MICAL1 and NEDD9

Number of citations of the paper that reports this interaction (PubMedID 11827972)
0

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)
HPRD (in vivo, in vitro)

		MICAL1	NEDD9
Description		microtubule associated monooxygenase, calponin and LIM domain containing 1	neural precursor cell expressed, developmentally down-regulated 9
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endosome Cytosol Cytoskeleton Intermediate Filament Actin Filament Plasma Membrane Cilium Endosome Membrane Actin Cytoskeleton Membrane Midbody Ciliary Basal Body Intercellular Bridge Plasma Membrane Bounded Cell Projection Hippocampal Mossy Fiber Expansion	Spindle Pole Immunological Synapse Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Spindle Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cilium Cell Cortex Membrane Basolateral Plasma Membrane Lamellipodium Ciliary Basal Body Cell Projection Anchoring Junction Mitotic Spindle
	Molecular Function	Actin Binding Monooxygenase Activity Protein Binding NAD(P)H Oxidase H2O2-forming Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen SH3 Domain Binding Protein Kinase Binding Small GTPase Binding Metal Ion Binding Actin Filament Binding FAD Binding F-actin Monooxygenase Activity	Protein Binding Protein Tyrosine Kinase Binding
	Biological Process	Cytoskeleton Organization Signal Transduction Sulfur Oxidation Actin Filament Depolymerization Negative Regulation Of Apoptotic Process Actin Filament Bundle Assembly Regulation Of Regulated Secretory Pathway	Cytoskeleton Organization Cell Adhesion Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Learning Or Memory Cell Migration Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Osteoclast Differentiation Actin Filament Bundle Assembly Cell Division Positive Regulation Of Protein Tyrosine Kinase Activity Cilium Disassembly Lymphocyte Migration Into Lymphoid Organs Positive Regulation Of Lymphocyte Chemotaxis Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Dendritic Spine Maintenance Positive Regulation Of Protein Localization Positive Regulation Of Immunological Synapse Formation
Pathways		Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Depression in smokers ( 30219690) Height ( 28552196)	Childhood dental caries in permanent teeth ( 29931343) Coronary artery disease ( 29212778) Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) HIV-1 susceptibility ( 22174851) Macular thickness ( 30535121) Prostate cancer ( 25217961) Small cell lung carcinoma ( 28604730)
Interacting Genes		16 interacting genes: ABL1 CRK EHD1 GADD45A GRB2 GSK3B NEDD9 PIK3R3 PTK2 RAB10 RAB1A RAB1B RPS6KA6 SRC TAB1 VIM	70 interacting genes: ABL1 ACTMAP ANKS1A APP AURKA BANP BCAR1 BCAR3 CDC42EP2 CDH1 CHAT CRK CRKL DIMT1 DMRTB1 DOCK9 DPPA4 EEIG1 ELSPBP1 EXOSC8 FAM168B FOSB FYN FZR1 HOXA1 ID2 INCA1 ITCH KLHL20 KRT32 LCK LHX8 LYN MED19 MICAL1 NAB2 NBPF19 NCK1 NFKBIA NOTCH2NLA NOTCH3 PEX14 PIK3CA PIK3R3 PRAM1 PRR20A PTK2 PTK2B PTPN11 PTPN12 PXN RAPGEF1 RBPMS REL RFX6 SH2D3C SMAD1 SMAD2 SMAD3 SNAPIN TBX19 TCF3 TFCP2 TRAF2 TRIM23 TRIM27 TRIP6 WWOX ZNF76 ZYX
Entrez ID		64780	4739
HPRD ID		06183	11888
Ensembl ID		ENSG00000135596	ENSG00000111859
Uniprot IDs		Q8TDZ2	A0A087WUD2 Q14511
PDB IDs		1WYL 2CO8 2DK9 5LE0 5LPN 6KU0 8HLO 8Y6K 9EWY	2L81 5X3S
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Ephrin Receptor Binding Cell Projection Organization Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell-substrate Adhesion SH2 Domain Binding Phosphotyrosine Residue Binding Ephrin Receptor Signaling Pathway Organelle Organization Regulation Of Substrate Adhesion-dependent Cell Spreading Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of Cell Migration Scaffold Protein Binding Positive Regulation Of Cell Motility Negative Regulation Of Anoikis ERBB Signaling Pathway Positive Regulation Of Locomotion Nucleotide Binding Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Migration Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of MAPK Cascade Establishment Of Cell Polarity Regulation Of Cell Projection Organization Protein Domain Specific Binding Regulation Of Anoikis Integrin-mediated Signaling Pathway Regulation Of Cell Motility Cell Motility Regulation Of Locomotion Cellular Response To Fluid Shear Stress Fc-gamma Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Regulation Of Cell-matrix Adhesion Cytoplasm Positive Regulation Of Cell-substrate Adhesion Regulation Of Organelle Organization Epithelial Cell Development Regulation Of Cytoskeleton Organization Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Metabolic Process Developmental Process Response To Fluid Shear Stress Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Mononuclear Cell Migration	Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Phosphotyrosine Residue Binding Ephrin Receptor Binding Ephrin Receptor Signaling Pathway Cytosol Cell Surface Receptor Signaling Pathway Response To Growth Factor Antigen Receptor-mediated Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Macromolecule Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Leukocyte Activation Cell Activation Positive Regulation Of Metabolic Process T Cell Receptor Signaling Pathway Cell Migration Response To Transforming Growth Factor Beta Signal Complex Assembly Positive Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Immune Response-activating Signaling Pathway Positive Regulation Of RNA Biosynthetic Process ERBB Signaling Pathway Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of Immune Response Lymphocyte Activation Intracellular Signaling Cassette Immune System Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Intracellular Signal Transduction Endothelin Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Integrin-mediated Signaling Pathway DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process Cell Motility Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cytoplasm Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Nucleus Signal Transduction Regulation Of Metabolic Process
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