CRYGA and DPH2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CRYGA	DPH2
Description		crystallin gamma A	diphthamide biosynthesis 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Cytosol Protein-containing Complex 2-(3-amino-3-carboxypropyl)histidine Synthase Complex
	Molecular Function	Structural Constituent Of Eye Lens	Protein Binding Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding 2-(3-amino-3-carboxypropyl)histidine Synthase Activity
	Biological Process	Eye Development Lens Development In Camera-type Eye Visual Perception	Protein Histidyl Modification To Diphthamide
Pathways			Synthesis of diphthamide-EEF2
Drugs
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026)
Interacting Genes		5 interacting genes: AGR2 DPH2 HSPA13 PSMB9 TRAF1	7 interacting genes: CRYGA FARS2 IL17A MAGOH MISP NEK6 TNK2
Entrez ID		1418	1802
HPRD ID		00433	16023
Ensembl ID		ENSG00000168582	ENSG00000132768
Uniprot IDs		A0A0S2A4T3 P11844	B3KRB8 Q9BQC3
PDB IDs
Enriched GO Terms of Interacting Partners?		2-(3-amino-3-carboxypropyl)histidine Synthase Complex Protein Histidyl Modification To Diphthamide 2-(3-amino-3-carboxypropyl)histidine Synthase Activity Threonine-type Endopeptidase Activity Spermatoproteasome Complex Proteasome Core Complex, Beta-subunit Complex Thioesterase Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Muscle Atrophy Ripoptosome Positive Regulation Of Cell Proliferation Involved In Kidney Development Negative Regulation Of Hepatocyte Apoptotic Process Skeletal Myofibril Assembly Negative Regulation Of Myoblast Fusion Negative Regulation Of Syncytium Formation By Plasma Membrane Fusion Death-inducing Signaling Complex Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Skeletal Muscle Atrophy CD95 Death-inducing Signaling Complex Skeletal Muscle Adaptation Regulation Of Glomerular Mesangial Cell Proliferation Striated Muscle Atrophy Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Glomerular Mesangial Cell Proliferation Lung Goblet Cell Differentiation Dystroglycan Binding Positive Regulation Of IRE1-mediated Unfolded Protein Response Positive Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Skeletal Muscle Cell Proliferation Cellular Response To Nitric Oxide Death Receptor Binding Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Hepatocyte Proliferation Regulation Of Skeletal Muscle Satellite Cell Proliferation Cellular Response To Reactive Nitrogen Species Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of IRE1-mediated Unfolded Protein Response Regulation Of PERK-mediated Unfolded Protein Response Mucus Secretion
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