative Regulation Of Myoblast Fusion Negative Regulation Of Syncytium Formation By Plasma Membrane Fusion Death-inducing Signaling Complex Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Skeletal Muscle Atrophy CD95 Death-inducing Signaling Complex Skeletal Muscle Adaptation Regulation Of Glomerular Mesangial Cell Proliferation Striated Muscle Atrophy Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Glomerular Mesangial Cell Proliferation Lung Goblet Cell Differentiation Dystroglycan Binding Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Skeletal Muscle Cell Proliferation Cellular Response To Nitric Oxide Death Receptor Binding Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Hepatocyte Proliferation Regulation Of Skeletal Muscle Satellite Cell Proliferation Cellular Response To Reactive Nitrogen Species Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of IRE1-mediated Unfolded Protein Response Regulation Of PERK-mediated Unfolded Protein Response Mucus Secretion	Positive Regulation Of Proteolysis Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of ERAD Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of ERAD Pathway Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Cellular Component Assembly Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Polyubiquitin Modification-dependent Protein Binding ERAD Pathway TRC Complex Positive Regulation Of Catabolic Process Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of Proteasomal Protein Catabolic Process Protein Targeting Positive Regulation Of Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Membrane Low-density Lipoprotein Particle Receptor Binding Chromaffin Granule Localization Within Membrane Perinuclear Region Of Cytoplasm Regulation Of Cellular Response To Stress Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Regulation Of Protein Metabolic Process Cellular Localization Protein Insertion Into ER Membrane Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Protein Targeting To ER Identical Protein Binding Cytosol Establishment Of Protein Localization To Endoplasmic Reticulum Protein Phosphatase Binding Autophagy Cytoplasm Positive Regulation Of Protein Metabolic Process Establishment Of Protein Localization To Membrane Positive Regulation Of Microtubule Nucleation Cytoskeleton Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Manganese Ion Establishment Of Protein Localization Negative Regulation Of Protein Catabolic Process
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