SMCP and IGFBP6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SMCP	IGFBP6
Description		sperm mitochondria associated cysteine rich protein	insulin like growth factor binding protein 6
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Membrane Mitochondrial Membrane	Extracellular Region Extracellular Space Insulin-like Growth Factor Binary Complex
	Molecular Function	Protein Binding	Fibronectin Binding Signaling Receptor Binding Protein Binding Insulin-like Growth Factor Binding Growth Factor Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Identical Protein Binding
	Biological Process	Single Fertilization Penetration Of Zona Pellucida Flagellated Sperm Motility	Signal Transduction Negative Regulation Of Cell Population Proliferation Cell Migration Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of MAPK Cascade Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways			Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs
Diseases
GWAS		Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)	Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644)
Interacting Genes		78 interacting genes: ALPP C14orf119 CALCOCO2 CGB3 CGB5 CGB8 CTAG2 CYSRT1 DYNLL1 DYNLL2 GOLGA2 GRN GUCD1 HOXA1 IGFBP6 KRT31 KRT34 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-3 KRTAP12-4 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP4-7 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE1A LCE1B LCE1D LCE1E LCE1F LCE2C LCE2D LCE3A LCE3B LCE4A LCE5A MACO1 MT1B MT1M NBPF19 NOTCH2NLA PCSK5 PLEKHG4 PLSCR1 PLSCR3 PPP1R27 PRDX5 RGS17 SLC39A7 SPRY1 TCF4 TRIM42 UBL5 VASN	38 interacting genes: ALPP ANKRD11 AQP1 C1orf74 CCDC116 CCDC28A CDIPT CREB5 DRC4 EFEMP1 EFEMP2 ENKD1 EPDR1 GET3 IGF1 IGF2 KRTAP10-8 KRTAP5-7 KRTAP5-9 MBD3 MEIS2 MSGN1 MYCBP2 NCALD PLEKHA7 POU4F2 RABGGTB RANBP10 SDCBP SGTA SMCP TF UBAC1 UBQLN1 UBQLN2 UBQLN4 ZNF417 ZNF587
Entrez ID		4184	3489
HPRD ID		03093	00902
Ensembl ID		ENSG00000163206	ENSG00000167779
Uniprot IDs		P49901 Q5T7P5	F8VVA5 P24592
PDB IDs			1RMJ 2JM2
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Epidermis Development Keratinization Hair Cycle Tissue Development Identical Protein Binding Cytosol Lead Ion Binding Mercury Ion Binding Intracellular Zinc Ion Homeostasis	Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Exocrine Pancreas Development Positive Regulation Of Transcription Regulatory Region DNA Binding Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Axon Guidance
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