SMCP and CGB8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SMCP	CGB8
Description		sperm mitochondria associated cysteine rich protein	chorionic gonadotropin subunit beta 8
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Membrane Mitochondrial Membrane
	Molecular Function	Protein Binding
	Biological Process	Single Fertilization Penetration Of Zona Pellucida Flagellated Sperm Motility
Pathways			Glycoprotein hormones TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
Drugs
Diseases
GWAS		Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)	Iron status biomarkers (ferritin levels) ( 33536631)
Interacting Genes		78 interacting genes: ALPP C14orf119 CALCOCO2 CGB3 CGB5 CGB8 CTAG2 CYSRT1 DYNLL1 DYNLL2 GOLGA2 GRN GUCD1 HOXA1 IGFBP6 KRT31 KRT34 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-3 KRTAP12-4 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP4-7 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE1A LCE1B LCE1D LCE1E LCE1F LCE2C LCE2D LCE3A LCE3B LCE4A LCE5A MACO1 MT1B MT1M NBPF19 NOTCH2NLA PCSK5 PLEKHG4 PLSCR1 PLSCR3 PPP1R27 PRDX5 RGS17 SLC39A7 SPRY1 TCF4 TRIM42 UBL5 VASN	2 interacting genes: CFTR SMCP
Entrez ID		4184	94115
HPRD ID		03093	12311
Ensembl ID		ENSG00000163206	ENSG00000213030
Uniprot IDs		P49901 Q5T7P5	P0DN86
PDB IDs			1HCN 1HRP 1QFW 7FIG 7FIH 7FII
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Epidermis Development Keratinization Hair Cycle Tissue Development Identical Protein Binding Cytosol Lead Ion Binding Mercury Ion Binding Intracellular Zinc Ion Homeostasis	Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Cilium Movement Outer Dynein Arm Docking Complex Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Microtubule-based Movement Penetration Of Zona Pellucida Outer Dynein Arm Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Golgi-associated Vesicle Membrane Cellular Response To Forskolin Response To Forskolin Chloride Transmembrane Transporter Activity Sperm Capacitation Outer Dynein Arm Assembly Bicarbonate Transport Water Transport Multicellular Organismal-level Water Homeostasis Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Ion Transmembrane Transporter Activity Cholesterol Biosynthetic Process 14-3-3 Protein Binding Fluid Transport Transepithelial Transport Microtubule-based Process Axonemal Dynein Complex Assembly Vesicle Docking Involved In Exocytosis Positive Regulation Of Transporter Activity ABC-type Transporter Activity Sterol Biosynthetic Process Chloride Channel Complex Positive Regulation Of Biomineral Tissue Development Cellular Response To CAMP Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Vesicle Docking Cholesterol Transport
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